Czech and Slovak Pharmacy, 2001 (vol. 50), issue 4
Articles
Advances in the Development of New Antituberculotics from the Group of Ortho-Condensed Heterocyclic Compounds. Part 1. Compounds Containing One Heteroatom in the Six-Membered Ring
K. Waisser, O. Bureš, P. Holý
Čes. slov. farm. 2001, 50(4):159-165
Tuberculosis and other mycobacterial diseases are considered to be one of the most importantproblems of contemporary health service. Since 1985 and particularly in the 1990s and at presentthe search for new structures of antimycobacterial agents have ranked among the foremost areasof chemotherapeutic research. The present review paper is already the 16 th communication ina group of review papers about the development of new antituberculotics in recent 15 years. Theliterature search is based on the journal Chemical Abstracts, Current Awareness in Biomedicine,part Mycobacteria, and original papers. Current Awareness in Biomedicine is, however, a veryimperfect...
Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics
T. Rojkovičová, J. Lehotay, J. Čižmárik
Čes. slov. farm. 2001, 50(4):166-172
The present review paper describes the properties of the macrocyclic antibiotics vancomycin,teikoplanin, and ristocetin A, which can be used as stationary phases for separation of theenantiomers of drugs containing a stereogenic centre. It analyzes the results obtained in theseparation of amino acids, its derivatives, loxiglumide, clenbuterol, practolol, carnitine, levodopa,methyldopa, ceftazidine, alkoxyphenylcarbamic acid derivatives, dichloroprop, ketoprofen, warfarin, and ergot alkaloids by means of high-performance liquid chromatography (HPLC)
Phytotherapeutic Aspects of the Diseases of the Circulatory System7. Schisandra chinensis (TURCZ.) BAILL.: Its Constituents and Their Biological Activity
L. Opletal, M. Křenková, P. Havlíčková
Čes. slov. farm. 2001, 50(4):173-180
Schisandra chinensis (TURCZ.) BAILL., originally a Japanese-Manchurian endemite, yields a vegetable drug (Schisandrae fructus) with a number of very utilizable therapeutic effects. The paper reports the results of phytochemical and pharmacological-toxicological studies approximately from the year 1990 carried out both with the drug and, in particular, the principal isolated lignans of thedibenzo[a,c]cyclooctadiene type. The results confirm the validity of the historical use of the drug, inparticular as a hepatoprotective, adaptogenic, and antioxidative agent. It is obvious that a very positive therapeutic effect based on the use of a complex mixture...
Unused Drugs Returned to Pharmacies I.
J. Kolář, L. Chybová, D. Holečko
Čes. slov. farm. 2001, 50(4):181-187
Drugs that have not been administered and have been stockpiled in households represent a medical,professional, and ecological problem. The present paper analyses and evaluates these drugs fromqualitative, quantitative, and financial aspects. The material under study consisted of drugsreturned to one pharmacy within a period of 1.5 months (April-May) in the year 1999. Out of set I(1 091 packages), 721 packages (66.1 %) were used and 370 (33.9 %) packages were original, i.e.unused. The expiration period was over in 78.3 %, 16.8 % could still be used, and in 4.9 % it wasimpossible to determine their expiration period. The value of the returned drugs was...
Pharmacotherapy of Osteoporosis in Out-Patient Practice and Its Pharmaceutical Aspects
E. Baranovičová, N. Luknárová, V. Foltán
Čes. slov. farm. 2001, 50(4):188-192
Within the framework of studies of pharmacotherapy of the diseases of the muscular and skeletalsystem, the paper aimed to analyze the pharmacotherapy of osteoporosis. The significance of theproblems in the field of research of epidemiology of osteoporosis requires the use of all availablemethods. With regard to the fact that the epidemiological situation in osteoporosis i s also reflectedin the consumption of drugs, the paper aimed to contribute to the solution of the problem by meansof an analysis of the pharmacotherapy of osteoporosis. The results of the analysis have confirmedthe relationship between the prevalence of the disease of osteoporosis...
Effect of Losartan on the Antioxidant Status of Rats with Diabetes Mellitus
A. Liptáková, O. Uličná, Z. Ďurčková, P. Božek, O. Vančová
Čes. slov. farm. 2001, 50(4):193-196
The aim of this study was to monitor the effect of the administration of antihypertensive druglosartan on: (1) the antioxidant status of rats with experimental insulin-dependent diabetesmellitus; (2) oxidative damage which is represented by the production of compounds which can reactwith thiobarbituric acid (TBARP), and (3) some metabolic parameters. Losartan administration didnot significantly influence the concentration of glucose, cholesterol, triacylglycerol, and uric acid inthe plasma of control and diabetic animals. In the liver tissue, the concentration of triacylglycerolsdecreased after losartan administration, but the concentration of cholesterol...
Analytical Evaluation of the Substance BL 443 Pivalate
Ž. Bezáková, M. Stankovičová, J. Csöllei
Čes. slov. farm. 2001, 50(4):197-202
The paper presents the results of an analytical evaluation and a study of some physicochemicalproperties of a new potential drug of the prodrug type Πthe substance BL 443 pivalate with anassumed antidysrhythmic effect. The structure of the substance has been confirmed by elementalanalysis, IR and UV spectroscopy. The following parameters were determined: melting point,solubility, dissociation constant, experimental partition coefficient in four different systems, and surface activity. The chromatographic behaviour of the drug on a thin layer (adsorption andpartition chromatography) was also investigated. Acidimetric titration in non-aqueous...
Antiradical Activity of Some Antiulcer and Local-Anaesthetic Active Substances
J. Dovolil, L. Beneš
Čes. slov. farm. 2001, 50(4):203-205
The free radical scavenging effect of the hydrochloride of (±)-trans-2-(1-pyrrolidinyl-) cyclohexylesterof 3-(n)-pentyloxy carbanilic acid, pentacaine (trapencaine I.N.N), and its derivatives and othersubstances, lidocaine, stobadine, mannitol, and ascorbic acid was tested in the presence of diphenyl-p-picrylhydrazyl (decrease in absorbance). In this method, more pronounced antiradical activitywas observed with trapencaine, more effective than stobadine, ascorbate, and mannitol. Trapen-caine derivatives and lidocaine were less effective in comparison with trapencaine. After introducinga methylene group into the hydrophilic moiety of the trapencaine...