A study of a co-processed dry binder composed of microcrystalline cellulose and glycerol monostearate

Jitka Mužíková, Sandra Muchová

Čes. slov. farm. 2012, 61(5):229-233  

The paper studies the co-processed dry binder LubriTose^TM MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose MCC was lower than...

Methods of pharmaceutical technology in preparation of pellets for detection of acetylcholinesterase inhibitors

David Vetchý, Hana Leštinová, Ivana Tušarová

Čes. slov. farm. 2012, 61(5):234-239  

A variety of methods and technical equipment are currently available for checking of air contaminants. Generally, all known and sophisticated methods are based on sampling of substances in the air using different collectors or their capture in a suitable medium. However, new detection methods particularly useful in outdoor conditions are still looking for. Detection systems must be transportable, fast acting, inexpensive, sensitive and selective, and their operation should not be complicated. Such an appropriate system for the detection of carbamates and highly toxic organophosphates is detection tubes with microcrystalline cellulose pellets containing...

Bergenia genus - content matters and biological activity

Helena Hendrychová, Lenka Tůmová

Čes. slov. farm. 2012, 61(5):203-209  

Bergenia, a genus included in the family Saxifragaceae, is a valuable source of healing matters. About 30 Bergenia species are known all over the world. Scientific research is focused on five species mainly distributed in the mountains of Central and East Asia: Bergenia ciliata (Haw.) Sternb., Bergenia stracheyi Engl., Bergenia crassifolia (L.) Fritsch, Bergenia ligulata (Wall.) Engl. and Bergenia himalaica Boriss. These taxons belong to the widely used medicinal herbs in the traditional Chinese, Nepalese and Indian medicine, for therapy of cough and pulmonary diseases, to stop bleeding, to increase...

Tacrine and its derivatives in the therapy of Alzheimer's disease

Jan Korábečný, Katarína Špilovská, Ondřej Benek, Kamil Musílek, Ondřej Soukup, Kamil Kuča

Čes. slov. farm. 2012, 61(5):210-221  

Cholinesterase inhibitors have beneficial effects on the cognitive, functional, and behavioural symptoms of Alzheimer's disease (AD). Up to date, they represent almost the only drugs approved by the U.S. Food and Drug Administration agency for AD treatment. The group involves donepezil, rivastigmine and galantamine. Apart from the above mentioned cholinesterase inhibitors, memantine is used for AD treatment as well acting as N-methyl-D-aspartate (NMDA) non-competitive antagonist. Tacrine (9-amino-1,2,3,4-tetrahydroacridine) was the first cholinesterase inhibitor approved for symptomatic AD treatment. However, its several side effects (hepatotoxicity...

Important toxic and undesirable effects of medicaments in animals from the pharmacist's viewpoint

Zuzana Široká

Čes. slov. farm. 2012, 61(5):222-228  

Both veterinary and human drugs belong to the most common sources of poisoning in companion animals. The most problematic are "over the counter" drugs, mainly those from the group of analgesics, which are often given to animals by their owners who are not informed about their toxicity to animals, and those from the group of antiparasitics, which are often administered in an improper dose and to improper animal species. Pharmacists should play an important role in the education of their clients and animal owners in this field. To be able to give qualified advice and thus decrease the possibility of animal poisoning by drugs, they need to obtain sufficient...

A contribution to the development of advertising in pharmacy II. Historical development of regulation of advertising of medicinal products

Vilma Vranová

Čes. slov. farm. 2012, 61(5):240-243  

The article deals with the development of regulation of advertising of medicinal products in the Czech Lands of the Habsburg Monarchy and Czechoslovakia in the years 1775-1938. Advertising medicines had and has its specifics and its regulation had been addressed by specific standards and linked to other health laws and regulations. Regulation of advertising of medicinal products has undergone a long process from the initial total ban on advertising to the establishment of clear rules, some of which, such as restrictions on advertising prescription-only medicines only to the professional healthcare press, are still valid.

On the origin of the Czechoslovak Pharmacopoeia

Pavel Drábek

Čes. slov. farm. 2012, 61(5):244-247  

The paper summarizes the hitherto knowledge concerning the development of the first Czechoslovak Pharmacopoeia and adds some newly found facts. It is mainly based on the found correspondence demonstrating the care of the Czech Society of Pharmacists for a good standard of the Pharmacopoeia.

Klimas J. (zostavovateľ): 60 rokov Farmaceutickej fakulty Univerzity Komenského v Bratislave (1952-2012). Bratislava: Univerzita Komenského 2012

J. Čižmárik

Čes. slov. farm. 2012, 61(5):250  

76^th Prague Meeting on Macromolecules

M. Rabišková

Čes. slov. farm. 2012, 61(5):248  

EUFEPS a 9. středoevropské sympozium farmaceutické technologie

M. Rabišková

Čes. slov. farm. 2012, 61(5):249