Contribution of allergen immunotherapy using Phostal in the treatment of seasonal allergic rhinitis (two years of use)

L. Bartošíková, J. Nečas, T. Bartošík, M. Pavlík, J. Fráňová

Čes. slov. farm. 2008, 57(2):99-102  

Allergen immunotherapy consists in the administration of the appropriate allergen to which the patient is hypersensitive. The objective is to induce immunological tolerance of the organism. In the present study, the effect of the administration of Phostal on the occurrence of seasonal symptoms of pollinosis in a group of 35 outpatients was observed during two years. The substance was administered according to the regular dosage schedule, all year round. The results of the study have demonstrated a significant effect of the product on the decrease in the occurrence of observed objective symptoms of the disease, starting already from the first year of...

Standard prescriptions for the formulation of medicinal preparations in pharmacies I. Suspensions for dermal administration

J. Šubert, J. Kolář, V. Vašková

Čes. slov. farm. 2008, 57(2):55-57  

The paper summarizes the present state of standard prescriptions for the formulation of suspensions for dermal administration in the Czech Republic and compares it with the NRF (Neues Rezeptur-Formularium in Deuscher Arzneimittel-Codex) standard prescriptions. The analysis of medical prescriptions for suspensions for dermal administration dispensed in the pharmacies of the Czech Republic has revealed that 18.8 % of the prescriptions were for 50% suspension of zinc(II) oxide in sunflower oil. This preparation should therefore become a candidate for standardization as a monograph in the national part of the Czech Pharmacopoeia.

Interaction of 1,4-dihydropyridines with ion channels

L. Veizerová, J. Světlík, V. Kettmann

Čes. slov. farm. 2008, 57(2):58-62  

The pharmacology of dihydropyridines in the cardiovascular system is widely known and the effects on L-type channels are well researched. There is far less information about the action of dihydropyridines on other classes of voltage-gated calcium channels. This article aims to bring more information about dihydropyridine derivates action on voltage-gated calcium channels or on Na⁺ a K⁺channels.

Semisynthetic cellulose derivatives as the base of hydrophilic gel systems

M. Bajerová, J. Gajdziok, K. Dvořáčková, R. Masteiková, P. Kollár

Čes. slov. farm. 2008, 57(2):63-69  

The field of drug technology widely ulilizes gel systems of high-molecular substances, which have a number of advantages, such as low toxicity, availability, unique physical properties, biocompatibility, mucoadhesivity, and others. Gel systems are used in the field of local as well as general therapy, in both shape-specific and shape-non-specific dosage forms, in medicaments of the first, second, and third generations. An important group of gels employed in pharmacy are hydrophilic gels or hydrogels, most frequently composed of hydrophilic polymers of natural, semisynthetic and synthetic origin. Though cellulose derivatives as the representatives of...

Radiolabelled peptides in the diagnosis and therapy of tumours

J. Cihlo, M. Lázníček

Čes. slov. farm. 2008, 57(2):70-77  

In the last two decades, radiolabelled receptor-specific peptides have profiled themselves as excellent tools that have expressively increased the diagnostic and therapeutical possibilities of tumours predominantly of neuroendocrine origin. The aim of this review paper is to transparently inform the Czech scientific fraternity about the significance and limitations of the use of this group of radiopharmaceuticals in clinical practice.

Medicinal plants and diabetes mellitus

V. Suchý, M. Žemlička, E. Švajdlenka, J. Vančo

Čes. slov. farm. 2008, 57(2):78-84  

Diabetes mellitus is a group of chronic metabolic disorders. Hyperglycaemia and other related disturbances in the body's metabolism can result in serious damage to many of the body's systems, especially the blood vessels and nerves. Across the globe, there are an estimated 150 million people suffering from diabetes mellitus, which causes about 5 % of all deaths globally each year. From many reports it is clear that diabetes will be one of the major diseases in the coming years. Existing treatment options are costly, and have limited palliative effects. It stimulates finding new medicines or suitable prophylactic treatments. Plant-based medicinal products...

Modern instrumentation for the studies of isoflavones

J. Vacek, B. Klejdus, L. Lojková, V. Kubáň

Čes. slov. farm. 2008, 57(2):85-94  

Isoflavones belong to the natural substances exhibiting a number of physiological effects in living organisms. The substances are synthesized in plant tissues as protective agents against biotic stress (i.e. bacterial infection). Isoflavones are also an important dietary constituent in human nutrition. The review discusses modern trends in the studies of isoflavones in plant materials and foodstuffs and procedures for chemical analyses of isoflavones in human body fluids and plant tissues. Highly effective extraction and purification techniques, i.e. solid-phase extraction (SFE), accelerated-solvent extraction (ASE), and Soxhlet extraction, are presented....

Lactobacilli and their probiotic properties

H. Kiňová Sepová, A. Bílková, M. Bukovský

Čes. slov. farm. 2008, 57(2):95-98  

Lactobacilli rank among lactic acid bacteria, fermenting saccharides to produce lactic acid. The individual species and strains differ by the profiles of fermented saccharides, but this property is not sufficient for the identification at the species level. The species and strains differ in the 16S rDNA sequence and in the intergenic space between 16S and 23S rDNA, which make their differentiation and identification possible. Some representatives of the genus Lactobacillus are included in probiotic preparations with regard to their beneficial health effects on the human and animal organisms. For example, they are able to interact with the immune system...

Nové knihy

Čes. slov. farm. 2008, 57(2):62  

Nové knihy

Čes. slov. farm. 2008, 57(2):84  

Sedmdesátka doc. RNDr. Jiřího Hartla, CSc.

V. Opletalová, M. Doležal

Čes. slov. farm. 2008, 57(2):103  

K životnímu jubileu prof. RNDr. Rolfa Karlíčka, DrSc.

P. Solich, M. Pospíšilová

Čes. slov. farm. 2008, 57(2):103-104  

Ze zasedání Výboru České farmaceutické společnosti

Čes. slov. farm. 2008, 57(2):94