Czech and Slovak Pharmacy, 2000 (vol. 49), issue 1
Articles
Nomenclature of Dosage Forms. An Outline of Its Development and Contemporary State
A. Libický, V. Mareš
Čes. slov. farm. 2000, 49(1):7-12
If the names used for dosage forms in pharmacopoeias and professional literature are examined,changes are found which are not always connected with extended knowledge about preparations,or the development of new variants of the dosage form. The same finding holds true for theirclassification into systematic groups. The problem has become particularly topical within theframework of international co-operation. The objective of the present paper is to inform about thesteps aiming at standardisation of their nomenclature at least in Europe.
On the Problems of Good Pharmacotherapy
J. Kolář, S. Szücsová
Čes. slov. farm. 2000, 49(1):13-20
The developments in the pharmaceutical profession have been changing the importance and share of the individual professional activities in it. The work with the pieces of information and with the patient, and advisory and consulting activities, which take place in monitoring pharmacotherapy, have become dominant. In this connection the paper elucidates the individual attributes of the concept of good drug therapy, the concept of good prescribing, various forms of the attitudes and behaviour of the patient in relationship to therapy, and the problems of medication errors.
Human Hepatocyte II. - Cryopreservation
Z. Dvořák, J. Adler, J. Ulrichová
Čes. slov. farm. 2000, 49(1):21-25
Human hepatocytes (HH) are an optimal in vitro model for the study of xenobiotics metabolism andtoxicity. However, there is still a problem of HH availability. A promising possibility for the storageof HH for later utilization is cryopreservation. Procedures and conditions used for cryopreservationof human hepatocytes and hepatocytes of other species are presented in the present paper. Comparedare some biochemical parameters characterizing viability and functionality of fresh and thawed HH.
Some Aspects of the Occurrence and Use of Anthracenons
J. Stano, K. Neubert, D. Grančai, E. Sedlárová, J. Kresánek
Čes. slov. farm. 2000, 49(1):26-28
The present paper aims to inform the pharmaceutical public about anthracenons and their naturalproducers. The first available mention dates from 1888 and the present authors also describe theirsynthesis and use in clinical practice.
Sterols in Lilium candidum L.
P. Mučaji, M. Haladová, E. Eisenreichová, M. Buděšínský, K. Ubik
Čes. slov. farm. 2000, 49(1):29-31
From the butanolic extract of petals of Lilium candidum L., b-sitosterol and b-sitosterol glucosidewere isolated. The isolated compounds were identified by spectroscopic means and by comparisonwith literature data; b-sitosterol glucoside was isolated in genus Lilium L. for the first time.
Antibacterial and Anticancer Activity of 2,4-Disubstituted 6H-5,1,3-Benzothiadiazocines
S. Jantová, M. Hazuchová, Š. Stankovský, K. Špirková
Čes. slov. farm. 2000, 49(1):32-36
Nine 2,4-disubstituted 6H-5,1,3-benzothiadiazocines have been tested for antibacterial and cytoto-xic efficacy. None of the tested compounds showed any significant antibacterial activity in compa-rison with ampicillin. The most cytotoxic effect was manifested by those derivatives which havemorpholine or phenyl in position 2 and benzimidazole, imidazole or 1,2,4-triazole in position 4. Thehighest concentrations of derivatives I, VII, IX induced an acute cytotoxic effect which wasmanifested by cell lysis after 24 h of culturing. Derivative VII, concentration 30.5 mmol/L, andderivative IX, concentration 13.3 mmol/L, exhibited a delayed cytotoxic effect...
Effect of Panpal Prophylaxis on the Activity of Acetylcholinesterase in the Blood, Diaphragm, and Various Parts of the Rat Brain in the Course of Untreated and Treated Intoxication with the Organophosphorous Insecticide Phosdrine
J. Kassa
Čes. slov. farm. 2000, 49(1):37-40
In experiments on male rats the paper investigated the effect of pharmacological prophylaxis withPanpal (pyridostigmine in combination with benactyzine and trihexyphenidyl) on the activity ofacetylcholinesterase in the whole blood, diaphragm, and selected parts of the brain (frontal cortex,pontomedular region, hippocampus, cerebellum) at hour 1 and 3 of untreated and treated (oximeHI-6 with atropine) intoxication with the organophosphorous insecticide phosdrine. Whereas in theCNS Panpal did not produce statistically significant changes in the activity of acetylcholinesterasein the course of untreated and treated phosdrine intoxication, in the blood...
Pharmacodynamic Parameters of Gentamicin and their Influence on Surface Hyd-rophobicity of Acinetobacter baumannii
A. Hoštacká
Čes. slov. farm. 2000, 49(1):41-44
The postantibiotic effect (PAE) and postantibiotic effect of subinhibitory concentration (PA SME) ofgentamicin as well as influence of these pharmacodynamic parameters on surface hydrophobicityof three Acinetobacter baumannii strains were studied in vitro. Suppression of bacterial growth (PAE) after a short time exposure of bacteria to gentamicin (30 min) at suprainhibitory concentration 2x MIC was in the range of 0.6 h to 3.4 h. Longer PAE was observed after treatment of bacteria with gentamicin at 4x MIC (1.5 h - 5.1 h). Supra-subinhibitory concentrations of gentamicin (2x or4x MIC + 0.2x MIC) caused still more effective delay of bacterial regrowth...
Effect of Compounds of Aryloxyaminopropanol Type on the Photosynthetic Activity ofSpinach Chloroplasts
R. Čižmáriková, K. Kráľová, F. Šeršeň
Čes. slov. farm. 2000, 49(1):45-47
The effect of 18 compounds of the aryloxyaminopropanol type - potencial beta-adrenolytics (differingeach from other by modifications in the hydrophilic and lipophilic part of the molecule) on the inhibition of oxygen evolution rate in spinach chloroplasts has been investigated. The compounds with n-octyloxymethyl and n-nonyloxymethyl group in position 3 of aromatic ring were found to exhibit the highest inhibitory activity (IC50 = 67, resp. 120 mmol dm-3). The compounds containing a heterocycle or the dimethylamino group in the hydrophilic part of the molecule and with propoxymethyl group on the aromatic ring were not active. Using EPR spectroscopy...