JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2017, 66(3):117-126 | DOI: 10.36290/csf.2017.019

Effect of the vaginal pessaries Melanizol® and Klimedeks® on the glycogen level in the vaginal tissue of rats on the background of experimental vaginitis

Olena V. Dolzhykova1,*, Ludmyla M. Maloshtan1, Rimma F. Yeriomenko1, Volodymyr A. Maloshtan2
1 Department of Physiology and Human Anatomy, National University of Pharmacy (NUPh), Kharkiv, Ukraine
2 Department of Anaesthesiology and Intensive Care of the Kharkiv Medical Academy of Postgraduate Education

The experimental studies of the new vaginal pessaries Melanizol® and Klimedeks® have been carried out on the model of experimental vaginitis induced in rats by a mixture of terebenthine oil and dimethyl sulfoxide. The obtained experimental data indicate that the vaginal pessaries Melanizol® and Klimedeks® on the background of experimental vaginitis have a therapeutic effect on the 5th and 8th days of the experiment, significantly surpassing the group of animals of control pathology and placebo in its ability to restore physiological functions and accumulate glycogen by the vaginal epithelium. Melanizol® and Klimedeks® have significantly surpassed the reference drugs, the pessaries Gravagin® and Hippophaes oleum, but have been less efficient in the activity to the reference drug, the vaginal tablets Micogynax® on this criterion.

Keywords: glycogen; vaginal pessaries; vaginitis; rats

Received: March 17, 2017; Accepted: May 12, 2017; Published: March 1, 2017  Show citation

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Dolzhykova OV, Maloshtan LM, Yeriomenko RF, Maloshtan VA. Effect of the vaginal pessaries Melanizol® and Klimedeks® on the glycogen level in the vaginal tissue of rats on the background of experimental vaginitis. Čes. slov. farm. 2017;66(3):117-126. doi: 10.36290/csf.2017.019.
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