JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2015, 64(6):287-288

From an old drug to a new one: Synthesis of valproate from 5,5-dipropylbarbituric acid

Oldřich Farsa*, Pavol Brka
Department of Chemical Drugs, Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Published: June 1, 2015  Show citation

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Farsa O, Brka P. From an old drug to a new one: Synthesis of valproate from 5,5-dipropylbarbituric acid. Čes. slov. farm. 2015;64(6):287-288.
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References

  1. Addictive Compounds Act No. 167/1998 Coll.
  2. Government Regulation Concerning the lists of Addictive Compounds No. 463/2013 Coll.
  3. Aspelund H., Skoglund L. The stability of the sodium salts of some soporifics of the barbituric acid series in solution. Acta Acad. Aboensis Math. et Phys. 1937; 10, 14-36.
  4. Mokrosz J., Bojarski J. Hydrolysis of barbituric acid derivatives. Part IV. Hydrolysis of derivatives without a shielding steric effect. Polish Journal of Chemistry 1982; 56, 491-500.
  5. Helavi V. B., Solabannavar S. B., Desai U. V., Mane R. B. Microwave assisted hydrolysis of Meldrum's acid derivatives and decarboxylation of derived malonic acids. J. Chem. Research (S), 2003; 2003, 174-175. Go to original source...
  6. Toussaint O., Capdevielle P., Maumy M. The Copper(I)-Catalyzed Decarboxylation of Malonic Acids; A New Mild and Quantitative Method. Synthesis 1986; 1986. 1029-1031. Go to original source...
  7. Barton H., Mokrosz J., Bojarski J., Klimczak M. Photochemical degradation of barbituric acid derivatives. Part 1. Products of photolysis and hydrolysis of pentobarbital. Pharmazie 1980; 35, 155-158. Go to original source...




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