JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2014, 63(4):160-166 | DOI: 10.36290/csf.2014.032

Studies of local anaesthetics: Part 205. Studies of stability of heptacainium chloride and carbisocainium chloride using an accelerated non-isothermal test

Mária Stankovičová*, Andrea Lašáková, Veronika Medlenová, Želmíra Bezáková, Jozef Čižmárik
Katedra farmaceutickej chémie, Farmaceutická fakulta Univerzity Komenského, Bratislava, SR

The paper studies the kinetics of alkaline hydrolysis and stability under non-isothermal conditions of heptacainium chloride and carbisocainium chloride in the medium of aqueous-ethanolic solution of sodium hydroxide c = 0.1 mol/l and buffer solutions of values of pH 7.0 and pH 8.0. The results of the study of the kinetics of hydrolysis by means of anon-isothermal test - rate constants and activation energy values served as the basis for exact evaluation of the stability of these potential pharmaceuticals. The objective of the paper links up with the previous studies of these substances.

Keywords: heptacainium chloride; carbisocainium chloride; stability; non-isothermal kinetics

Received: May 27, 2014; Accepted: June 25, 2014; Published: April 1, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Stankovičová M, Lašáková A, Medlenová V, Bezáková Ž, Čižmárik J. Studies of local anaesthetics: Part 205. Studies of stability of heptacainium chloride and carbisocainium chloride using an accelerated non-isothermal test. Čes. slov. farm. 2014;63(4):160-166. doi: 10.36290/csf.2014.032.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Čižmárik J., Borovanský A., Švec P. Štúdium lokálnych anestetík LII. Piperydinoetylestery kyselín alkoxyfenylkarbámových. Acta Facult. Pharm. Univ. Comenianae 1976; 29, 76-77. Go to original source...
    2. Beneš P., Švec P., Kozlovský J., Borovanský A. Bazické estery kyselin o-alkoxykarbanilových s lokálně anestetickým a antiarytmickým účinkem. Čes. slov. Farm. 1978; 27, 167-172.
    3. Švec P., Čižmárik J., Béderová E., Borovanský A. Štúdium lokálnych anestetík LIII. Farmakologické vlastnosti heptakaínu. Acta Facult. Pharm. Univ. Comenianae 1976; 29, 96-99.
    4. Kozlovský J., Čižmárik J., Pešák M., Inczinger F., Borovanský A. Antiarrhythmic activity of heptacaine and some of its derivatives. Arzneim.-Forsch 1982; 32, 1032-1036.
    5. Blešová M., Bachratá M., Bezáková Ž., Beneš L., Borovanský A. Analytické hodnocení karbizokaíniumchloridu. Čes. slov. Farm. 1985; 34, 163-167.
    6. Bezáková Ž., Čižmárik J., Blešová M., Bachratá M., Borovanský A. Štúdium lokálnych anestetík. LXXXII. Stabilita heptakaíniumchloridu. Farm. Obzor 1986; 55, 19-24.
    7. Bezáková Ž., Bachratá M., Blešová M., Borovanský A. Stabilita karbizokaíniumchloridu a pentakaíniumchloridu. Farm. Obzor 1986; 55, 195-203.
    8. Stankovičová M., Bachratá M., Bezáková Ž., Blešová M., Čižmárik J., Borovanský A. Štúdium kinetiky alkalickej hydrolýzy karbizokaíniumchloridu, pentakaíniumchloridu a heptakaíniumchloridu. Čes. slov. Farm. 1987; 36, 9-15.
    9. Stankovičová M., Čižmárik J., Bachratá M. Kinetics of alkaline hydrolysis of heptacaine chloride basic analogues. Chem. Papers 1990; 44, 171-176.
    10. Stankovičová M., Bezáková Ž., Lukášová-Masná P., Lukáš L. Kinetics of alkaline hydrolysis of potential local anaesthetics - The basic esters of phenylcarbamic acids. Acta Facult. Pharm. Univ. Comenianae. 2009; 56, 128-135.
    11. Čižmárik J., Lehotay J., Bednáriková A. Štúdium lokálnych anestetík CLVII. Chromatografické vlastnosti pentakaínu, karbizokaínu, heptakaínu a jeho 3- a 4-polohových izomérov v RP systéme HPLC. Čes. slov. Farm. 2001; 50, 233-237.
    12. Lehotay J., Čižmárik J., Hromuľáková K. HPLC of heptacaine position isomers. Pharmazie 1996; 51, 731-733.
    13. Lehotay J., Čižmárik J., Branšteterová E. Study of local anesthetics. Part 128. HPLC study of the degradation of heptacaine and carbisocaine in urine, human and rabbit serums. Acta Pharmaceutica Hungarica, 1995; 65, 95-96.
    14. Gallová J., Andriamainty F., Uhríková D., Balgavý P. Interaction of local anesthetic heptacaine homologs with phosphatidylcholine bilayers: spin label ESR study. Biochim. Biophys. Acta - Biomembranes. 1997; 1325, 189-196. Go to original source... Go to PubMed...
    15. Andriamainty F., Čižmárik J., Malík I., Horváth S. Štúdium lokálnych anestetík: Časť 183. Micelizácia a termodynamické parametre heptakaíniumchloridu v prostredí KBr. Čes. slov. Farm. 2008; 57, 119-125. Go to original source...
    16. Gališinová J., Čižmárik J., Andriamainty F., Malík I. Štúdium lokálnych anestetík: Časť 193. Štúdium vplyvu teploty a prídavku soli na micelizáciu heptakaínium-perchlorátu vo vodnom prostredí. Čes. slov. Farm. 2010; 59, 272-276.
    17. Čižmárik J., Andriamainty F., Malík I., Sedlárová E. Štúdium lokálnych anestetík. Časť 176. Štúdium micelizácie a termodynamických parametrov heptakaíniumchloridu vo vodnom a alkoholickom prostredí. Farm. Obzor 2007; 76, 133-138.
    18. Čižmárik J., Vitková Z., Herdová P. Štúdium lokálnych anestetík: Časť 196. Formulation of the local anaesthetic heptacaine into hydrogel on the basis of chitosan. Čes. slov. Farm. 2012; 61, 60-61.
    19. Vitková Z., Gardavská K., Čižmárik J., Rak J. Influence of auxiliary substances on the release of heptacaine from the drug form. Acta Pharmaceutica Hungarica. 1996; 66, 191-195.
    20. Čižmárik J., Lehotay J., Hromuľáková K., Pokorná M., Lacuška M. HPLC separation of enantiomers of carbisocaine. Pharmazie 1997; 52, 402.
    21. Kersten D., Göber B. Chemische Stabilitätsprüfung von Arzneimitteln im Lang- und Kurzzeittest-Methodenvergleich. Pharmazie 1984; 39, 218-219.
    22. Rogers A. R. An accelerated storage test with programmed temperature rise. J. Pharm. Pharmacol. 1963; 15, 101T-105T. Go to original source... Go to PubMed...
    23. Beňo P., Truplová E., Ostrovská V., Stankovičová M. Stabilita liečiv a liekov. 1. vyd. Bratislava: Veda 2003.

    Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.