JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2017, 66(6):267-273 | DOI: 10.36290/csf.2017.038

Gut microbiota: its development and relation to certain diseases

Hana Kiňová Sepová*, Boris Dudík, Andrea Bilková
Katedra bunkovej a molekulárnej biológie liečiv, Farmaceutická fakulta, Univerzita Komenského v Bratislave

Coexistence of humans with microorganisms is well known for a long time. Besides the association with infectious diseases, personal microbiota is important for human health, possibly for some non-infectious diseases. Colonization of the human body with appropriate microorganisms after delivery is essential for physiological immune system maturation and also has an influence on central nervous system development. The composition of the gut microbiota is affected by the mode of delivery, early life nutrition and last but not least by lifestyle and drug, especially antibiotics intake. A comparison of gut microbiomes between individuals living in different parts of the world showed a cardinal variation in its composition and basic enterotypes were defined. Interestingly, it has been found out that the different microbiota species' composition covers the same, respectively similar metabolic pathways. It is suggested that gut microbiota composition and its dysbiosis may influence civilization diseases development, e. g. diabetes mellitus, obesity, asthma, inflammatory bowel disease, allergy, and autoimmune diseases.

Keywords: gut microbiota; microbiome; health; immune system; dysbiosis

Received: November 9, 2017; Accepted: November 27, 2017; Published: June 1, 2017  Show citation

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Kiňová Sepová H, Dudík B, Bilková A. Gut microbiota: its development and relation to certain diseases. Čes. slov. farm. 2017;66(6):267-273. doi: 10.36290/csf.2017.038.
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