Čes. slov. farm. 2000, 49(4):204-206

Anti-Inflammatory Activities of Copper(II) and Zinc(II) p-Cresotates Dihydrates

J. Sokolík, I. Tumová, M. Bláhová, M. Daňková, P. Švec

Katedra chemickej teórie liečiv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava

Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities of dihydrate of diaquatetrakis(p-cresotato)dicopper(II) complex (CupC) and diaquabis(p-cresotato)zinc(II) complex (ZnpC) were assayed plethysmometrically. Dihydrate of diaquabis(salicyla-to)copper(II) complex (CuS) and diaquabis(salicylato)zinc(II) complex (ZnS) were used as standards of comparison. All compounds were applied i.p. in a single dose of 50 mmol/kg body weight (calculatedfor the RCOO-fragment) 30 min before injecting the irritant. The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction) were found: CupC 46/74 % - ZnpC50/26 % - CuS 71/52 % - ZnS 63/10 %. The relationships between the coordination-chemicalproperties and the biological effects of the corresponding complexes are discussed.

Keywords: copper(II) and zinc(II)p-cresotates; rat paw dextran-induced andcarrageenan-induced edemas; anti-inflammatory activity

Published: April 1, 2000  Show citation