JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2016, 65(3):94-98 | DOI: 10.36290/csf.2016.019

The influence of hyaluronan addition on thickness, weight, uniformity of mass and water content of mucoadhesive films

Veronika Walicová, Jan Gajdziok*, Markéta Gajdošová, David Vetchý
Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Characteristics of the buccal mucoadhesive films (film thickness, film weight, uniformity of mass and moisture content) prepared by solvent casting method were tested in this experimental study. The formulations consisted either of one mucoadhesive polymer (sodium hyaluronate of two different molecular weights and sodium carboxymethylcellulose) or combinations thereof. On the basis of the aforementioned tests, it was determined that water content was influenced by the molecular weight of sodium hyaluronate as well as by the ratio of mucoadhesive polymers in the composition. The composition of the films influences also other tested parameters.

Keywords: buccal mucoadhesive films; solvent casting method; sodium hyaluronate; sodium carboxymethylcellulose; water content
Grants and funding:

This work was supported by project IGA VFU Brno No. 308/2015/FaF.

Received: January 13, 2016; Accepted: February 20, 2016; Published: March 1, 2016  Show citation

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Walicová V, Gajdziok J, Gajdošová M, Vetchý D. The influence of hyaluronan addition on thickness, weight, uniformity of mass and water content of mucoadhesive films. Čes. slov. farm. 2016;65(3):94-98. doi: 10.36290/csf.2016.019.
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