Czech and Slovak Pharmacy, 2000 (vol. 49), issue 4
Articles
Interactions Between Medicinal Plants and Drugs
L. Tůmová
Čes. slov. farm. 2000, 49(4):162-168
At present the use of medicaments of plant origin is on the increase. It is therefore necessary to takeinto consideration that there exist known as well as potential interactions between the medicamentof the medicinal plant. The problematic plants include Echinacea, Allium cepa, Gingko biloba, Panaxginseng, as well as Hypericum perforatum, Valeriana officinalis, or Glycyrrhiza glabra. Its useshould be limited, or completely excluded in the cases of simultaneous therapy with, e.g., warfarin,hepatotoxically acting medicaments, MAOI inhibitors, phenelzin sulphate, or phenytoin, as theymay decrease of completely eliminate the therapeutic effect of the...
Curcumin as a Potential Antioxidant Agent
J. Stano, D. Grančai, K. Neubert, J. Kresánek
Čes. slov. farm. 2000, 49(4):168-170
Curcuma vera is one of the medicinal plants of traditional Chinese medicine. The plant is the naturalsource of one of natural antioxidative agents - curcumin. The present paper summarizes informationabout the properties of curcumin and presents the characteristics of Curcuma vera, its producer.
Role of Aminooxidase in Alkaloid Biosynthesis
A. Bílková, L. Bezáková, F. Bilka, M. Pšenák
Čes. slov. farm. 2000, 49(4):171-176
The review paper deals with the contemporary theoretical knowledge about the role of Cu-amino-oxidase in the biosynthesis of alkaloids in plants. In the biosynthesis of tropane and piperidinealkaloids, aminooxidase participates in the conversion of amines into aldehydes which are the firstimportant intermediates in the biosynthesis of these alkaloids. Norkoklaurine, the precursor ofbenzylisoquinoline alkaloids, is formed by condensation of dopamine and tyral. In the biosynthesis of benzylisoquinoline alkaloids of protoberberine and berberine type, tyral, the aldehyde condensa-tion unit, is produced by the action of aminooxidase. In morphinan alkaloids,...
Effects of a (4-Fluorophenyl)piperazine Derivative (Substance IIIv) on the Cardiovascular Functions
R. Mlynárová, D. Ťažká, E. Račanská, J. Kyselovič, P. Švec
Čes. slov. farm. 2000, 49(4):177-180
The present paper links up with the study of principal pharmacological effects of newly synthesized aryloxyaminopropanols substituted with 1,4-piperazine derivatives in the hydrophilic moiety of the molecule. The substance with the working name IIIv showing the highest b-adrenolytical andvasodilating effect underwent further pharmacological evaluations with the aim of contributing to the elucidation of the mechanism of its action. After 7-day administration of the substance in two doses (5 and 50 mg.kg-1), the changes in the reactibility of arterial preparations were investigated on three models of the contraction of the isolated rat aorta (KCl, noradrenaline,...
Fractal Dimension of Powders for Pharmaceutical Dusting Powders
Z. Zatloukal
Čes. slov. farm. 2000, 49(4):181-184
The paper examines the use of the fractal dimension for the expression of the shape of random aggregates of primary particles of four powders for pharmaceutical dusting powders. The values within a range from 1.14 to 1.24 are compared with the results of the equilibrium gravitational classification within a range from 15 to 45 mm. Vacillation of the fractal dimension is influenced by the values of the specific surface determined from the parameters of the RRS-distribution of elutriation. The fractal dimension extends the morphological characteristics of powders. For the needs of pharmaceutical technology it is, however, necessary to specify better...
Physicochemical in vitro and in vivo Investigation of the Depot Formation of Cinchocaine in Atelocollagen Felt
J. Ludvík, J. Prokeš, A. Galatík, J. Fanta
Čes. slov. farm. 2000, 49(4):185-189
The paper presents an introductory physicochemical study dealing with the preparation of atelocol-lagen felt saturated with local anesthetics, with the modelling of the release of the anesthetic fromthe collagen matrix in vitro, and with the checking of the corresponding analytical procedures(dc-polarography and UV-VIS spectrophotometry) for the determination of cinchocaine. The studyis supplemented with experiments in vivo that confirm the usability of the new material for thedepot formation of local anesthetics.
Analysis of a Cardioplegic Solution Using Capillary Isotachophoresis
I. Valášková, R. Adamčová, S. Barošová, E. Havránek
Čes. slov. farm. 2000, 49(4):190-194
The method of capillary isotachophoresis was employed to analyze a cardioplegic solution containingsodium, potassium, calcium, and magnesium ions and procainium chloride. The results of ITPmeasurements were compared with the results obtained by means of the standard pharmacopoeialmethods and in the case of alkalis also with the results of AAS. Precision, correctness, linearity,robustness, and selectivity of the ITP were evaluated.
Evaluation of the Quality of Mexiletine Hydrochloride by Means of CapillaryElectrophoresis
B. Proksa, A. Proksová
Čes. slov. farm. 2000, 49(4):195-198
Mexiletine hydrochloride and its potential impurity xylenol were determined by micelar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters - temperature, electricfield, concentration of analyzed compounds, type and composition of background electrolyte - on theseparation of analytes and precision of analysis was studied. The advantage of the elaboratedmethod is a very short time of analysis (2.3 min) at the sufficient level of precision and reliabilityof results.
Oxidative Determination of Hydroxyamphetamine in Drops by the Method of FlowInjection Analysis
J. Dolejšová, R. Karlíček, M. Pospíšilová
Čes. slov. farm. 2000, 49(4):199-200
A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (Ce IV) as the oxidation reagent. Under optimised conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78 % for 0.05 mmol.l-1 (n=10) and a sample through put of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.
Anti-Inflammatory Activities of Copper(II) and Zinc(II) p-Cresotates Dihydrates
J. Sokolík, I. Tumová, M. Bláhová, M. Daňková, P. Švec
Čes. slov. farm. 2000, 49(4):204-206
Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities of dihydrate of diaquatetrakis(p-cresotato)dicopper(II) complex (CupC) and diaquabis(p-cresotato)zinc(II) complex (ZnpC) were assayed plethysmometrically. Dihydrate of diaquabis(salicyla-to)copper(II) complex (CuS) and diaquabis(salicylato)zinc(II) complex (ZnS) were used as standards of comparison. All compounds were applied i.p. in a single dose of 50 mmol/kg body weight (calculatedfor the RCOO-fragment) 30 min before injecting the irritant. The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction) were found: CupC 46/74...