Czech and Slovak Pharmacy, 2019 (vol. 68), issue 2
Original Articles
Influence of formulation and process parameters on the properties of Cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis
Miroslava Pavelková, Jakub Vysloužil, Kateřina Kubová, Sylvie Pavloková, Eliška Mašková, David Vetchý
Čes. slov. farm. 2019, 68(2):69-77 | DOI: 10.36290/csf.2019.009 
Currently, the method of external ionic gelation for the preparation of alginate particles is successfully used not only in the field of pharmacy and medicine, but also especially in the field of biotechnology. Therefore, the preparation of alginate particles and their subsequent evaluation using principal component analysis was the key task of our experiment. To optimize this method, we focused on the evaluation of the effect of formulation (the polymer concentration, the hardening solution concentration) and process parameters (the outer diameter of the injection needle) on the properties of the resulting beads (yield, sphericity factor, equivalent...
OTC market - comparing Czech Republic and Greece
Božena Macešková, Marios-Panagiotis Tsadaris, Michail Machlis
Čes. slov. farm. 2019, 68(2):78-85 | DOI: 10.36290/csf.2019.010
Medicines for self-medication (over-the-counter, OTC) are available through pharmacies, in some countries they are also available in supermarkets and other outlets. The use of OTC in European Union countries shows some differences at national level, in pharmacies and in patients' preference. This study aimed to completing the lists of marketed OTC in Czech Republic and Greece. Next topics are: finding out the real range of OTC products offered by pharmacies, finding and evaluating number of packages sold in pharmacies in 20 particular common OTC in 2016, and indentification of factors influencing the sales. Web pages of national drug authorities (Czech...
Review articles
Bevacizumab treatment in metastatic colorectal carcinoma - an economic perspective
Irena Sehnalová, Barbora Říhová, Regina Demlová
Čes. slov. farm. 2019, 68(2):43-47 | DOI: 10.36290/csf.2019.007
Targeted therapy is a significant benefit in the treatment of cancer patients. Bevacizumab improves overall survival (OS) and progression free survival (PFS) in the treatment of metastatic colorectal cancer (mCRC). The clinical effectiveness of bevacizumab is similar to its efficacy in randomised controlled trials. However, the costs of bevacizumab treatment as well as other agents of targeted treatment are discussed between the health care payers, the regulatory authorities and the members of professional societies. Biomarkers of bevacizumab treatment helpful in the selection of eligible groups of patients are still missing. This review focuses on...
Prenylated phenols with cytotoxic and antiproliferative activity isolated from Morus alba
Nikol Prausová, Peter Kollár
Čes. slov. farm. 2019, 68(2):48-68 | DOI: 10.36290/csf.2019.008
This review deals with cytotoxic and antiproliferative activity of fifty seven prenylated phenols isolated from Morus alba. Prenyl side chain, which can be variously modified, increases lipophilicity of the substances, thereby improving their penetration through biological membranes and thus results in an increased bioavailability. The objective was to describe the relationship between structure of the prenylated phenols and their cytotoxic effect and to clarify various mechanisms by which cytotoxic prenylated phenols induce apoptosis. The conclusions showed that the cytotoxicity of the substances increases with increasing number of the prenyl...