JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2024, 73(1):16-20 | DOI: 10.36290/csf.2024.003

Pharmacological profile of erdosteine - known molecule - new effects

Hana Kotolová1, Martina Nováková1, 2
1 Ústav farmakologie a toxikologie, Farmaceutická fakulta, Masarykova univerzita Brno
2 Ústav aplikované farmacie, Farmaceutická fakulta, Masarykova univerzita Brno

Erdostein belongs to the well-known thiol mucoactive drugs, whose effect is used in respiratory infections. Recently, expert findings show that the effect of erdosteine is more complex and can significantly contribute to the management of respiratory infections. Its antioxidant and anti-inflammatory properties come to the fore, or antiviral properties associated with them, as well as the ability to reduce bacterial adhesion and increase the effects of some antibiotics. Erdostein represents a comprehensive therapeutic option both in the field of self-treatment of respiratory infections and in other respiratory diseases.

Keywords: erdostein, mucomodulation, respiratory disease.

Accepted: March 19, 2024; Published: March 19, 2024  Show citation

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Kotolová H, Nováková M. Pharmacological profile of erdosteine - known molecule - new effects. Čes. slov. farm. 2024;73(1):16-20. doi: 10.36290/csf.2024.003.
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    References

    1. Kotolová H, Hammer T. Akutní respirační infekce - symptomatická samoléčba u dospělých, Prakt. lékáren. 2020;16(4):233-242 doi: 10.36290/lek.2020.037 Go to original source...
    2. Koblížek V, Sedlák V, Prachařová Š. Mukoaktivní medikace u infekčních a zánětlivých onemocnění dýchacích cest, Interní Med. 2009;11(12):539-543.
    3. Dal Negro R, Pozzi E, Cella SG. Erdosteine: Drug exhibiting polypharmacy for the treatment of respiratory diseases. Pulm Pharmacol Ther.2018;53:80-85. doi:10.1016/j.pupt.2018.10.005 Go to original source... Go to PubMed...
    4. Erdostein - SPC přípravku - SÚKL 02/2024.
    5. Procházková M, Doležal T. Erdosteinum, Remedia 2004,14(4):297-304.
    6. Dicpinigaitis PV, Morice AH, Birring SS, et al. Antitussive drugs--past, present, and future. Pharmacol Rev. 2014;66(2):468-512. Published 2014 Mar 26. doi:10.1124/pr.111.005116 Go to original source... Go to PubMed...
    7. Cazzola M, Page C, Rogliani P, Calzetta L, Matera MG. Multifaceted Beneficial Effects of Erdosteine: More than a Mucolytic Agent. Drugs. 2020 Nov;80(17):1799-1809. doi: 10.1007/s40265-020-01412-x. Go to original source... Go to PubMed...
    8. Cazzola M, Calzetta L, Page C, Rogliani P, Matera MG. Thiol-Based Drugs in Pulmonary Medicine: Much More than Mucolytics. Trends Pharmacol Sci. 2019;40(7):452-463. doi:10.1016/j.tips.2019.04.015 Go to original source... Go to PubMed...
    9. Braga PC, Dal Sasso M, Sala MT, Gianelle V. Effects of erdosteine and its metabolites on bacterial adhesiveness. Arzneimittelforschung. 1999;49(4):344-350. doi:10.1055/s-0031-1300425 Go to original source... Go to PubMed...
    10. Dal SM, Bovio C, Culici M, Braga PC. The combination of the SH metabolite of erdosteine (a mucoactive drug) and ciprofloxacin increases the inhibition of bacterial adhesiveness achieved by ciprofloxacin alone. Drugs Exp Clin Res. 2002;28(2-3):75-82.
    11. Braga PC, Zuccotti T, Dal Sasso M. Bacterial adhesiveness: effects of the SH metabolite of erdosteine (mucoactive drug) plus clarithromycin versus clarithromycin alone. Chemotherapy. 2001;47(3):208-214. doi:10.1159/000063223 Go to original source... Go to PubMed...
    12. Pinto Rita M, Soares Filipa A, Reis Salette, et al. Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms Frontiers in Microbiology vOl. 11 2020 doi:10.3389/fmicb.2020.00952 Go to original source... Go to PubMed...
    13. Pani A, Lucini V, Dugnani S, Scaglione F. Erdosteine enhances antibiotic activity against bacteria within biofilm. Int J Antimicrob Agents. 2022;59(3):106529. doi:10.1016/j.ijantimicag.2022.106529 Go to original source... Go to PubMed...
    14. Maurizio Moretti, Carlo Felice Marchioni: An overview of erdosteine antioxidant activity in experimental research, Pharmacological Research, 2007;55(4):249-54. https://doi.org/10.1016/j.phrs.2006.12.006. Go to original source... Go to PubMed...
    15. Cazzola M, Rogliani P, Calzetta L, Hanania NA, Matera MG. Impact of Mucolytic Agents on COPD Exacerbations: A Pair-wise and Network Meta-analysis. COPD. 2017;14(5):552-563. doi:10.1080/15412555.2017.1347918 Go to original source... Go to PubMed...
    16. Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 Jul 10;6(7):1558-1562. Go to original source... Go to PubMed...
    17. Kotolová H. Symptomatická léčba chřipky, nachlazení a COVID-19, Doporučený postup, ČLK, 2021
    18. Skalny AV, Rink L, Ajsuvakova OP, et al. Zinc and respiratory tract infections: Perspectives for COVID19 (Review). Int J Mol Med. 2020;46(1):17-26. doi:10.3892/ijmm.2020.4575 Go to original source... Go to PubMed...
    19. Strizzi S, Danzo F, Vanetti C, et al. Erdosteine and its metabolite Met-1 modulate innate immunity and stress oxidative state in SARS-CoV-2 infection. e-poster, ID3854. ERS International Congress, Milano, 2023 Sep 9-13. Go to original source...
    20. Santus P, Tursi F, Croce G, et al. Changes in quality of life and dyspnoea after hospitalization in COVID-19 patients discharged at home. Multidis Res Med 2020; 15:713. Go to original source... Go to PubMed...
    21. Feshchenko YI, Ostrovskyy MM, Varunkiv OI, Horovenko NH. Improved quality of life and dyspnea with erdosteine in COVID-19 patients after hospital discharge. Minerva Respir Med 2022;61:54-62. doi: 10.23736/S2784-8477.22.01992-1 Go to original source...
    22. Dal Negro RW, Wedzicha JA, Iversen M, et al, RESTORE group. Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study. Eur Respir J 2017;50(4): 1700711, doi: 10.1183/13993003.00711-2017. Go to original source... Go to PubMed...
    23. Kopřiva F, Látalová V. Improving the Primary Care Management of Preschool Children with Recurrent Acute Respiratory Tract Infections in the Czech Republic: Prompt Use of Erdosteine Can Reduce Antibiotic Prescribing. Quality in Primary Care. 2019;27(4):36-42.
    24. Calverley PMA, Papi A, Page C, et al. The effect of maintenance treatment with erdosteine on exacerbation treatment and health status in patients with COPD: a post-hoc analysis of the RESTORE dataset. Int J Chron Obstruct Pulmon Dis. 2022;17:1909-1920, doi: 10.2147/COPD.S369804. Go to original source... Go to PubMed...

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