Čes. slov. farm. 2023, 72(4):184-189 | DOI: 10.5817/CSF2023-4-184

Study of the anti-inflammatory properties of a thick extract of Tribulus terrestris L.

Saida Yunusova^*, Yaroslav Rozhkovskyi, Bohdan Prystupa, Svitlana Bohatu

Department of Pharmacology and Pharmacognosy, Odesa National Medical University, Odessa, Ukraine

The most promising direction in the treatment of chronic prostatitis is the use of medicinal plants and preparations based on them, which contain natural compounds with a broad spectrum of pharmacological activity: anti-inflammatory, antimicrobial, reparative, immunomodulatory, hormone-regulating, antisclerotic, etc., and which can provide a complex therapeutic effect on the course of chronic prostatitis. A promising raw material in this direction is Tribulus terrestris L., a herbal preparation traditionally used to treat erectile dysfunction and atherosclerosis. This experimental work aims to study the anti-inflammatory activity of a thick extract of the Tribulus terrestris grass (freed from fruits) on the models of carrageenan and zymosan inflammation in rats.
In the models of carrageenan and zymosan edema in rats, a thick extract of Tribulus terrestris L. in doses from 50 mg/kg to 200 mg/kg shows anti-inflammatory activity, the efficacy of which in the dose range of 150-200 mg/g in the initial stages of carrageenan inflammation is not inferior to sodium diclofenac at a dose of 8.0 mg/kg, and in the initial stages of zymosan inflammation, respectively, before the reference drug corvitin at a dose of 10 mg/kg. It indicates the anticyclogenase and antilipoxygenase properties of this thick extract.

Keywords: diclofenac sodium; thick extract; Tribulus terrestris; corvitin; anti-inflammatory effect

Received: February 26, 2023; Accepted: June 1, 2023; Published: April 1, 2023  Show citation