JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2022, 71(3):98-102 | DOI: 10.5817/CSF2022-3-98

The effect of Aronia melanocarpa extract on the phospholipid composition of the rat myocardium during stress

Volodymyr Shvets1,*, Hanna Maslak2, Vadim Davydov3, Halyna Berest4, Inna Nosulenko5
1 Zaporizhzhya State Medical University, Department of Biochemistry, Zaporizhzhya, Ukraine
2 Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine, Department of Biochemistry and Medical Chemistry, Dnieper, Ukraine
3 Pirogov Russian National Research Medical University, Department of Biochemistry and Molecular Biology, Moscow, Russia
4 Zaporizhzhya State Medical University, Department of Management and Economics of Pharmacy and Drug Technology, Zaporizhzhya, Ukraine
5 Zaporizhzhya State Medical University, Department of Pharmacognosy, Pharmacology, and Botany, Zaporizhzhya, Ukraine

The research was performed on 80 male rats of the Wistar line. Animals of two age groups were used: adults (10-12 months) and old (22-25 months). The obtained data show that the development of immobilization stress in adult and aged rats are accompanied by the formation of a characteristic complex of changes in the phospholipid composition of the myocardium. Intraperitoneal injection of the chokeberry extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited stress modulation of myocardial phospholipid composition in aged animals. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

Keywords: Myocardium; aging; immobilization; Aronia melanocarpa

Received: November 3, 2021; Accepted: April 27, 2022; Published: March 1, 2022  Show citation

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Shvets V, Maslak H, Davydov V, Berest H, Nosulenko I. The effect of Aronia melanocarpa extract on the phospholipid composition of the rat myocardium during stress. Čes. slov. farm. 2022;71(3):98-102. doi: 10.5817/CSF2022-3-98.
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