Časopis Česká a slovenská farmacie v roce 2010

Čes. slov. farm. 2010, 59(1):3  

Preparation and evaluation of hydrophilic cream with propolis extract

J. Bernatonienė, J. Davalgienė, R. Masteiková, J. Muselík, G. Drakšienė, R. Lazauskas, R. Pečiūra, Z. Chalupová

Čes. slov. farm. 2010, 59(1):11-17  

The aim of the study was the preparation and evaluation of a multifunctional hydrophylic cream. The cream was stabilised with a complex emulsifier and carbomer gel, both formed in situ during preparation. The active ingredient was a thick propolis extract in the concentration of 0.8%. The cream with propolis showed antioxidant activity due to the total phenolics content, total flavone and flavonol content. The cream base and the cream with the propolis extract were prepared using various mixing velocities. The properties of preparations studied as response variables were: resistance to centrifugation, viscosity and internal phase particles (droplets)...

Evaluation of the reactivating efficacy of selected reactivators of paraoxon-inhibited acetylcholinesterase in vitro

O. Holas, K. Musílek, V. Opletalová, K. Kuča

Čes. slov. farm. 2010, 59(1):18-22  

Organophosphorus pesticides (OPs) are ranked among the group of highly toxic irreversible inhibitors of acetylcholinesterase (AChE). The causal drugs in OPs intoxications are oxime reactivators of AChE. The reactivating efficacy of five newly prepared bispyridinium reactivators of acetylcholinesterase was tested on a model of a paraoxon-inhibited enzyme. The reactivating efficacy was tested by means of the standard in vitro test, the laboratory rat brain homogenate being used as the source of acetylcholinesterase. The result were compared with five commercially available AChE reactivators.

Long-term trends in the utilization of beta-blocking agents in the Czech Republic

B. Kořístková, M. Grundmann, D. Šalounová

Čes. slov. farm. 2010, 59(1):23-30  

To study long term trends in the utilization of beta-blockers (ATC group C07) with regard to a possible influence of the health reform in 1992 on the availability of drugs.Method: The utilization of C07 was expressed in the defined daily doses per thousand inhabitants and a day (DDD/TID) in the Czech Republic (I), and in DDD per 100 bed days (DDD/100 BD) in the University Hospital (OUH) Ostrava (II). ATC/DDD index: 2004. 10 mg was used as the DDD equivalent for metipranolol. The sources of data were: I. The SUKL database (wholesale data), the UZIS database (prescriptions), and II. The hospital request forms. Observed period: 1985-2007. The statistical...

On the content of the national section of the Czech Pharmacopoeia 2009

J. Šubert

Čes. slov. farm. 2010, 59(1):4-6  

In comparison with the Czech Pharmacopoeia 2005 and its Supplements, the national section of the Czech Pharmacopoeia 2009 does not include any really substantial changes; its content confirms the stagnation in this field of pharmacopoeial work in the Czech Republic. The paper highlights several changes, discusses possible causes of the unsatisfactory state of the updating of the national section of the Czech Pharmacopoeia and stresses the necessity of its solution.

Present-day approaches to pharmacotherapy - pharmaceutical care or drug management?

J. Kolář, B. Macešková

Čes. slov. farm. 2010, 59(1):7-10  

Optimization of pharmacotherapy has been traditionally contributed to by the physician, and in the concept of clinical pharmacy also by the pharmacist. As to the decision-making about pharmacotherapy, the idea of pharmaceutical care includes also the patient and as to the drug therapy management also the payer of the provided health care (health insurance companies). The terms pharmaceutical care and drug management are very close to each other but not identical, though they are often used as synonyms in the professional literature. The paper attempts to point out both the identical and different features of both concepts, the competence of individual...

Pracovní den sekce technologie léků České farmaceutické společnosti ČLS JEP. Pokroky v lékových formách

Čes. slov. farm. 2010, 59(1):34-38  

Vybrané kurzy, stáže a semináře IPVZ - 1. pololetí roku 2010

Čes. slov. farm. 2010, 59(1):41-43  

Jak se hlásit na vzdělávací akce IPZV

Čes. slov. farm. 2010, 59(1):43-44  

Životné jubileum doc. RNDr. Lýdie Bezákovej, Ph.D.

J. Čižmárik

Čes. slov. farm. 2010, 59(1):44-45  

Životné jubileum prof. RNDr. Daniela Grančaia, CSc.

J. Čižmárik

Čes. slov. farm. 2010, 59(1):45-46  

XLIX. sympozium z historie farmacie a veterinární medicíny

M. Lisá

Čes. slov. farm. 2010, 59(1):39  

13. kongres nemocničních lékárníků

M. Lžičař

Čes. slov. farm. 2010, 59(1):39-40  

Ze zasedání Výboru České farmaceutické společnosti

P. Komárek

Čes. slov. farm. 2010, 59(1):40  

Studies on local anaesthetics: Part 191. Optimization of the composition of hydrogels from the standpoint of flow properties for trimecaine and terbinafine

P. Herdová, Z. Vitková, J. Čižmárik

Čes. slov. farm. 2010, 59(1):31-33  

The study was concerned with the formulation of the local anaesthetic agent trimecaine and the antimycotic agent terbinafíne into hydrogels possessing the optimal flow properties. The gelling agents were the cellulose derivatives hydroxyethyl cellulose and hydroxypropyl cellulose. The evaluation included the samples in various combinations and concentrations prepared in such a way to produce the most suitable hydrogel viscosity with regard to the intended use. On the basis of the evaluation of the rheological properties, the suitable gelling base for the local anaesthetic trimecaine proved to be the combination of 1% trimecaine and 2% hydroxyethyl...