Cationic Eudragit^® Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Jakub Vysloužil, Jana Bavoľárová, Martina Kejdušová, David Vetchý, Kateřina Dvořáčková

Čes. slov. farm. 2013, 62(6):249-254  

Three cationic acrylic polymers, i. e. Eudragit^® RL, Eudragit^® RS and Eudragit^® E 100, were evaluated for the purpose of microparticles preparation by the solvent evaporation method. The practically insoluble drug mirtazapine and the freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. The prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit^® RL did not provide microparticles while Eudragit^® RS and Eudragit^® E 100 yielded...

Influence of quaternary ammonium salt on liberation of drug with antiseptic effect

Zuzana Vitková, Petra Herdová, Jarmila Oremusová, Jozef Čižmárik, Katarína Tóthová

Čes. slov. farm. 2013, 62(6):255-258  

The paper evaluates the influence of three surfactants (carbetopendecinium halogenides) on the liberation of the drug chlorhexidine dihydrochloride (CHX) in 0.1% (w/w) from the dosage form-gel and also the flow properties of gels. The following tensides were evaluated: carbetopendecinium bromide (SB), carbetopendecinium chloride (SC), and carbetopendecinium iodide (SI). The tenside concentration was set under the critical micelle concentration. The biopolymer - chitosan (CHIT) in 2.5% (w/w) concentration was used as a gel creating substance. Based on the flow properties of the studied gels, it was found that the employed tensides exhibited no influence...

Monitoring of formation of diclofenac sodium salt hydrates and their influence on the drug dissolution from prepared tablets

Petr Doležel, Jan Muselík, Michaela Králová, David Vetchý

Čes. slov. farm. 2013, 62(6):259-263  

NIR spectroscopy together with multivariate data analysis were used to analyze the hydrates of diclofenac sodium prepared from the non-aqueous solvents tetrahydrofuran and methanol under standard laboratory conditions at 20 °C and relative humidity less than 60%. It was confirmed that the developed PLS regression model can monitor the process of formation of hydrates. It was also found that the hydrated form of diclofenac sodium arises during the preparation of the dosage form the using technology of impregnating the solid carrier by non-aqueous solvents, which resulted in reducing of the drug release rate from prepared tablets up to twice. NIR spectroscopy...

Alkalimetric titrations of salts of organic bases in the Pharmacopoeia

Želmíra Bezáková, Mária Stankovičová

Čes. slov. farm. 2013, 62(6):264-269  

Modified methods - alkalimetry in ethanol 70% with a defined small volume of hydrochloric acid 0.01 mol/l added to the solution of the sample before the titration and alkalimetry in ethanol 70% or ethanol 96% alone with potentiometric end-point detection for the assay of halide salts of 11 organic N-bases has been investigated. The results were compared to those obtained by the method of the European Pharmacopoeia 7th Ed. (Ph. Eur. 7th Ed.). The Ph. Eur. 7th Ed. use for 8 investigated substances alkalimetry in alcohol 96 % with a defined small volume of hydrochloric acid 0.01 mol/l (5 ml) with potentiometric end-point detection: Cinchocaine hydrochloride,...

Determination of varenicline in the preparation Champix^® with the use of two-dimensional capillary electrophoresis in connection with UV detection

Juraj Piešťanský, Katarína Maráková, Lucia Veizerová, Jaroslav Galba, Peter Mikuš

Čes. slov. farm. 2013, 62(6):270-275  

This paper deals with an analytical method based on two dimensional capillary electrophoresis (CITP-CZE coupling) with simple UV-detection for the determination of a highly effective drug - varenicline. The method was elaborated with the possibility of its future connection with an advanced detection ending - mass spectrometry. The electrolytes for the CITP (LE = 10 mM NH₄Ac + 5 mM HAc + 0,05% m-HEC; TE = 10 mM HAc) and CZE (BGE = 20 mM HAc) separation of varenicline were selected considering such requirements. The UV detector was set at the constant wavelength of 237 nm. The presented CITP-CZE-UV combination enabled rapid and effective...

A view on providing care in the field of medicines in Slovakia - the pharmacist and the patient

Daniela Mináriková, Ivona Malovecká, Viliam Foltán, Ľubica Lehocká, Miroslava Snopková

Čes. slov. farm. 2013, 62(6):276-284  

The paper deals with the evaluation of care provided in a public pharmacy in terms of achieving patient / customer satisfaction. Expectations and opinions of patients are also confronted with the assumptions of pharmacists. Up to 82% of patients confirmed their satisfaction with the care given to them by the pharmacist. A key factor of patient satisfaction has proved particularly professional and human approach of pharmacist. 73.6% of patients in the survey accepted pharmacist as an expert on drugs. Pharmacist self-evaluation was more negative. Monitoring and evaluation of patient satisfaction with care delivered in the pharmacy is essential for the...

Physiological factors with impact on the drug behaviour in the gastrointestinal tract

Aleš Franc, Kateřina Dvořáčková, Martina Kejdušová, Roman Goněc

Čes. slov. farm. 2013, 62(6):243-248  

Orally administered drugs are passed through the gastrointestinal tract (GIT), which influences their next metabolism in the body. In the case of systemic administration, the drug is released from the dosage form, is dissolved and eventually absorbed. The residual amount is excreted in the faeces. The main factors influencing administered drugs are particularly pH, passage time, solubilizers or the oxido-reductive potential in different parts of the GIT. These factors are directly related to the release, absorption and stability of drugs. They can be used for simulation of the GIT environment in vitro and for the overall design of the dosage...

A chapter from the history of the pharmacy of the Brothers of Mercy in Spišské Podhradí in the 19^th and 20^th centuries

Tünde Ambrus

Čes. slov. farm. 2013, 62(6):285-290  

On the basis of archival materials, period publications and literary sources, this paper presents the data concerning the history of the pharmacy of the Hospital Order of St. John of God - the Brothers of Mercy in Spišské Podhradie in Slovakia. The Brothers of Mercy were active in Spišské Podhradie from the second half of the 17th century and in harmony with the main mission of the Order they ran a hospital and a pharmacy. The paper briefly characterizes the activities of the Brothers of Mercy in Spišské Podhradie, describes their pharmacy, its material-technical equipment and personnel carrying out its operation, focusing on the 19^th century...

Nové knihy

J. Čižmárik

Čes. slov. farm. 2013, 62(6):254  

K životnímu jubileu doc. RNDr. PhMr. Milana Čeladníka, CSc.

V. Klimešová, A. Hrabálek

Čes. slov. farm. 2013, 62(6):263  

42. sympozium klinické farmacie

J. Vlček

Čes. slov. farm. 2013, 62(6):291-293  

Padesát let seminářů a sympozií z dějin farmacie

Pavel Drábek, Václav Rusek

Čes. slov. farm. 2013, 62(6):293-294  

Rejstříky

Čes. slov. farm. 2013, 62(6):295-299