Čes. slov. farm. 2014, 63(3):123-126 | DOI: 10.36290/csf.2014.024

Formulation of benzethonium chloride into gels

Jozef Čižmárik¹, Zuzana Vitková¹, Petra Herdová^1,*, Alexandra Kodadová², Daniel Vími²

¹ Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie

² Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra galenickej farmácie

This study is focused on the preparation of gels with antimicrobial effects. A quaternary ammonium salt, benzethonium chloride, in a concentration of 0.01-0.5% (w/w) was employed as the drug. The humectant employed was propylene glycol in concentrations of 5% and 10% (w/w). Two types of polymers, chitosan and hydroxyethyl cellulose, in the same concentrations of 2.5% (w/w), were used for gel preparation. Finally the flow properties, rheological parameters and pH values of the gels were evaluated. Based on the obtained results, the samples of the gels prepared on the basis of chitosan and hydroxyethyl cellulose, which have the following optimum composition shown below, were found:
2,5% (w/w) CHIT + 0,5% (w/w) BZCl + 10% (w/w) PG;
2,5% (w/w) HEC + 0,5% (w/w) BZCl + 5% (w/w) PG.

Keywords: benzethonium chloride; chitosan; hydroxyethyl cellulose; rheological properties

Received: May 13, 2014; Accepted: May 23, 2014; Published: March 1, 2014  Show citation