JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2023, 72(6):296-302 | DOI: 10.5817/CSF2023-6-296

Increasing the efficiency of hypolipidemic therapy with the combined use of quercetin in patients with non-alcoholic fatty liver disease on the background of the metabolic syndrome

Lyudmila Kravchenko, Liana Unhurian*, Svetlana Kotiuzhinska, Yana Ivanova, Maya Obrazenko, Liudmyla Zahorodnya, Tetiana Yamilova
Odessa National Medical University, Odesa, Department of Organization and Economics of Pharmacy, Faculty of Pharmacy, Odessa, Ukraine

The article analyzes the results of a set of biochemical indicators in the course of treatment with the combined use of rosuvastatin with quercetin in patients with metabolic syndrome (MS) combined with non-alcoholic fatty liver disease.
Changes in blood biochemical parameters have been identified and presented with MS, essential for revealing generalbiological mechanisms development and interrelationship between the components of MS and non-alcoholic fatty liver. The effect of an increase in free cholesterol and triglycerides and activation of freeradical oxidation of lipids followed by theaccumulation of oxidative stress products was noted.
In the course of long-term hypolipidemic therapy (90 days), 86 patients with non-alcoholic fatty liver disease on the background of metabolic syndrome were previously divided into 2 groups: a comparison group (45 patients), who weretreated with basic therapy - only rosuvastatin, the main group (41 patients) received quercetin together with rosuvastatin - 40 mg 3 times a day, clinical and laboratory-instrumental examinations were carried out.
On the 90th day of treatment, positive results in the functional state of the liver and lipid spectrum of the blood wereregistered in all patients. A more significant advantage of the therapeutic combination of rosuvastatin with quercetin was proved. The inclusion of quercetin contributed to reducing the intensity of oxidative stress and enhancing antioxidant protection activity, resultingin a decrease in apoptosis of hepatocytes (cytokeratin-18 level was 1.27 times decreased). The studies have shown the feasibility of combined use of quercetin with rosuvastatin for the prevention of the development and progression of metabolic disorders associated with non-alcoholic fatty liver disease.

Keywords: metabolic syndrome; oxidative stress; non-alcoholic fatty liver disease; quercetin; apoptosis of hepatocytes

Received: October 4, 2023; Accepted: November 12, 2023; Published: June 1, 2023  Show citation

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Kravchenko L, Unhurian L, Kotiuzhinska S, Ivanova Y, Obrazenko M, Zahorodnya L, Yamilova T. Increasing the efficiency of hypolipidemic therapy with the combined use of quercetin in patients with non-alcoholic fatty liver disease on the background of the metabolic syndrome. Čes. slov. farm. 2023;72(6):296-302. doi: 10.5817/CSF2023-6-296.
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