JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2016, 65(4):139-160 | DOI: 10.36290/csf.2016.030

Use of plant extracts as an efficient alternative therapy of respiratory tract infections

Karel Šmejkal*, Veronika Rjašková
University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Department of Natural Drugs, Brno, Czech Republic

Medicinal plants are advantageously used in the treatment of respiratory tract diseases. Upper respiratory tract catarrh is one of the diseases associated with seasonal weakening of immunity, and therefore, plant drugs with a non-specific immunomodulation effect are often used. Such plants include, but are not limited to, Echinacea (Echinacea purpurea) and American ginseng (Panax quinquefolius). In combination with medicinal plants having antibacterial and antiseptic effects, such as thyme (Thymus vulgaris) and pelargonium (Pelargonium sidoides), they can constitute efficient help in the treatment of respiratory tract diseases, shorten the duration of the disease and reduce the need of antibiotic therapy. The text presented summarizes the basic information about these plants, their ingredients, mechanisms of action and clinical tests confirming their effect and monitoring eventual adverse effects.

Keywords: Echinacea purpurea; Panax quinquefolius; Pelargonium sidoides; Thymus vulgaris; upper respiratory tract catarrh; immunity
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Extracts of ginseng (P. quinquefolium) and purple coneflower (Echinacea spp.) stimulate the immune system and improve resistance of the organism to infection agents causing upper respiratory tract catarrh. Their action can be supported by extracts of thyme (T. vulgaris) or umckaloabo geranium (P. sidoides), which have a major antibacterial influence and can contribute to already running disease. In terms of phytochemistry, these medicinal plants have been explored relatively well and the mechanism of their action has been described in a number of both in vitro and in vivo studies.

Received: August 1, 2016; Accepted: August 12, 2016; Published: April 1, 2016  Show citation

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Šmejkal K, Rjašková V. Use of plant extracts as an efficient alternative therapy of respiratory tract infections. Čes. slov. farm. 2016;65(4):139-160. doi: 10.36290/csf.2016.030.
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    References

    1. Kopřiva F. Diagnostika a léčba bronchitídy u dětí. Pediatr. pro Praxi 2007; 2, 106-108.
    2. Pauk N. Terapie akutní bronchitídy. Interní Med. 2011; 13, 327-328.
    3. Tan B. K., Vanitha J. Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: a review. Curr. Med. Chem. 2004; 11, 1423-30. Go to original source... Go to PubMed...
    4. Das S., Bordoloi R., Newar N. A review on immune modulatory effect of some traditional medicinal herbs. J. Pharm. Chem. Biol. Sci. 2014; 2, 33-42.
    5. Cundell D. R. Herbal Phytochemicals as Immunomodulators. Curr. Immunol. Rev. 2014; 10, 64-81. Go to original source...
    6. Shukla S., Bajpai V. K., Kim M. Plants as potential sources of natural immunomodulators. Rev. Environ. Sci. Bio. 2014; 13, 17-33. Go to original source...
    7. Manayi A., Vazirian M., Saeidnia S. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacogn. Rev. 2015; 9, 63-72. Go to original source... Go to PubMed...
    8. Gupta M., Sharma D., Sharma A., Kumari V., Goshain O. P. A review on purple cone flower (Echinacea purpurea L. Moench. J. Pharm. Res. 2012; 8, 4076-4081.
    9. Community herbal monograph on Echinacea purpurea (L. Moench, radix) EMA/HMPC/577784/2008. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2011/01/WC500101497.pdf
    10. Community herbal monograph on Echinacea angustifolia DC., radix. EMA/HMPC/688216/2008. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2012/05/WC500127890.pdf
    11. Community herbal monograph on Echinacea pallida (Nutt. Nutt., radix) EMEA/HMPC/332350/2008. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2009/12/WC500018248.pdf
    12. European Union herbal monograph on Echinacea purpurea (L. Moench, herba recens) EMA/HMPC/48704/2014. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2015/04/WC500185437.pdf
    13. Gajalakshmi S., Vijayalakshmi S., Devirajeswari V. Echinaceae puprpurea - a potent immunostimulant. Int. J. Pharm. Sci. Rev. Res. 2012; 14, 47-52.
    14. Barnes J., Anderson L. A., Gibbons S., Phillipson J. D. Echinacea species (Echinacea angustifolia (DC. Hell.) Echinacea pallida (Nutt.) Echinacea purpurea (L.) Moench. a review of their chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 2005; 57, 929-954. Go to original source... Go to PubMed...
    15. Woelkart K., Dittrich P., Beubler E., Pinl F., Schoop R., Suter A., Bauer R. Pharmacokinetics of the main alkamides after administration of three different Echinacea purpurea preparations in humans. Planta Med. 2008; 74, 651-656. Go to original source... Go to PubMed...
    16. Shekarchi M., Hajimehdipoor H., Khanavi M., Roostaie A. The effects of plant age and harvesting time on chicoric and caftaric acids content of E. purpurea (L. Moench). Iranian J. Pharm. Sci. 2012; 8, 203-208.
    17. Thomsen M. O., Frette X. C., Christensen K, B., Christensen L. P., Grevsen K. Seasonal Variations in the Concentrations of Lipophilic Compounds and Phenolic Acids in the Roots of Echinacea purpurea and Echinacea pallida. J. Agric. Food Chem. 2012; 60, 12131-12141. Go to original source... Go to PubMed...
    18. Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine 2003; 10, 66-86. Go to original source... Go to PubMed...
    19. Rininger J. A., Kickner S., Chigurupati P., McLean A., Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J. Leukocyte Biol. 2000; 68, 503-510. Go to original source...
    20. Eichler F., Krüger G. R. F. Effects of non-specific immunostimulants (Echinacin, isoprinosine, and thymus factors. on the infection and antigen expression in herpesvirus-6 exposed human lymphoid cells. In Vivo 1994; 8, 565-576.
    21. Bauer R., Remiger P., Jurcic K., Wagner H. Beeinflussung der Phagozytose-Aktivität durch Echinacea-Extrakte. Influence of Echinacea extract on phagocytotic activity. Z. Phytother. 1989; 10, 43-48.
    22. Bauer R., Wagner H. Echinacea species as potential immunostimulatory drugs. In: Wagner H., Farnsworth N. R. (eds.) Economic and Medicinal Plant Research. New York: Academic Press Limited 1991; 253-318.
    23. Bauer R. Chemistry, analysis and immunological investigations of Echinacea phytopharmaceuticals. In: Wagner H. (ed.) Immunomodulatory Agents from Plants. Basel, Boston, Berlin: Birkhauser Verlag 1999; 41-88. Go to original source...
    24. Woelkart, K., Bauer, R. The role of alkamides as an active principle of echinacea. Planta Med. 2007; 73, 615-623. Go to original source... Go to PubMed...
    25. Woelkart K., Xu W., Pei Y., Makriyannis A., Picone R. P., Bauer R. The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. Planta Med. 2005; 71, 701-705. Go to original source... Go to PubMed...
    26. Karsch-Völk M., Barrett B., Kiefer D., Bauer R., Ardjomand-Woelkart K., Linde K. Echinacea for preventing and treating the common cold. Cochrane Database Syst. Rev. 2014; 2, CD000530. Go to original source... Go to PubMed...
    27. Schapowal A., Klein P., Johnston S. L. Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials. Adv. Ther. 2015; 32, 187-200. Go to original source... Go to PubMed...
    28. Baetgen D. Erfolge in der Keuchhusten-Behandlung mit Echinacin®. Successful treatment of whooping cough with Echinacea. Therapiewoche 1984; 34, 5115-5119.
    29. Baetgen D. Behandlung der akuten Bronchitis im Kindesalter. Praxisstudie mit einem Immunstimulans aus Echinacea purpurea. Treatment of acute bronchitis in children. A study of an immunostimulatory agent from Echinacea purpurea in a primary care setting. Translator unknown. Therapiewoche Pädiatrie 1988; 1, 65-70.
    30. Melchart D., Linde K., Worku F., Bauer R., Wagner H. Immunomodulation with echinacea - a systematic review of controlled clinical trials. Phytomedicine 1994; 1, 245-254. Go to original source... Go to PubMed...
    31. Turner R. B., Riker D. K., Gangemi J. D. Ineffectiveness of Echinacea for prevention of experimental rhinovirus colds. Antimicrob. Agents Chemother. 2000; 44, 1708-1709. Go to original source... Go to PubMed...
    32. Melchart D., Walther E., Linde K., Brandmaier R., Lersch C. Echinacea root extracts for the prevention of upper respiratory tract infections: A double-blind, placebo-controlled randomized trial. Arch. Family Med. 1998; 7, 541-545. Go to original source... Go to PubMed...
    33. Schöneberger D. Einfluß der immunstimulierenden Wirkung von Preßsaft aus Echinacea purpurea auf Verlauf und Schweregrad von Erkältungskrankheiten. The influence of the immunostimulating effects of pressed juice from Echinacea purpurea on the course and severity of cold infections. Forum Immunologie 1992; 8, 18-22.
    34. Grimm W., Muller H. H. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on incidence and severity of colds and respiratory infections. Am. J. Med. 1999; 106, 138-143. Go to original source... Go to PubMed...
    35. Bräunig B., Dorn M., Knick E. Echinaceae purpureae radix: Zur Stärkung der körpereigenen Abwehr bei grippalen Infekten. Strengthening of the endogenous resistence to influenzal infections. Z. Phytother. 1992; 13, 7-13.
    36. Melchart D., Linde K. Clinical investigations of Echinacea phytopharmaceuticals. In: Wagner H. (ed.) Immunomodulatory Agents from Plants. Basel, Boston, Berlin: Birkhauser Verlag 1999; 105-118. Go to original source...
    37. Brinkeborn R. M., Shah D. V., Degenring F. H. Echinaforce® and other Echinacea fresh plant preparations in the treatment of the common cold. Phytomedicine 1999; 6, 1-6. Go to original source... Go to PubMed...
    38. Schmidt U., Albrecht M., Schenk N. Pflanzliches Immunstimulans senkt Haufigkeit grippaler Infekte. Natur- und Ganzheitsmedizin 1990; 3, 277-281.
    39. Cohen H. A., Varsano I., Kahan E., Sarrell E. M., Uziel Y. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Arch. Pediatr. Adolesc. Med. 2004; 158, 217-221. Go to original source... Go to PubMed...
    40. Taylor J. A., Weber W., Standish L., et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003; 290, 2824-2830. Go to original source... Go to PubMed...
    41. Jawad M., Schoop R., Suter A., Klein P., Eccles R. Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: a randomized, doubleblind, placebo-controlled trial. Evid Based Complement. Alternat. Med. 2012; 2012, 841315. Go to original source... Go to PubMed...
    42. Gallo M., Sarkar M., Au W., Pietrzak K., Comas B., Smith M, Jaeger T. V., Einarson A., Koren G. Pregnancy outcome following gestational exposure to Echinacea. Arch. Intern. Med. 2000; 160, 3141-3143. Go to original source... Go to PubMed...
    43. Qi L.-W., Wang C.-Z., Yuan C.-S. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 2011; 72, 689-699. Go to original source... Go to PubMed...
    44. Yuan C.-S., Wang C.-Z., Wicks S. M., Qi L.-W. Chemical and pharmacological studies of saponins with a focus on American ginseng. J. Ginseng Res. 2010; 34, 160-167. Go to original source... Go to PubMed...
    45. Do J. H., Lee H. O., Lee S. K., Noh K. B., Lee S. D., Lee K. S. Comparisons of acidic polysaccharide content in various ginseng species and parts. J. Ginseng Res. 1993; 17, 145-147.
    46. Liao J.-F., Shen Y.-C., Huang Y.-T. Pharmacology of Polysaccharides from Ginseng Species. Int. J. Biomed. Pharm. Sci. 2012; 6, 63-69.
    47. Han B. H., Park M. H., Han Y. N., Woo L. K., Sankawa U., Yahara S., Tanaka O. Degradation of ginseng saponins under mild acidic conditions. Planta Med. 1982; 44: 146-149. Go to original source... Go to PubMed...
    48. Karikura M., Miyase T., Tanizawa H., Taniyama T., Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. Chem. Pharm. Bull. 1991; 39, 400-404. Go to original source... Go to PubMed...
    49. Karikura M., Miyase T., Tanizawa H., Taniyama T., Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chem. Pharm. Bull. 1991; 39, 2357-2361. Go to original source... Go to PubMed...
    50. Hasegawa H., Sung J. H., Matsumiya S., Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1996; 62, 453-457. Go to original source... Go to PubMed...
    51. Wakabayashi C., Murakami K., Hasegawa H., Murata J., Saiki I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 1998; 246, 725-730. Go to original source... Go to PubMed...
    52. Suda K., Murakami K., Murata J., Hasegawa H., Saiki I. Induction of apoptosis in Lewis lung carcinoma cells by an intestinal bacterial metabolite resulted from orally administered ginseng protopanaxadiol saponins. J. Trad. Med. 2000; 17, 236-244.
    53. Hasegawa H., Suzuki R., Nagaoka T., Tezuka Y., Kadota S., Saiki I. Prevention of growth and metastasis of murine melanoma through enhanced natural killer cytotoxicity by fatty acid conjugate of protopanxatriol. Biol. Pharm. Bull. 2002; 25, 861-866. Go to original source... Go to PubMed...
    54. Hasegawa H., Lee K. S., Nagaoka T., Tezuka Y., Uchiyama M., Kadota S., Saiki I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid ester. Biol. Pharm. Bull. 2000; 23, 298-304. Go to original source... Go to PubMed...
    55. Sievenpiper J. L., Arnason J. T., Leiter L. A., Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J. Am. Coll. Nutr. 2004; 23, 248-258. Go to original source... Go to PubMed...
    56. Dascalu A., Sievenpiper J. L., Jenkins A. L., Stavro M. P., Leiter L. A., Arnason T., Vuksan V. Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals. Can. J. Physiol. Pharmacol. 2007; 85, 856-864. Go to original source... Go to PubMed...
    57. Kang S., Min H. Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System. J. Ginseng Res. 2012; 36, 354-368. Go to original source... Go to PubMed...
    58. Rivera E., Ekholm Pettersson F., Inganäs M., Paulie S., Grönvik K. O. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 2005; 23, 5411-5419. Go to original source... Go to PubMed...
    59. Yang Z., Chen A., Sun H., Ye Y., Fang W. Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice. Vaccine 2007; 25, 161-169. Go to original source... Go to PubMed...
    60. Sun J., Song X., Hu S. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin. Vaccine Immunol. 2008; 15, 303-307. Go to original source... Go to PubMed...
    61. Song X., Chen J., Sakwiwatkul K., Li R., Hu S. Enhancement of immune responses to influenza vaccine (H3N2). by ginsenoside Re. Int. Immunopharmacol. 2010; 10, 351-356. Go to original source... Go to PubMed...
    62. Song X., Hu S. Adjuvant activities of saponins from traditional Chinese medicinal herbs. Vaccine 2009; 27, 4883-4890. Go to original source... Go to PubMed...
    63. Lee E. J., Ko E., Lee J., Rho S., Ko S., Shin M. K., Min B. I., Hong M. C., Kim S., Y., Bae H. Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation. Int. Immunopharmacol. 2004; 4, 235-244. Go to original source... Go to PubMed...
    64. Lee J. H., Han Y. Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell. Int. Immunopharmacol. 2006; 6, 1424-1430. Go to original source... Go to PubMed...
    65. Kenarova B., Neychev H., Hadjiivanova C., Petkov V. D. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn. J. Pharmacol. 1990; 54, 447-454. Go to original source... Go to PubMed...
    66. Song X., Zang L., Hu S. Amplified immune response by ginsenoside-based nanoparticles (ginsomes.. Vaccine 2009; 27, 2506-2511. Go to original source... Go to PubMed...
    67. Tung N. H., Quang T. H., Son J. H., Koo J. E., Hong H. J., Koh Y. S., Song G. Y., Kim Y. H. Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells. Arch. Pharm. Res. 2011; 34, 681-685. Go to original source... Go to PubMed...
    68. Luo Y. M., Cheng X. J., Yuan W. X. Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats. Zhongguo Yao Li Xue Bao 1993; 14, 401-404.
    69. Su W., Sun A. J., Xu D. L., Zhang H. Q., Yang L., Yuan L. Y., Jia J. G., Zou Y. Z., Wu Y. L., Wang K. Q., Ge J. B. Inhibiting effects of total saponins of panax ginseng on immune maturation of dendritic cells induced by oxidized-low density lipoprotein. Cell Immunol. 2010; 263, 99-104. Go to original source... Go to PubMed...
    70. Joh E. H., Lee I. A., Jung I. H., Kim D. H. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation. Biochem. Pharmacol. 2011; 82, 278-286. Go to original source... Go to PubMed...
    71. Byeon S. E., Lee J., Kim J. H., Yang W. S., Kwak Y. S., Kim S. Y., Choung E. S., Rhee M. H., Cho J. Y. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediat. Inflamm. 2012; 2012, ID 732860. Go to original source... Go to PubMed...
    72. Tomoda M., Hirabayashi K., Shimizu N., Gonda, R., Ohara, N. The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng. Biol. Pharm. Bull. 1994; 17, 1287-1291. Go to original source... Go to PubMed...
    73. Kim K. H., Lee Y. S., Jung I. S., Park S. Y., Chung H. Y., Lee I. R., Yun Y. S. Acidic polysaccharide from Panax ginseng, Ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with IL-2. Planta Med. 1998; 64, 110-115. Go to original source... Go to PubMed...
    74. Sonoda Y., Kasahara T., Mukaida N., Shimizu N., Tomoda M., Takeda T. Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology 1998; 38, 287-294. Go to original source... Go to PubMed...
    75. Assinewe V., Arnason J., Aubry A., Mullin J., Lemaire I. Extractable polysaccharides of Panax quinquefolius L. North American ginseng. root stimulate TNFα production by alveolar macrophages. Phytomedicine 2002; 9, 398-404. Go to original source... Go to PubMed...
    76. Jang H. I., Shin H. M. Wild Panax ginseng. Panax ginseng C. A. Meyer. protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Am. J. Chin. Med. 2010; 38, 949-960. Go to original source... Go to PubMed...
    77. Azike C. G., Charpentier P. A., Hou J., Pei H., King Lui E. M. The Yin and Yang actions of North American ginseng root in modulating the immune function of macrophages. Chin. Med. 2011; 6, 21. Go to original source... Go to PubMed...
    78. Ahn J. Y., Choi I. S., Shim J. Y., Yun E. K., Yun Y. S., Jeong G., Song J. Y. The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur. J. Immunol. 2006; 36, 37-45. Go to original source... Go to PubMed...
    79. Kim D. Y., Yang W. M. Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. J. Ethnopharmacol. 2011; 136, 230-235. Go to original source... Go to PubMed...
    80. Ro J. Y., Ahn Y. S., Kim K. H. Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions. Int. J. Immunopharmacol. 1998; 20, 625-41. Go to original source... Go to PubMed...
    81. Biondo P. D., Goruk S., Ruth M. R., O'Connell E., Field C. J. Effect of CVT-E002 (COLD-fX. versus a ginsenoside extract on systemic and gut-associated immune function. Int. Immunopharmacol. 2008; 8, 1134-1142. Go to original source... Go to PubMed...
    82. Lee J. H., Shim J. S., Chung M. S., Lim S. T., Kim K. H. Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng. Biosci. Biotechnol. Biochem. 2009; 73, 209-212. Go to original source... Go to PubMed...
    83. Lee J. H., Shim J. S., Lee J. S, Kim M. K., Chung M. S., Kim K. H. Pectin-like acidic polysaccharide from Panax ginseng with selective antiadhesive activity against pathogenic bacteria. Carbohydr. Res. 2006; 341, 1154-1163. Go to original source... Go to PubMed...
    84. Fukuyama N., Shibuya M., Orihara Y. Antimicrobial polyacetylenes from Panax ginseng hairy root culture. Chem. Pharm. Bull. 2012; 60, 377-380. Go to original source... Go to PubMed...
    85. Chan L. Y., Kwok H. H., Chan R. W., Peiris M. J., Mak N. K., Wong R. N., Chan M. C., Yue P. Y. Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J. Ethnopharmacol. 2011; 137, 1542-1546. Go to original source... Go to PubMed...
    86. Kim J. Y., Kim H. J., Kim H. J. Effect of oral administration of Korean red ginseng on influenza A (H1N1. virus infection. J. Ginseng. Res. 2011; 35, 104-110. Go to original source...
    87. Quan F. S., Compans R. W., Cho Y. K., Kang S. M. Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection. Vaccine 2007; 25, 272-282. Go to original source... Go to PubMed...
    88. Kim J., Han B. J., Kim H., Lee J. Y., Joo I., Omer S., Kim Y. S., Han Y. Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans. Int. Immunopharmacol. 2012; 14, 481-486. Go to original source... Go to PubMed...
    89. Song X., Zang L., Hu S. Amplified immune response by ginsenoside-based nanoparticles ginsomes. Vaccine 2009; 27, 2306-2311. Go to original source... Go to PubMed...
    90. Song X., Chen J., Sakwiwatkul K., Li R., Hu S. Enhancement of immune responses to influenza vaccine (H3N2. by ginsenoside Re. Int. Immunopharmacol. 2010; 10, 351-356. Go to original source... Go to PubMed...
    91. Scaglione F., Cattaneo G., Alessandria M., Cogo R. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold. Drugs Exp. Clin. Res. 1996; 22, 65-72.
    92. Sun K., Wang C. S., Guo J., Horie Y., Fang S. P., Wang F., et al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci. 2007; 81, 509-518. Go to original source... Go to PubMed...
    93. Park E. K., Shin Y. W., Lee H. U., Kim S. S., Lee Y. C., Lee B. Y., et al. Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosynthesis of RAW 264.7 cells induced by lipopolysaccharide. Biol. Pharm. Bull. 2005; 28, 652-656. Go to original source... Go to PubMed...
    94. Smolinsk A. T., Pestka J. J. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin, chamomile, ginsenoside Rb 1. ginseng, and parthenolide feverfew. Food Chem. Toxicol. 2003; 41, 1381-1390. Go to original source... Go to PubMed...
    95. Senchina D. S., Hallam J. E., Cheney D. J. Multidisciplinary perspectives on mechanisms of activity of popular immune-enhancing herbal supplements used by athletes. Front. Biol. 2013; 8, 78-100. Go to original source...
    96. Engels H. J., Fahlman M. M., Wirth J. C. Effects of ginseng on secretory IgA, performance, and recovery from interval exercise. Med. Sci. Sports Exerc. 2003; 35, 690-696. Go to original source... Go to PubMed...
    97. Gaffney B. T., Hügel H. M., Rich P. A. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci. 2001; 70, 431-442. Go to original source... Go to PubMed...
    98. Hsu M. Effect of American ginseng supplementation on cytokines and oxidative stress following an acute downhill running. Med. Sci. Sports Exerc. 2010; 42, S788. Go to original source...
    99. Jung H., Kang H., Chang Y., Kim T. Effect of Panax ginseng supplementation on muscle damage and inflammation after treadmill running in humans. Med. Sci. Sports Exerc. 2011; 43(Suppl 1), S432. Go to original source...
    100. Park S., Jung H., Hong S., Kang Y., Lee G., Kim S., Kang H., Lee C. Effects of red ginseng intake on interleukin-6 (IL-6) and cortisol responses after high-intensity exercise. Med. Sci. Sports Exerc. 2008; 40(Suppl), S432. Go to original source...
    101. Biondo P., McCargar L., Harber V., Field C. A randomized controlled trial of ginseng supplementation on the immune response to a moderate exercise stress protocol in non-athletic women. Open Nutr. J. 2010; 4, 1-10. Go to original source...
    102. Biondo P. D., Robbins S. J., Walsh J. D., McCargar L. J., Harber V. J., Field C. J. A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men. Appl. Physiol. Nutr. Metab. 2008; 33, 966-975. Go to original source... Go to PubMed...
    103. Lau W., Liang M., Sokmen B., Spalding T., Quezada L., Chuang W. Effect of Panax notoginseng (Chinese ginseng) and cycling exercise on IL-6 and cortisol in untrained non-diabetic men. Med. Sci. Sports Exerc. 2011; 43(Suppl 1), S432. Go to original source...
    104. Scaglione F., Ferrara F., Dugnani S., Falchi M., Santoro G., Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp. Clin. Res. 1990; 16, 537-542.
    105. Scaglione, F., Weiser, K., Alessandria, M. Effects of the Standardised Ginseng Extract G115® in Patients with Chronic Bronchitis A Nonblinded, Randomised, Comparative Pilot Study. Clin. Drug Invest. 2001; 21, 41-45. Go to original source...
    106. McElhaney J. E., Gravenstein S., Cole S. K., Davidson E., O'Neill D., Petitjean S., et al. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J. Am. Geriatr. Soc. 2004; 52, 13-19. Go to original source... Go to PubMed...
    107. McElhaney J. E., Goel V., Toane B., Hooten J., Shan J. J. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J. Altern. Complement. Med 2006; 12, 153-157. Go to original source... Go to PubMed...
    108. Predy G. N., Goel V., Lovlin R., Donner A., Stitt L., Basu T. K. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. Canadian Med. Assoc. J. 2005; 173, 1043-1048. Go to original source... Go to PubMed...
    109. Vohra S., Johnston B. C., Laycock K. L., Midodzi W. K., Dhunnoo I., Harris E., Baydala L. Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized, controlled trial of 2 dosing schedules. Pediatrics 2008; 122, e402-410. Go to original source... Go to PubMed...
    110. Seida J. K., Durec T., Kuhle S. North American (Panax quinquefolius) and Asian ginseng (Panax ginseng) preparations for prevention of the common cold inhealthy adults: a systematic review. Evid. Based Complement. Alternat. Med. 2011; 2011, 282151. Go to original source... Go to PubMed...
    111. Moyo M., van Staden J. Medicinal properties and conservation of Pelargonium sidoides DC. J. Ethnopharmacol. 2014; 152, 243-255. Go to original source... Go to PubMed...
    112. Navrátilová Z. Léčivý muškát Pelargonium sidoides. Prakt. Lék. 2012; 8, 290-292.
    113. Kolodziej H. Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use. In: Lis Balchin M (ed.) Geranium and Pelargonium. In Medicinal and Aromatic Plants - Industrial Profiles. New York, London: Taylor & Francis 2002; 262-290
    114. Colling J., Groenewald J.-H., Makunga N. P. Genetic alteration for increased coumarin production lead to metabolic changes in the medicinally important Pelargonium sidoides DC (Geraniaceae). Metab. Eng. 2010; 12, 561-572. Go to original source... Go to PubMed...
    115. Brendler T., van Wyk B.-E. A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). J. Ethnopharmacol. 2008; 119, 420-433. Go to original source... Go to PubMed...
    116. Lewu F. B., Adebola P. O., Afolayan A. J. Commercial harvesting of Pelargonium sidoides in the Eastern Cape, South Africa: striking a balance between resources conservation and livelihoods. J. Arid. Environ. 2007; 70, 380-388. Go to original source...
    117. Hutchings A., Scott A. H., Lewis G., Cunningham A. Zulu Medicinal Plants. Pietermaritzburg: Natal University Press 1996.
    118. Community herbal monograph on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. EMA/HMPC/ 560961/2010. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2013/02/WC500138439.pdf
    119. Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo®. Phytomedicine 2007; 14, 9-17. Go to original source... Go to PubMed...
    120. Theisen L. L., Muller C. P. EPs®7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. Antiviral Res. 2012; 94, 147-156. Go to original source... Go to PubMed...
    121. Michaelis M., Doerr H. W., Cinatl J. Jr. Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine 2011; 18, 384-386. Go to original source... Go to PubMed...
    122. Mativandlela S. P. N., Meyer J. J. M., Hussein A. A., Lall N. Antitubercular activity of compounds isolated from Pelargonium sidoides. Pharm. Biol. 2007; 45, 645-650. Go to original source...
    123. Beil W., Kilian P. EPs®7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine 2007; 14, 5-8. Go to original source... Go to PubMed...
    124. Conrad A., Jung I., Tioua D., Lalleman C., Carrapatoso F., Engels I., Daschner F. D., Frank U. Extract of Pelargonium sidoides (EPs®7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. Phytomedicine 2007; 14, 52-59. Go to original source... Go to PubMed...
    125. Kayser O., Kolodziej H., Kinderlen A. F. Immunomodulatory principles of Pelargonium sidoides. Phytother. Res. 2001; 15, 122-126. Go to original source... Go to PubMed...
    126. Thäle C., Kiderlen A. F., Kolodziej H. Anti-infective mode of action of EPs®7630 at the molecular level. Planta Med. 2008; 74, 675-681. Go to original source... Go to PubMed...
    127. Kolodziej H., Kinderlen A. F. In vitro evaluation of antibacterial and immunomodulatory acitvities of Pelargonium reinforme, Pelargonium sidoides and the related herbal drug preparation EPs®7630. Phytomedicine 2007; 14, 18-26. Go to original source... Go to PubMed...
    128. Kolodziej H., Burmeister A., Trun W., Radtke O. A., Kinderlen A. F., Ito H., Hatano T., Yoshida T., Foo L. L. Tannins and related compounds induce nitric oxide synthase and cytokines genes expression in Leishmania major - infected macrophage-like RAW 264.7 cells. Bioorg. Med. Chem. 2005; 13, 6470-6476. Go to original source... Go to PubMed...
    129. Radtke O. A., Kinderlen A. F., Kayser O., Kolodziej H. Gene expression profiles of inducible nitric oxide synthase and cytokines in Leishmania major - infected macrophage-like RAW 264.7 cells treated with gallic acid. Planta Med. 2004; 70, 924-928. Go to original source... Go to PubMed...
    130. Kamin W., Ilyenko L. I., Malek F. A., Kieser M. Treatment of acute bronchitis with EPss 7630: randomized, controlled trial in children and adolescents. Pediatr. Int. 2012; 54, 219-226. Go to original source... Go to PubMed...
    131. Kamin W., Maydannik V. G., Malek F. A., Kieser M. Efficacy and tolerability of EPss 7630 in patients (aged 6-18 years old) with acute bronchitis: a randomized, double-blind, placebo-controlled clinical dose-finding study. Acta Paediatr. 2010; 99, 537-543. Go to original source... Go to PubMed...
    132. Matthys H., Funk P. EPSs 7630 improves acute bronchitic symptoms and shortens time to remission: Results of a randomised, double-blind, placebo-controlled, multicentre trial. Planta Med. 2008; 74, 686-692. Go to original source... Go to PubMed...
    133. Chuchalin A. G., Berman B., Lehmacher W. Treatment of acute bronchitis in adults with a Pelargonium sidoides preparation (EPss 7630) a randomised, double-blind controlled trial. Explore 2005; 1, 437-445. Go to original source... Go to PubMed...
    134. Bachert C., Schapowal A., Funk P., Kieser M. Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPss 7630: a randomized, double-blind, placebo-controlled trial. Rhinology 2009; 47, 51-58.
    135. Tahan F., Yaman M. Can the Pelargonium sidoides root extract EPss 7630 prevent asthma attacks during viral infections of the upper respiratory trac tin children? Phytomedicine 2013; 20, 148-150. Go to original source... Go to PubMed...
    136. Bereznoy V. V., Riley D. S., Wasmer G., Heger M. Efficacy of extract of Pelargonium sidoides in children with acute non-group A betaemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial. Altern. Ther. Health Med. 2003, 9, 68-79.
    137. Timmer A., Günther J., Rücker G., Motschall E., Antes G., Kern W. V. Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst. Rev. 2008; 3, CD006323. Go to original source... Go to PubMed...
    138. Leugnerová G. 2008. Thymus vulgaris L. - mateřídouška obecná, tymián/dúška tymiánová. Dostupné na: http://botany.cz/cs/thymus-vulgaris/, datum citace 25.1.2016
    139. Basch E., Ulbricht C., Hammerness P., Bevins A., Sollars D. Thyme (Thymus vulgaris L.). Thymol. J. Herb. Pharmacother. 2004; 4, 49-67. Go to original source...
    140. Community herbal monograph on Thymus vulgaris L. and Thymus zygis L., herba. EMA/HMPC/342332/2013. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_Community_herbal_monograph/2014/06/WC500167812.pdf
    141. Blumenthal M. (ed.) The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston: Integrative Medicine Communications 1998.
    142. Czygan F. C., Hiller K. Thymi herba. In: Wichtl M (ed.) Herbal drugs and Phytopharmaceuticals. Medpharm Scientific Publishers 2004; 607-610.
    143. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd ed. Secaucus, NJ: Lavoisier Publishing 1999.
    144. Spiewak R., Skorska C., Dutkiewics J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001; 44, 235-239. Go to original source... Go to PubMed...
    145. Manou I., Bouillard L., Devleeschouwer M. J., et al. Evaluation of the preservative properties of Thymus vulgaris essentials oil in topically applied formulations under a challenge test. J. Appl. Microbiol. 1998; 84, 368-376. Go to original source... Go to PubMed...
    146. Twetman S., Petersson L. G. Interdental caries incidence and progression in relation to mutant streptococci suppression after chlorhexidine-thymol varnic treatments in schoolchildren. Acta Odontol. Scand. 1999; 57, 144-148. Go to original source... Go to PubMed...
    147. Shapiro S., Guggenheim B. The action of thymol on oral bacteria. Oral Microbiol. Immunol. 1995; 10, 241-246. Go to original source... Go to PubMed...
    148. Bakkali F., Averbeck S., Averbeck D., Idaomar M. Biological effects of essential oils - A review. Food Chem. Toxicol. 2008; 46, 446-475. Go to original source... Go to PubMed...
    149. Di Pasqua R., Betts G., Hoskins N., Edwards M., Ercolini D., Mauriello G. Membrane toxicity of antimicrobial compounds from essential oils. J. Agric. Food Chem. 2007; 55, 4863-4870. Go to original source... Go to PubMed...
    150. Ipek E., Zeytinoglu H., Okay S., Tuylu B. A., Kurcuoglu M., Baser K. H. C. Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test. Food Chem. 2005; 93, 551-556. Go to original source...
    151. Franzios G., Mirotsou M., Hatziapostolou E., Kral J., Scouras Z. G., Mavragani-Tsipidou P. Insecticidal and genotoxic activities of mint essential oils. J. Agric. Food Chem. 1997; 45, 2690-2694. Go to original source...
    152. Santana-Rios G., Orner G. A., Amantana A., Provost C., Wu S. Y., Dashwood R. H. Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay. Mutat. Res. 2001; 495, 61-74. Go to original source... Go to PubMed...
    153. Cal K. Skin penetration of terpenes from essential oils and topical vehicles. Planta Med. 2006; 72, 311-316. Go to original source... Go to PubMed...
    154. Radulovic N. S., Blagojevic P. D., Stojanovic-Radic Z. Z., Stojanovic N. M. Antimicrobial Plant Metabolites: Structural Diversity and Mechanism of Action. Curr. Med. Chem. 2013; 20, 932-952. Go to original source...
    155. Friedman M. Chemistry and multibeneficial bioactivities of carvacrol (4-isopropyl-2-methylphenol., a component of essential oils produced by aromatic plants and spices. J. Agric. Food Chem. 2014; 62, 7652-7670. Go to original source... Go to PubMed...
    156. Langeveld W. T., Veldhuizen E. J. A., Burt S. A. Synergy between essential oil components and antibiotics: A review. Cr. Rev. Microbiol. 2014; 40, 76-94. Go to original source... Go to PubMed...
    157. Bassolé I. H. N., Juliani H. R. Essential oils in combination and their antimicrobial properties. Molecules 2012; 17, 3989-4006. Go to original source... Go to PubMed...
    158. Nowotarska S., Nowotarski K., Friedman M. Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers. Molecules 2014; 19, 7497-7515. Go to original source... Go to PubMed...
    159. Helander I. M., Alakomi H., Latva-Kala K., Mattila-Sandholm T., Pol I., Smid E. J., Gorris L. G. M., von Wright A. Characterization of the action of selected essential oil components on Gram-negative bacteria. J. Agric. Food Chem. 1998; 46, 3590-3595. Go to original source...
    160. Lambert R. J. W., Skandamis P. N., Coote P. J., Nychas G. J. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J. Appl. Microbiol. 2001; 91, 453-462. Go to original source... Go to PubMed...
    161. Walsh S. E., Maillard J. Y., Russell A. D., Catrenich C. E., Charbonneau D. L., Bartolo R. G. Activity and mechanisms of action of selected biocidal agents on Gram-positive and negative bacteria. J. Appl. Microbiol. 2003; 94, 240-247. Go to original source... Go to PubMed...
    162. Horváth G., Kovács K., Kocsis B., Kustos I. Effect of thyme (Thymus vulgaris L.) essential oil and its main constituents on the outer membrane protein composition of Erwinia strains studied with microfluid chip technology. Chromatographia 2009; 70, 1645-1650. Go to original source...
    163. Di Pasqua R., Mamone G., Ferranti P., Ercolini D., Mauriello G. Changes in the proteome of Salmonella enterica serovar Thompson as stress adaptation to sublethal concentrations of thymol. Proteomics 2010; 10, 1040-1049. Go to original source... Go to PubMed...
    164. Liu Y., Song X., He J., Zheng X., Wu H. Synthetic derivatives of chrysin and their biological activities. Med. Chem. Res. 2014; 23, 555-563. Go to original source...
    165. Cushnie T. P., Lamb A. J. Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents 2005; 26, 343-356. Go to original source... Go to PubMed...
    166. Sithisarn P., Michaelis M., Schubert-Zsilavecz M., Cinatl J. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells. Antiviral Res. 2013; 97, 41-48. Go to original source... Go to PubMed...
    167. Reiter M., Brandt W. Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittelforschung 1985; 35, 408-414.
    168. Meister A., Bernhardt G., Christoffel V., et al. Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med. 1999; 65, 512-516. Go to original source... Go to PubMed...
    169. Keyhanmanesh R., Boskabady M. H. Relaxant effects of differrent fractions from Thymus vulgaris on guinea-pig tracheal chains. Biol. Res. 2012; 45, 67-73. Go to original source... Go to PubMed...
    170. van den Broucke C. O., Lemli J. A. Pharmacological and chemical investigation of thyme liquid extracts. Planta Med. 1981; 41, 129-135. Go to original source... Go to PubMed...
    171. Marsik P., Kokoska L., Landa P., Nepovim A., Soudek P., Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med. 2005; 71, 739-742. Go to original source... Go to PubMed...
    172. de Cássia da Silveira e Sá R., Andrade L. N., de Sousa D. P. A Review on Anti-Inflammatory Activity of Monoterpenes. Molecules 2013; 18, 1227-1254. Go to original source... Go to PubMed...
    173. Landa P., Kokoska L., Pribylova M., Vanek T., Marsik P. In vitro Anti-inflammatory Activity of Carvacrol: Inhibitory Effect on COX-2 Catalyzed Prostaglandin E2 biosynthesis. Arch. Pharm. Res. 2009; 32, 75-78. Go to original source... Go to PubMed...
    174. Patil R. H., Babu R. L., Naveen Kumar M., Kiran Kumar K. M., Hegde S. M., Nagesh R., Ramesh G. T., Sharma S. C. Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. Inflammation 2016; 39, 138-147. Go to original source... Go to PubMed...
    175. Arango D., Diosa-Toro, M., Rojas-Hernandez L. S., Cooperstone J. L., Schwartz S. J., Mo X., Jiang J., Schmittgen T. D., Doseff A. I. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Mol. Nutr. Food Res. 2015; 59, 763-772. Go to original source... Go to PubMed...
    176. Seo H.-S., Sikder M. A., Lee H. J., Ryu J., Lee C. J. Apigenin inhibits tumor necrosis factor-α-induced production and gene expression of mucin through regulating nuclear factor-kappa B signaling pathway in airway epithelial cells. Biomol. Therapeutics 2014; 22, 525-531. Go to original source... Go to PubMed...
    177. Kritas S. K., Saggini A., Varvara G., Murmura G., Caraffa A., Antinolfi P., Toniato E., Pantalone A., Neri G., Frydas S., et al. Luteolin inhibits mast cell-mediated allergic inflammation. J. Biol. Reg. Homeostat. Agents 2013; 27, 955-959.
    178. Kaas P. J. Atemwegsinfekte im Kindesalter: Anwendungsbeobachtung bestätigt Effizienz einer Thymian zubereitung. Natura Med. 2003; 18, 2-4.
    179. Kemmerich B., Eberhardt R., Stammer H. Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled clinical trial. Arzneimittelforschung 2006; 56, 652-660. Go to original source... Go to PubMed...
    180. Kemmerich B. Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicentre clinical trial. Arzneimittelforschung 2007; 57, 607-615. Go to original source... Go to PubMed...
    181. Ernst E., März R., Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997; 4, 287-293. Go to original source... Go to PubMed...
    182. Gruenwald J., Graubaum H. J., Busch R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. A double-blind, randomized, placebo-controlled clinical trial. Arzneimittelforschung 2005; 55, 669-676. Go to original source... Go to PubMed...
    183. Ismail C., Willer G., Steindl H. Bronchipret bei akuter Bronchitis. Schweiz. Zschr. Ganzheitsmedizin. 2003; 15, 171-175.
    184. Lorenzi S., Placucci F., Vincezi C., et al. Allergic contact dermatitis due to thymol. Contact Dermatitis 1995; 33, 439-440. Go to original source... Go to PubMed...
    185. Zava D. T., Dollbaum C. M., Blen M. Estrogen and progestin aktivity of foods, herbs, and spices. Proc. Soc. Exp. Biol. Med. 1998; 217, 369-378. Go to original source... Go to PubMed...

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