JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2019, 68(2):69-77 | DOI: 10.36290/csf.2019.009

Influence of formulation and process parameters on the properties of Cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis

Miroslava Pavelková1, Jakub Vysloužil1,*, Kateřina Kubová1, Sylvie Pavloková1, Eliška Mašková1,2, David Vetchý1
1 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
2 Department of Pharmacology and Immunotherapy, Veterinary Research Institute

Currently, the method of external ionic gelation for the preparation of alginate particles is successfully used not only in the field of pharmacy and medicine, but also especially in the field of biotechnology. Therefore, the preparation of alginate particles and their subsequent evaluation using principal component analysis was the key task of our experiment. To optimize this method, we focused on the evaluation of the effect of formulation (the polymer concentration, the hardening solution concentration) and process parameters (the outer diameter of the injection needle) on the properties of the resulting beads (yield, sphericity factor, equivalent diameter and swelling capacity at pH 6). Using multivariate data analysis, the major influence on the resulting properties of the prepared particles was confirmed only in sodium alginate concentration. Obtained results verified the reliable and safe potential of the external ionic gelation for preparation alginate-based particulate dosage forms.

Keywords: hydrogel particles; external ionic gelation; sodium alginate; copper ions; evaluation of the particulate dosage form; Principal component analysis
Grants and funding:

This work was supported by the Ministry of Education, Youth and Sports project "FIT" (Pharmacology, Immunotherapy, nanoToxicology) CZ.02.1.01/0.0/0.0/15 003/0000495 and by the Ministry of Agriculture of the Czech Republic, institutional support MZE-R00518.

Received: March 18, 2019; Accepted: March 29, 2019; Published: February 1, 2019  Show citation

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Pavelková M, Vysloužil J, Kubová K, Pavloková S, Mašková E, Vetchý D. Influence of formulation and process parameters on the properties of Cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis. Čes. slov. farm. 2019;68(2):69-77. doi: 10.36290/csf.2019.009.
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