Czech and Slovak Pharmacy, 2001 (vol. 50), issue 1
Articles
Development of Tuberculosis Chemotherapy
J. Hladůvková, K. Waisser, J. Kaustová
Čes. slov. farm. 2001, 50(1):4-11
The paper belongs to the series of review papers entitled "Substances with Antituberculous Effects".In contrast to other communications of the series, it deals with the present state of tuberculosis andthe development of its chemotherapy. Whereas the other review papers of the series survey thedevelopment of structures of novel potential drugs, the present paper aims to show possibletreatment of tuberculosis and its problems, concentrating on the contemporary situation.
Pharmaceutical Importance of Allium sativum L.
M. Sovová, P. Sova
Čes. slov. farm. 2001, 50(1):12-20
The paper sums up new experimental knowledge concerning the individual groups of organic sulfurous substances of the garlic: sulfoxides, thiosulfinates, ajoens, vinyldithiines, alkyl and alkenesulfides and glutamylpeptides of sulfurous amino acids, their transformation reactions (based on the temperature, pH, extraction medium, and time) and the final products of transformations (Scheme 1, 2). It deals with the activity of the enzyme alliinase necessary for the transformation of sulfoxides present in the whole garlic, its isolation and stability as well as the stability of the dominant thiosulfinate allicin in various media and simulated body fluids....
A Review of Radiodiagnostics of Inflammation
K. Nováková, M. Lázníček
Čes. slov. farm. 2001, 50(1):21-27
Inflammation is a complex reaction of the organism which develops as a response to invasion of aninfectious subject or as a response to injury to cells or tissues. Correct and early localization ofinfection or an inflammatory lesion allows removing the inflammatory cause quickly. Over the recentthirty years, a wide range of radiopharmaceuticals, more or less applicable in scintigraphic imagingof inflammatory and infectious diseases, have been developed. The aim has been to develop newsubstances that are non-toxic, do not provoke immune reactions, and produce a minimal absorbedradioactive dose. Furthermore, these substances should accumulate significantly...
Use of Synthetic Biodegradable Polymers in Medicine
J. Maxa, M. Dittrich
Čes. slov. farm. 2001, 50(1):28-34
Synthetic biodegradable polymers, such as polyesters, polyanhydrides, polyorthoesters, polycarbonates, polyphosphoesters, polyphosphazenes, polyesteramides, polyalkylenoxalates, polyalkylcyanoacrylates, etc., are represented as materials which are being tested for use, or which have been already used in surgery, orthopaedics, and pharmacy. A particular attention is devoted to their usein the preparation of systems with prolonged release or with targeted biodistribution of active ingredients.
Calorimetric Evaluation of Directly Compressed Tablets
M. Řehula, J. Lavická, M. Musilová
Čes. slov. farm. 2001, 50(1):35-37
The paper studies the effect of the type of the disintegrating substance and the lubricant on thedestruction heat of tablet materials and tablets. Destruction heat was determined by means ofisoperibolic calorimetry. Tablet materials and tablets contained Avicel PH 101 as the dry binder,10% of Primojel, Ac-Di-Sol, or Polyplasdone XL as disintegrating substances, and 5% of magnesiumstrearate or sodium laurylsulfate as the lubricants. The sum of destruction heats of the individualauxiliary substances equalled the found values in tablet materials and tablets. In tablets, in contrastto tablet materials, values of destruction heat higher by 57.9 % were found....
Prednicarbat and Cetirizin Dihydrochloride in the Treatment of Acute Stage of Atopic Eczema in Children
L. Bartošíková, L. Fráňa, J. Nečas, P. Fráňa, J. Dzúrová, J. Petrželková, P. Kollár
Čes. slov. farm. 2001, 50(1):38-40
The aim of the study was to monitor the impact of local application of prednicarbat (Dermatop,Hoechst-Biotika) and oral administration of cetirizin (Zyrtec, UCB) on the development of the acute stage of atopic eczema (AE) or acute exacerbation of the chronic form of AE in two groups of patients. Effectiveness and safety of both preparations were being evaluated in 80 children undergoing anoutpatient treatment. In the first group, only prednicarbat cream was applied to affected places twice a day for a maximum of 10 days, while in the other group also cetirizin was administered once a day in a dosage according to the patient's age. On the treated places,...
Effect of the Biotic Elicitor Candida utilis on the Production of Anthracene Derivativesby the Tissue Culture of Rheum palmatum L.
M. Kašparová, T. Siatka
Čes. slov. farm. 2001, 50(1):41-45
The paper studied the effect of the homogenate of Candida utilis on the production of anthracene derivatives by the callus and suspension culture of Rheum palmatum L. of different age and origin. The culture was cultivated on a Murashige-Skoog medium with an addition of 10 mg.l-1 of a-naphthylacetic acid. A positive effect on the production was caused mainly by the elicitation of the suspension culture. The maximal content of anthracene derivatives (1.346%), found by photometric determination according to PhBs 4, was demonstrated after 6-hour action of the homogenate of Candida utilis of a concentration of 0.143 mg/30 ml of the medium in an eight-year...
Content and Quality of the Essential Oil of Melissa officinalis after the Administrationof Rastin 30 DKV
Š. Vaverková, M. Hollá, J. Tekeľ
Čes. slov. farm. 2001, 50(1):46-50
The paper deals with the evaluation of the content and quality of the essential oil of Melissa officinalis in various leaf insertions in the course of the ontogenetic development of the plant. The quality of the drug after the administration of the preparation Rastin 30 DKV in the form of granules was not changed in comparison with control samples. The experimental work, subsequent analysis of samples, and evaluation of results led to conclusions important from the viewpoint of significant changes in the content and composition of the essential oil taking place in the plant in the course of the vegetation period.
Polyphenolic Compounds from Hamamelis virginiana L.
D. Košťálová, E. Mišíková, G. Gáborová
Čes. slov. farm. 2001, 50(1):51-53
Two phenolic acids and two flavone aglycones were isolated from the aboveground part of Hamamelis virginiana L. and identified with the use of thin-layer chromatography, melting points, and spectroscopic methods as gallic acid, ethyl gallate, quercetin, and kaempferol.