Česká farmaceutická společnost ČSL JEP vzpomněla 140. výročí svého založení

Čes. slov. farm. 2011, 60(6):267-268  

Analytical profile of 1-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(3-tri-fluoromethylphenyl)piperazinium chloride

Ivan Malík

Čes. slov. farm. 2011, 60(6):283-289  

The purpose of the paper was the completing of the experimentally estimated physicochemical descriptors spectrum of 1-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(3-trifluoromethylphenyl)piperazinium chloride (labelled as 8e), an effective, highly lipophilic compound against non-tuberculous M. kansasii My 235/80. The identity of the structure 8e was verified by ¹H- and ¹³C-NMR spectral data, IR spectrometry and by elemental analysis as well. The readout from mass spectrometry confirmed an existence of the molecular ion [M + H⁺]⁺. The purity of the evaluated compound 8e...

Study of local anesthetics - Part 195. Study of micellization of pentacainium chloride in methanol and ethanol solutions

Jana Gališinová, Jozef Čižmárik, Fils Andriamainty, Ivan Malík

Čes. slov. farm. 2011, 60(6):290-295  

The critical micellar concentrations of pentacainium chloride in methanol and ethanol solutions with different concentrations were determined by the spectrophotometric method in the UV region of the spectrum at the temperature range of T = 278.15-308.15 K and pH ≈ 4.5-5.0. The dependence of cmc on temperature T turned out to be U-shaped. The influence of the n-alkanols, methanol and ethanol, on the critical micellar concentration was studied. The cmc values show that micelle formation occurred more easily in methanol than in ethanol solutions. Simultaneously the influence of various concentrations of alcohols was studied. The critical...

On the question of special over-the-counter drugs

Čes. slov. farm. 2011, 60(6):269-275  

In the Czech Republic, special non-prescription over-the-counter (OTC) drugs are defined as the preparations which, according to their registration, can be sold over the counter without a prescription outside pharmacies. The paper outlines the development of the question of human and veterinary OTC drugs (lists of special OTC drugs, good practice of sellers of special OTC drugs) and compares the number and structure (indication group, selected medicinal products, dosage form) of human and veterinary drugs included into this group.

Clinical significance of cytochrome P450 genetic polymorphism - part IV. Cytochrome P450 3A4 and 3A5

Jana Ďuricová, Milan Grundmann

Čes. slov. farm. 2011, 60(6):276-282  

The enzymes of cytochrome P450 3A subfamily are responsible for the metabolism of about 50% of commonly used drugs. High inter-individual variability in the activities of these enzymes has been described. The last fourth part of this review focuses on the influence of genetic polymorphism of CYP3A4 and CYP3A5 enzymes on drug effect.

Medicinal preparations in this country at the end of the 18th century. Part II - Semisolid and solid dosage forms

Pavel Drábek

Čes. slov. farm. 2011, 60(6):296-302  

This paper links up with Part I and deals with the other medicinal preparations, which were originally included in the Austrian book of prescriptions Dispensatorium pharmaceuticum Viennense and then taken over to the Austrian provincial pharmacopoeia Pharmacopoea austriaco-provincialis, repeatedly published between 1774 and 1794. This part discusses semisolid dosage forms, e.g. Electuaria, Mella, Pulpae, Unguenta, and solid dosage forms, e.g. Emplastra, Extracta, Morsulae, Pilulae, Pulveres, Rotulae, Tabulae, Trochisci. The final part of the paper also lists chemical substances (Chymica et consimilia) prepared in...

Response to the paper "Viscosity and consistence measurements following Ph.B. 2009" (Čes. Slov. Farm., 2011; 60, 241-246)

Čes. slov. farm. 2011, 60(6):289  

The paper responds to the paper entitled Viscosity and consistence measurements following Ph.B. 2009 by E. Šnejdrová and P. Pohlová published in this journal (Čes. Slov. Farm., 2011; 60, 241-246). The pharmacopoeia texts which were criticized had been revised about a year before the publication of their paper and the majority of mistakes were corrected in Ph.B. 2009 - Add. 2010 valid from 1 September 2010.

Jesenský, M.: Alchýmia v Čaplovičovej knižnici

Čes. slov. farm. 2011, 60(6):295  

Pracovný deň Technologickej sekcie Slovenskej farmaceutickej spoločnosti. Liekové formy súčasnosti (a budúcnosti) - násobné liekové formy, transdermálne liekové formy. Bratislava, 20. septembra 2011

Čes. slov. farm. 2011, 60(6):303-309  

Zprávy

Čes. slov. farm. 2011, 60(6):310-311  

AUTORSKÝ REJSTŘÍK

Čes. slov. farm. 2011, 60(6):314-315  

VĚCNÝ REJSTŘÍK

Čes. slov. farm. 2011, 60(6):316