Preparation and evalution of the oral gel containing the essential oil from Siberian fir (Abies sibirica Ledeb.)

Rizvangul Ajupova, Ruta Masteiková, Marcela Nejezchlebová, Milan Žemlička, Jurga Bernatonienė, David Vetchý

Čes. slov. farm. 2014, 63(3):113-119 | DOI: 10.36290/csf.2014.021  

Essential oil of the Siberian fir (Abies sibirica Ledeb.) ranks among the substances with potential use in prevention and treatment of oral candidiasis. Therefore, the aim of the study was the formulation, preparation and evaluation of an oral gel containing 0.3% of this essential oil. Carbopol 974P NF in 1% concentration was used as the gelling agent, some samples were additionally stabilized by an addition of polysorbate 80 (0.1-0.5%). Xylitol in concentrations of 10% or 20% was added with the aim to modify the taste properties of the gel. Following microscopic evaluation (mean oil droplet size, degree of dispersity) immediately after preparation...

Flavonoids - main constituents of the leaves of Philadelphus tenuifolius Rupr. et Maxim.

Daniel Grančai, Silvia Fialová, Viktor Huszár, Janka Karlovská, Emil Švajdlenka

Čes. slov. farm. 2014, 63(3):120-122 | DOI: 10.36290/csf.2014.023  

The paper deals with the isolation and identification of the constituents of the leaves of Philadelphus tenuifolius Rupr. et Maxim. A methanolic extract was used to isolate quercetin-3-O-glucoside (isoquercitrin), and a butanolic extract to isolate kaempferol-3-O-glucoside-7-O-rhamnoside. Isolates were identified by physical-chemical data, comparison with authentic samples and literature data. The above-mentioned compounds were isolated from Philadelphus tenuifolius Rupr. et Maxim. for the first time.

Formulation of benzethonium chloride into gels

Jozef Čižmárik, Zuzana Vitková, Petra Herdová, Alexandra Kodadová, Daniel Vími

Čes. slov. farm. 2014, 63(3):123-126 | DOI: 10.36290/csf.2014.024  

This study is focused on the preparation of gels with antimicrobial effects. A quaternary ammonium salt, benzethonium chloride, in a concentration of 0.01-0.5% (w/w) was employed as the drug. The humectant employed was propylene glycol in concentrations of 5% and 10% (w/w). Two types of polymers, chitosan and hydroxyethyl cellulose, in the same concentrations of 2.5% (w/w), were used for gel preparation. Finally the flow properties, rheological parameters and pH values of the gels were evaluated. Based on the obtained results, the samples of the gels prepared on the basis of chitosan and hydroxyethyl cellulose, which have the following optimum composition...

Impact of formulation and process parameters on the properties of chitosan-based microspheres prepared by external ionic gelation

Romana Kubánková, Jakub Vysloužil, Martina Kejdušová, David Vetchý, Kateřina Dvořáčková

Čes. slov. farm. 2014, 63(3):127-135 | DOI: 10.36290/csf.2014.026  

The aim of this experimental study was to optimize a preparation of microspheres from high viscosity chitosan by external ion gelation and to evaluate selected aspects of their preparation. For drug-free microparticles, the concentration of chitosan dispersions was chosen as a formulation variable; the position of instrument for a dispersion extrusion (horizontal vs. vertical) was evaluated as a process variable. On the basis of sphericity and equivalent diameter results, three different concentrations of chitosan dispersions were used for 5-aminosalicylic acid (5-ASA) encapsulation with the extrusion instrument in horizontal position, which was considered...

Advances in the use of instrumental measurement of colour in the development, production and quality control of drugs, medicinal preparations and pharmaceutical auxiliary substances II

Jan Šubert, Jozef Čižmárik

Čes. slov. farm. 2014, 63(3):107-112 | DOI: 10.36290/csf.2014.020  

The paper summarizes the use of instrumental colour measurement in the field of pharmaceuticals of natural origin and other substances of natural origin beneficial for health in recent 10 years. Colour measurement in this field was most frequently employed in the monitoring of various aspects of the process of drying of medicinal plants and their parts.

Alois Jandouš's Czech pharmacopoeial terminology of 1864

Pavel Drábek

Čes. slov. farm. 2014, 63(3):136-140 | DOI: 10.36290/csf.2014.028  

PhMr. Alois Jandouš (1838-1893), a Prague pharmacist, laid the foundations of modern Czech pharmaceutical literature. His first Czech book was a Latin-Czech dictionary published in 1864. Jandouš collected the terms from the 5^th edition of the Austrian Pharmacopoeia. Besides Czech translations of nine hundred Latin names of pharmaceuticals, it also presented many Czech synonyms and translations of other technical terms. Though not all of his proposed terms have been accepted, he has established modern Czech pharmaceutical terminology.

Rationalization in 20th-century Czechoslovak pharmacy practice - Commission for Rationalization and Standardization in Medicine, Veterinary Medicine and Pharmacy - Part 1

Jan Babica, Václav Rusek

Čes. slov. farm. 2014, 63(3):141-146 | DOI: 10.36290/csf.2014.029  

In the 1920s Czechoslovakia, an increased attention was paid to the new ideas of scientific management (Taylorism), work rationalization and standardization. This was reflected in the foundation of the Masaryk Academy of Work in 1920. An effort to implement the new principles into health care led to the establishment of the Commission for Rationalization and Standardization in Medicine, Veterinary Medicine and Pharmacy (RANOK) within the Department of Natural Science and Medicine of the Academy. Within RANOK, the group for pharmacy worked between 1928-1932. The first part of the paper describes the scientific management and standardization movement...

Lekárne a lekárnici v okrese Žilina pred rokom 1990

J. Čižmárik

Čes. slov. farm. 2014, 63(3):135  

Hradec Králové hostil mladé farmaceutické chemiky z celé Evropy

Martin Doležal

Čes. slov. farm. 2014, 63(3):119  

9^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - PBP Meeting

K. Dvořáčková

Čes. slov. farm. 2014, 63(3):126