Possibilities of influencing the drug content and encapsulation efficiency of chitosan microspheres prepared by ionic gelation process

Jan Kouřil, Jakub Vysloužil, Martina Kejdušová, Kateřina Dvořáčková, David Vetchý

Čes. slov. farm. 2014, 63(2):75-83 | DOI: 10.36290/csf.2014.015  

This study aimed to prepare high molecular weight chitosan blank and drug-loaded microparticles using 5-aminosalicylic acid (5-ASA) as the model active substance by an external ionic gelation. Formulation and process variables included the chitosan concentration and presence of drug in the polymer solution, and/or in hardening solution during the microparticles preparation. The effect of different preparation conditions on the properties of the microparticles was observed with a view to increase drug content in microparticles. For both types of microparticles (with and without the drug), it was found that their sphericity and equivalent diameter increased...

Medical and entrepreneurial character of the community pharmacy

Ivona Malovecká, Igor Minarovič, Daniela Mináriková, Miroslava Snopková, Ľubica Lehocká, Viliam Foltán

Čes. slov. farm. 2014, 63(2):84-89 | DOI: 10.36290/csf.2014.016  

Community pharmacy provides citizens with pharmaceutical care and runs its health care business on the market with state regulatory interventions. These restrictions affect its stability and because of that it has to be constantly monitored. The convenient way of monitoring the financial health of a community pharmacy is the use of financial analysis and its outcomes that are profitability, liquidity, debt and productivity ratios. The aim of this paper was to determine the economic situation in the public pharmacy services in Slovakia. A representative set of community pharmacies was established that reflected the criteria of localization by regions...

Selected natural phenolic compounds - potential treatment for peripheral neuropathy?

Karel Šmejkal

Čes. slov. farm. 2014, 63(2):55-70 | DOI: 10.36290/csf.2014.012  

Neuropathic pain is a syndrome comprising pain caused by a lesion or dysfunction of the nervous system, or resulting from lesions or diseases of the somatosensory system. Neuropathic pain is often connected with adverse effects of chemotherapy administered because of cancer, infiltration of the nervous tissue with cancer cells, neurodegeneration and diabetes mellitus. Disbalance in the production of various cytokines plays an important role in the pathogenesis of many of the diseases connected with neuropathies. These cytokines comprise in particular interleukins IL-1β, IL-15, and IL-6, tumour necrosis factors, and prostaglandins. The biochemistry...

Active pharmaceutical ingredients available as substances for extemporaneous preparation in veterinary medicine in the Czech Republic

Zbyněk Sklenář, Kateřina Horáčková, Hana Bakhouche

Čes. slov. farm. 2014, 63(2):71-74 | DOI: 10.36290/csf.2014.013  

In veterinary medicine, extemporaneously prepared drugs can be also used in therapy. In the recent four years the selection of suitable compounds for extemporaneous (magistral) preparation has been expanded and new possibilities for the creation of formulas have appeared. The paper reports on the substances available for compounding that can be used in veterinary medicine, in the pharmacotherapeutic classes antibiotics, antimycotics, antiseptics, corticosteroids, emollients and epithelizing agents, anti-inflammatory drugs, local anesthetics, decongestives, beta-blockers and calcium channel blockers, antiemetics and prokinetics, sedatives and hypnotics....

History of the development and production of drugs in the firm Lachema in Brno

Aleš Franc

Čes. slov. farm. 2014, 63(2):90-98 | DOI: 10.36290/csf.2014.017  

Since the 1980 year Lachema Brno was ranked among the leading pharmaceutical companies in Czechoslovakia. Lachema was founded already in 1951 but the modern factory was built around the Research Institute in the 1970s. Although Lachema existed separately, it became the property of Chemapol after privatization. After bankruptcy of Chemapol, Lachema was purchased by the largest Eastern European generic company Pliva. In 2006 Pliva became part of the U.S. generic pharmaceutical company Barr Pharmaceuticals. Finally, in 2008, Barr was acquired by Teva and Lachema was subsequently shut down. Although in the Czech Republic Lachema was almost the monopoly...

Pracovní den sekce technologie léků České farmaceutické společnosti ČLS JEP. Pokroky v lékových formách

Čes. slov. farm. 2014, 63(2):99-103  

41. mezinárodní kongres pro dějiny farmacie v Paříži

T. Ambrus

Čes. slov. farm. 2014, 63(2):74  

Doc. Mgr. Fils Andriamainty, PhD., ocenený SFS

J. Čižmárik

Čes. slov. farm. 2014, 63(2):104