ČASOPIS ČESKÁ A SLOVENSKÁ FARMACIE V ROCE 2008

Čes. slov. farm. 2008, 57(1):3  

Effects of auxins on growth and scopoletin accumulation in cell suspension cultures of Angelica archangelica L.

T. Siatka, M. Kašparová

Čes. slov. farm. 2008, 57(1):17-20  

Scopoletin is a coumarin possessing many interesting biological effects, e.g., spasmolytic, anti-inflammatory, antimutagenic, antioxidant, antifungal, apoptosis-inducing, antiproliferative, acetylcholinesterase-inhibitory, and hypouricemic activities. Plant tissue cultures represent a promising alternative source of valuable plant-derived substances. A number of physical and chemical factors influence the cell growth and secondary metabolite biosynthesis in plant tissue cultures. The mechanism of their action is not completely understood. Besides other factors, plant growth regulators and light conditions play an important role. Effects of four auxins...

A study of the properties of tablets made of directly compressible maltose

J. Mužíková, J. Balhárková

Čes. slov. farm. 2008, 57(1):21-27  

The paper deals with the study of the strength and disintegration time of tablets made of directly compressible maltose Advantose 100. It studies the differences of the effects of two types of lubricants, magnesium stearate and sodium stearylfumarate, on the above-mentioned properties, and it also tests the mixtures of the substance with microcrystalline cellulose Vivapur 102 in a ratio of 1:1 and with ascorbic and acetylsalicylic acids. The compacts are obtained by using three compression forces, excepting mixtures with active ingredients, where one compression force is used. In the compression forces of 6 and 8 kN, no statistically significant difference...

Substances Modifying the Activity of Caspases

T. Bartl, P. Žádníková, R. Jiříkovská, B. Maroušková, L. Beneš

Čes. slov. farm. 2008, 57(1):29-34  

Caspases are enzymes which play a key role in programmed cell death - apoptosis. Dysregulation of this process results in a series of disorders in which apoptosis is involved in pathogenesis. Diseases could be divided into two groups - diseases with pathological inhibition of apoptosis (cancer, some autoimmune disorders) and diseases with pathological induction of apoptosis (neurodegenerative disorders, AIDS). The paper lists the most significant activators and inhibitors of caspases as they control apoptosis and hence they are widely studied nowadays. The effects of stobadine, theophylline and adenine derivatives on the activity of caspase 1 was investigated...

Antioxidant activity of tinctures prepared from hawthorn fruits and motherwort herb

R. Masteiková, J. Muselík, J. Bernatonienė, D. Majienė, A. Savickas, F. Malinauskas, R. Bernatonienė, R. Pečiūra, Z. Chalupová, K. Dvořáčková

Čes. slov. farm. 2008, 57(1):35-38  

The paper aimed to determine and compare the antioxidant activity of two tinctures and selected flavonoids present in the tinctures. The tinctures were prepared from hawthorn fruits and motherwort herb. The group of selected flavonoids included rutin, quercetin, hyperosid, epicatechine, and procyanidin B2. Two methods were employed to determine antioxidant activities: the inhibition of peroxynitrite-induced nitration of tyrosine was measured, and the ability to quench radicals was examined by of the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Both tinctures under study were able to quench radicals and reactive forms of oxygen and nitrogen....

Signal pathways of cell proliferation and death as targets of potential chemotherapeutics

A. Repický, S. Jantová, V. Milata

Čes. slov. farm. 2008, 57(1):4-10  

The purpose of this paper is to review current information concerning signal transduction pathways of cell proliferation and cell death applicable in the research of antitumor compounds with a specific effect. Actually, cancer counts among the world gravest diseases. Research of the mechanisms of action of chemotherapeutics helps us to find compounds with high cytotoxic activity to tumor cells and low or no cytotoxicity to normal cells. Many present studies deal with the ability of drugs to hit the proliferation signal pathways or cell death pathways specifically. Various proliferation signal pathways have been identified, e.g. pathways of mitogen-activated...

Hemostatic effects of oxidized cellulose

P. Kollár, P. Suchý, J. Muselík, M. Bajerová, P. Havelka, T. Sopuch

Čes. slov. farm. 2008, 57(1):11-16  

Oxidized cellulose ranks among nontoxic and biocompatible biopolymers. Oxidized regenerated cellulose (ORC) is manufactured from regenerated cellulose derived from wood pulp containing about 50% of cellulose. To obtain purified cellulose, it is necessary to decompose it in a chemical way and subsequently put it together to make "regenerated" cellulose. Thanks to its good hemostatic effects, high biosolubility and biodegradability, antioxidant and wound-healing properties, oxidized cellulose represents a suitable means for the therapy of bleeding conditions in various fields of medicine. In addition, the confirmed bactericidal effects of oxidized cellulose...

Nové knihy

Čes. slov. farm. 2008, 57(1):16  

Nové knihy

Čes. slov. farm. 2008, 57(1):50  

POKROKY V LÉKOVÝCH FORMÁCH - PRACOVNÍ DEN SEKCE TECHNOLOGIE LÉKŮ ČFS JEP

Čes. slov. farm. 2008, 57(1):39-44  

Abstrakta z akcí ČFS v časopisu Česká a slovenská farmacie

Čes. slov. farm. 2008, 57(1):44  

Mezinárodní kongres historie farmacie

Čes. slov. farm. 2008, 57(1):46  

Cena pro doc. RNDr. PhMr. Václava Ruska, CSc.

M. Lisá

Čes. slov. farm. 2008, 57(1):46-47  

Jubileum doc. RNDr. Ruženy Čižmárikovej, CSc.

Čes. slov. farm. 2008, 57(1):47-48  

Životné jubileum prof. RNDr. Vladimíra Špringera, CSc.

P. Kovács

Čes. slov. farm. 2008, 57(1):48-49  

Ze zasedání výboru České farmaceutické společnosti

Čes. slov. farm. 2008, 57(1):45  

Podvýživa a nevhodná výživa

Čes. slov. farm. 2008, 57(1):16