JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2012, 61(3):79-86

Molecularly imprinted polymers

Natalia Denderz1,*, Jozef Lehotay1, Jozef Čižmárik2
1 Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Slovak Republic
2 Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Chemistry

Nowadays about 28 million different simple or complex chemical entities are known. Today we cannot imagine the life without different kinds of drugs, cosmetics, pesticides, food additives or stimulants. In the recent period in the field of analytical chemistry or pharmacy more modern techniques or methodologies are required which will allow selective determination of different kinds of analytes, especially in complex biological matrices. The imprinted polymers are very often used for the preparation of samples before analysis and this procedure can reduce the possibilities of interferences. This paper deals with the characterization, preparation, properties and application of imprinted polymers in the field of drugs, cosmetics, food and biological materials.

Keywords: molecularly imprinted polymers; chromatography; extraction; drugs
Grants and funding:

Presently molecularly imprinted polymers are the most promising and popular research objects in chemistry. They are used as sorbents in SPE and SPME, as stationary phases in HPLC or CEC, as sensors, catalysts, binding assays, reusable protecting groups or polymer-supported reagents in organic synthesis. Due to their properties they are excellent materials for sample pre-concentration, cleaning or extraction, especially for complex matrices.

Received: April 6, 2011; Accepted: July 20, 2011; Published: March 1, 2012  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Denderz N, Lehotay J, Čižmárik J. Molecularly imprinted polymers. Čes. slov. farm. 2012;61(3):79-86.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Poole C. F.: New trends in solid-phase extraction. Trends Anal. Chem. 2003; 22, 362-373. Go to original source...
    2. Altun Z., Abdel-Rehim M., Blomberg L. G.: New trends in sample preparation: on-line microextraction in packed syringe (MEPS) for LC and GC applications Part III: Determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent and MEPS-LC-MS-MS. J. Chromatogr. B 2004; 813, 129-135. Go to original source... Go to PubMed...
    3. Huck C. W., Bonn G. K.: Recent developments in polymer-based sorbents for solid-phase extraction, Review. J. Chromatogr. A 2000; 885; 51-72. Go to original source... Go to PubMed...
    4. Bielicka-Daszkiewicz K., Voelkel A.: Theoretical and experimental methods of determination of the breakthrough volume of SPE sorbents. Talanta 2009; 80, 614-621. Go to original source... Go to PubMed...
    5. Stevenson D.: Molecular imprinted polymers for solid-phase extraction. Trends Anal. Chem. 1999; 18, 154-158. Go to original source...
    6. Picó Y., Fernández M., Ruiz M. J., Font G.: Current trends in solid-phase-based extraction techniques for the determination of pesticides in food and environment, Review. J. Biochem. Bioph. Methods 2007; 70, 117-131. Go to original source... Go to PubMed...
    7. Xu Z. X., Gao H. J., Zhang L. M., Chen X. Q., Qiao X. G.: The Biomimetic Immunoassay Based on Molecularly Imprinted Polymer: A omprehensive Review of Recent Progress and Future Prospects. J. Food Sci. 2011; 76, R69-R75. Go to original source... Go to PubMed...
    8. Bui B. T. S., Haupt K.: Molecularly imprinted polymers: synthetic receptors in bioanalysis, Review. Anal. Bioanal. Chem. 2010; 398, 2481-2492. Go to original source... Go to PubMed...
    9. Shi Y., Zhang J., Shi D., Jiang M., Zhu Y., Mei S., Zhou Y., Dai K., Lu B.: Selective solid-phase extraction of cholesterol using molecularly imprinted polymers and its application in different biological samples. J. Pharm. Biomed. Anal. 2006; 42, 549-555. Go to original source... Go to PubMed...
    10. He Ch., Long Y., Pan J., Li K., Liu F.: Application of molecularly imprinted polymers to solid-phase extraction of analytes from real samples, Review. J. Biochem. Bioph. Methods 2007; 570, 133-150. Go to original source... Go to PubMed...
    11. Valtchev M., Palm B.S., Schiller M., Steinfeld U.: Development of sulfamethoxazole-imprinted polymers for the selective extraction from waters. J. Hazard. Mater. 2009; 170, 722-728. Go to original source... Go to PubMed...
    12. Zi-Hui M., Qin L.: Determination of degradation products of nerve agents in human serum by solid-phase extraction using molecularly imprinted polymer. Anal. Chim. Acta 2001; 435, 121-127. Go to original source...
    13. Tom L. A., Foster N.: Development of a molecularly imprinted polymer for the analysis of avermectin. Anal. Chim. Acta 2010; 680, 79-85. Go to original source... Go to PubMed...
    14. Alexander C., Andersson H. S., Andersson L. I., Ansell R. J., Kirsch N., Nicholls I. A., O'Mahony J., Whitcombe M. J.: Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003, Review. J. Mol. Recognit. 2006; 19, 106-180. Go to original source... Go to PubMed...
    15. Theodoridis G., Manesiotis P.: Selective solid-phase extraction sorbent for caffeine made by molecular imprinting. J. Chromatogr. A 2002, 948, 163-169. Go to original source... Go to PubMed...
    16. Izenberg N. R., Murrray G. M., Pilato R. S., Baird L. M., Levin S. M., Van Houten K. A.: Astrobiological molecularly imprinted polymer sensors. Planet. Space Sci. 2009; 57, 846-853. Go to original source...
    17. Luliński P.: Polimery ze śladem molekularnym w naukach farmaceutycznych. Cz. I. Podstawy procesu tworzenia śladu molekularnego. Zastosowanie w syntezie leków i echnologii postaci leku. Polimery 2010; 55, 799-805. Go to original source...
    18. Whitcombe M. J., Vulfson E. N.: Imprinted Polymers. Adv. Mater. 2001; 13, 467-468. Go to original source...
    19. Ansell R. J., Kriz D., Mosbach K.: Molecularly imprinted polymers for bioanalysis: chromatography, binding assays and biomimetic sensors. Curr. Opin. Biotechnol. 1996; 7, 89-94. Go to original source... Go to PubMed...
    20. Turiel E., Martin-Esteban A.: Molecularly imprinted polymers for sample preparation: A eview, Review. Anal. Chim. Acta 2010; 668, 87-99. Go to original source... Go to PubMed...
    21. Yan H., Row K. H.: Characteristic and synthetic approach of molecularly imprinted polymer. Int. J. Mol. Sci. 2006; 7, 155-178. Go to original source...
    22. Pan J., Xue X., Wang J., Xie H., Wu Z.: Recognition property and preparation of Staphylococcus aureus protein A-imprinted polyacrylamide polymers by inverse-phase suspension and bulk polymerization. Polymer 2009; 50, 2365-2372. Go to original source...
    23. Jing T., Gao X. D., Wang P., Wang Y., Lin Y. F., Zong X. Ch., Zhou Y. K., Mei S. R.: Preparation of high selective molecularly imprinted polymers for tetracycline by precipitation polymerization. Chin. Chem. Lett. 2007; 18, 1535-1538. Go to original source...
    24. Kitahara K., Yoshihama I., Hanada T., Kokuba H., Arai S.: Synthesis of monodispersed molecularly imprinted polymer particles for high-performance liquid chromatographic separation of cholesterol using templating polymerization in porous silica gel bound with cholesterol molecules on its surface. J. Chromatogr. A 2010; 1217, 7249-7254. Go to original source... Go to PubMed...
    25. Turiel E., Tadeo J. L., Cormack P. A. G., Martin-Esteban A.: HPLC imprinted-stationary phase prepared by precipitation polymerization for the determination of thiabendazole in fruit. The Analyst 2005; 130, 1601-1607. Go to original source... Go to PubMed...
    26. Hoa K., Yeh W., Tung T., Liao J.: Amperometric detection of morphine based on poly(3,4-ethylenedioxythiophene) immobilized molecularly imprinted polymer particles prepared by precipitation polymerization. Anal. Chim. Acta 2005; 542, 90-96. Go to original source...
    27. Tamayo F. G., Casillas J. L., Martin-Esteban A.: Highly selective fenuron-imprinted polymer with a homogeneous binding site distribution prepared by precipitation polymerization and its application to the clean-up of fenuron in plant samples. Anal. Chim. Acta 2003; 482, 165-173. Go to original source...
    28. Pérez-Moral N., Mayes A. G.: Comparative study of imprinted polymer particles prepared by different polymerisation methods. Anal. Chim. Acta 2004; 504, 15-21. Go to original source...
    29. Jin Y., Jiang M., Shi Y., Lin Y., Peng Y., Dai K., Lu B.: Narrowly dispersed molecularly imprinted microspheres prepared by a modified precipitation polymerization method. Anal. Chim. Acta 2008; 612, 05-113. Go to original source... Go to PubMed...
    30. Hosoya K., Yoshizako K., Shirasu Y., Kimata K., Araki T., Tanaka N., Haginaka J.: Molecularly imprinted uniform-size polymer-based stationary phase for high-performance liquid chromatography. Structural contribution of cross-linked polymer network on specific molecular recognition. J. Chromatogr. A 1996; 728, 139-147. Go to original source...
    31. Haginaka, J., Sanbe, H.: Uniform-sized molecularly imprinted polymers for 2-arylpropionic acid derivatives selectively modified with hydrophilic external layer and their applications to direct serum injection analysis. Anal. Chem. 2000; 72, 5206-5210. Go to original source... Go to PubMed...
    32. Liua Y., Liub Z., Gaoa J., Daia J., Hana J., Wanga Y., Xiea J., Yan Y.: Selective adsorption behavior of Pb(II) by mesoporous silica SBA-15-upported Pb(II)-imprinted polymer based on surface molecularly imprinting technique. J. Hazard. Mater. 2011; 186, 197-205. Go to original source... Go to PubMed...
    33. Djozan D., Ebrahimi B., Mahkam M., Farajzadeh M. A.: Evaluation of a new method for chemical coating of aluminum wire with molecularly imprinted polymer layer. Application for the fabrication of triazines selective solid-phase microextraction fiber. Anal. Chim. Acta 2010; 674, 40-48. Go to original source... Go to PubMed...
    34. Čižmárik J., Lachová M., Lehotay J., Skačáni I.: Extraction of 1-methyl-2-piperidinoethylesters of alkoxyphenylcarbamic acids from human plasma by imprinted polymers and its comparison with classic solid phase extraction. Čes. slov. Farm. 2009; 58, 78-82.
    35. Lachová M., Lehotay J., Skačáni I., Čižmárik J.: Influence of polymerization mixture composition on molecularly imprinted polymers properties prepared with 1-methyl-2-piperidinoethylester of decyloxyphenylcarbamic acid as a template. Modern Analytical Chemistry. Prague 2008; 49-52.
    36. Jafari M.T., Rezaei B., Javaheri M.: A new method based on electrospray ionisation ion mobility spectrometry (ESI-IMS) for simultaneous determination of caffeine and theophylline, Food Chem. 2011; 126, 1964-1970. Go to original source... Go to PubMed...
    37. Shih-Kai Ch., Mei-Jywan S.: Via zinc(II) protoporphyrin to the synthesis of poly(ZnPP-MAA-EGDMA) for the imprinting and selective binding of bilirubin. Biomaterials 2009; 30, 1255-1262. Go to original source... Go to PubMed...
    38. Meng Z., Wang J., Zhou L., Wang Q., Zhu D.: High performance cocktail functional monomer for making molecule imprinting polymer. Anal. Sci. 1999; 15, 141-144. Go to original source...
    39. Yoshimi Y., Arai R., Nakayama S.: Influence of the solvent on nature of gate effect in molecularly imprinted membrane. Anal. Chim. Acta 2010; 682, 110-116. Go to original source... Go to PubMed...
    40. Moreira F. T. C., Kamel A. H., Guerreiro R. L., Azevedo V., Sales M. G. F.: New potentiometric sensors based on two competitive recognition sites for determining tetracycline residues using flow-through system. Procedia Engineering 2010; 5, 1200-1203. Go to original source...
    41. Gavrilovic I., Mitchell K., Brailsford A. D., Cowan D. A., Kicman A.T., Ansell R. J.: A molecularly imprinted receptor for separation of testosterone and epitestosterone, based on a steroidal cross-linker, Steroids 2011; 76, 478-483. Go to original source... Go to PubMed...
    42. Joshi V. P., Kulkarni M. G., Mashelkar R. A.: Enhancing adsorptive separations by molecularly imprinted polymers: Role of imprinting techniques and system parameters. Chem. Eng. Sci. 2000; 55, 1509-1522. Go to original source...
    43. Zhiong Ch., Yuanzong L.: The role of molecular recognition in regulating the catalytic activity of peroxidase-like polymers imprinted by a reductant substrate. J. Mol. Catal. A: Chem. 2006; 256, 9-15. Go to original source...
    44. Lachová M., Lehotay J., Skačáni I., Čižmárik J.: Possibility of using of molecular imprinted polymers on sorption selectivity of some phenyl carbamic derivatives. Farm. Obzor 2008; 77, 37-40.
    45. Saifuddin, N., Nur, Y. A. A., Abdullah, S. F.: Microwave enhanced synthesis of chitosan-graft-polyacrylamide molecular imprinting polymer for selective removal of 17β-estradiol at trace concentration. Asian J. Biochem. 2011; 6, 38-54. Go to original source...
    46. Zhou J., He X., Li Y.: An acrylamide-based molecularly imprinted polymer for the efficient recognition of optical amino acid hydantoins. Anal. Commun. 1999; 36, 243-246. Go to original source...
    47. Thazhathuparambil E. M., Krishnapillai P. P., Talasila P. R.: Synthesis of surface imprinted nanospheres for selective removal of uranium from simulants of Sambhar salt lake and ground water. J. Hazard. Mater. 2011; 188, 384-390. Go to original source... Go to PubMed...
    48. Luliński P., Maciejewska D.: Impact of functional monomers, cross-linkers and porogens on morphology and recognition properties of 2-(3,4-dimethoxyphenyl)ethylamine imprinted polymers. Mater. Sci. Eng., C 2011; 31, 281-289. Go to original source...
    49. Lämmerhofer M., Gargano A.: Monoliths with chiral surface functionalization for enantioselective capillary electrochromatography. J. Pharm. Biomed. Anal. 2010; 53, 1091-1123. Go to original source... Go to PubMed...
    50. Luo X., Zhan Y., Huang Y., Yang L., Tu X., Luo S.: Removal of water-soluble acid dyes from water environment using a novel magnetic molecularly imprinted polymer. J. Hazard. Mater. 2011; 187, 274-282. Go to original source... Go to PubMed...
    51. Surong M., Da W., Ming J., Bin L., Jae-Min L., Yi-Kai Z., Yong-Ill L.: Determination of trace bisphenol A in complex samples using selective molecularly imprinted solid-phase extraction coupled with capillary electrophoresis. Microchem. J. 2011; 98, 150-155. Go to original source...
    52. Moring S. E., Wong O. S., Stobaugh J. F.: Target specific sample preparation from aqueous extracts with molecular imprinted polymers. J. Pharm. Biomed. Anal. 2002; 27, 719-728. Go to original source... Go to PubMed...
    53. Augusto de Barros L., Martins I., Rath S.: A selective molecularly imprinted polymer-solid phase extraction for the determination of fenitrothion in tomatoes. Anal. Bioanal.Chem. 2010; 397, 1355-1361.
    54. Zhang T., Liu F., Chen W., Wang J., Li K.: Influence of intramolecular hydrogen bond of templates on molecular recognition of molecularly imprinted polymers. Anal. Chim. Acta 2001; 450, 53-61. Go to original source...
    55. Guan G., Liu B., Wang Z., Zhang Z.: Imprinting of molecular recognition Sites on nanostructures and its applications in chemosensors. Review, Sensors 2008; 8, 8291-8320. Go to original source... Go to PubMed...
    56. Xu X., Zhu L., Chen L.: Separation and screening of compounds of biological origin using molecularly imprinted polymers.. Chromatogr. B 2004; 804, 61-69. Go to original source... Go to PubMed...
    57. Soares da Silva M., Väo E. R., Temtem M., Mafra L., Caldeira J., Aguiar-Ricardo A., Casimiro T.: Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases. Biosens. Bioelectron. 2010; 25, 1742-1747.
    58. Lachová M., Lehotay J., Čižmárik J.: Applications of molecularly imprinted polymers in analytical and pharmaceutical chemistry. Čes. slov. Farm. 2007; 56, 159-164.
    59. Baggiani C., Anfossi L., Giovannoli C.: Solid phase extraction of food contaminants using molecular imprinted polymers. Anal. Chim. Acta 2007; 591, 29-39. Go to original source... Go to PubMed...
    60. Turiel E., Martin-Esteban A.: Molecularly imprinted polymers for solid-phase microextraction, Review. J. Sep. Sci. 2009; 32, 3278-3284. Go to original source... Go to PubMed...
    61. Bunte G., Hurttlen J., Pontius H., Hartlieb K., Krause H.: Gas phase detection of explosives such as 2,4,6-trinitrotoluene by molecularly imprinted polymers. Anal. Chim. Acta 2007; 591, 49-56. Go to original source... Go to PubMed...
    62. Kirsch N., Hedin-Dahlström J., Henschel H., Whitcombe M. J., Wikman S., Nicholls I. A.: Molecularly imprinted polymer catalysis of a Diels-Alder reaction. J. Mol. Catal. B: Enzym. 2009; 58, 10-117. Go to original source...
    63. Theodoridis G., Zacharis C. K., Tzanavaras P. D., Themelis D.G., Economou A.: Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography. J. Chromatogr. A 2004; 1030, 69-76. Go to original source... Go to PubMed...
    64. Molinelli A., Weiss R., Mizaikoff B.: Advanced solid phase extraction using molecularly imprinted polymers for the determination of quercetin in red wine. J. Agric. Food. Chem., 2002; 50, 1804-1808. Go to original source... Go to PubMed...
    65. Su S., Zhang M., Li B., Zhang H., Dong X.: HPLC determination of sulfamethazine in milk using surface-imprinted silica synthesized with iniferter technique. Talanta 2008; 76, 1141-1146. Go to original source... Go to PubMed...
    66. Mhaka B., Cukrowska E., Bui B. T. S., Ramström O., Haupt K., Tutu H., Chimuka L.: Selective extraction of triazine herbicides from food samples based on a combination of a liquid membrane and molecularly imprinted polymers. J. Chromatogr. A 2009; 1216, 6796-6801. Go to original source... Go to PubMed...
    67. Xu Z., Hu Y., Hu Y., Li G.: Investigation of ractopamine molecularly imprinted stir bar sorptive extraction and its application for trace analysis of β-agonists in complex samples. J. Chromatogr. A 2010; 1217, 3612-3618. Go to original source... Go to PubMed...
    68. Brambilla G., Fiori M., Rizzo B., Crescenzi V., Masci G.: Use of molecularly imprinted polymers in the solid-phase extraction of clenbuterol from animal feeds and biological matrices. J. Chromatogr. B 2001; 759, 27-32. Go to original source... Go to PubMed...
    69. Carabias-Martinez R., Rodriguez-Gonzalo E., Herrero-Hernandez E.: Determination of triazines and dealkylated and hydroxylated metabolites in river water using a propazine-imprinted polymer. J. Chromatogr. A 2005; 1085, 199-206. Go to original source... Go to PubMed...
    70. Hoshina K., Horiyama S., Matsunaga H., Haginaka J.: Simultaneous determination of non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography-tandem mass spectrometry using molecularly imprinted polymers as a pretreatment column, J. Pharm. Biomed. Anal. 2011; 55, 916-922. Go to original source... Go to PubMed...
    71. Teixeira Tarley C. R., Kubota L. T.: Molecularly-imprinted solid phase extraction of catechol from aqueous effluents for its selective determination by differential pulse voltammetry. Anal. Chim. Acta 2005; 548, 11-19. Go to original source...
    72. Lai J.-P., Niessner R., Knopp D.: Benzo[a]pyrene imprinted polymers: Synthesis, characterization and SPE application in water and coffee samples. Anal. Chim. Acta 2004; 522, 137-144. Go to original source...
    73. Gros M., Pizzolato T., Petrovi M., Lopez de Alda M.J., Barcelo D.: Trace level determination of β-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry. J. Chromatogr. A 2008; 1189, 374-384. Go to original source... Go to PubMed...
    74. Jiang M., Zhang J. H., Mei S. R., Shi Y., Zou L. J., Zhu Y. X.: Direct enrichment and high performance liquid chromatography analysis of ultra-trace bisphenol A in water samples with narrowly dispersible bisphenol A imprinted polymeric microspheres column. J. Chromatogr. A 2006; 1110, 27-34. Go to original source... Go to PubMed...
    75. Watabe Y., Kondo T., Morita M., Tanaka N., Haginaka J., Hosoya K.: Determination of bisphenol A in environmental water at ultra-low level by high-performance liquid chromatography with an effective on-line pretreatment device. J. Chromatogr. A 2004; 1032, 45-49. Go to original source... Go to PubMed...
    76. San Vicente B., Villoslada F. N., Moreno-Bondi M. C.: Continuous solid-phase extraction and preconcentration of bisphenol A in aqueous samples using molecularly imprinted columns. Anal. Chim. Acta 2004; 380, 115-22. Go to original source... Go to PubMed...
    77. Qu S., Wang X., Tong Ch., Wu J.: Metal ion mediated molecularly imprinted polymer for selective capturing antibiotics containing beta-diketone structure. J. Chromatogr. A 2010; 1217, 8205-8211. Go to original source... Go to PubMed...
    78. Bjarnason B., Chimuka L., Ramstrom O.: On-line solid-phase extraction of triazine herbicides using a molecularly imprinted polymer for selective sample enrichment. Anal. Chem. 1999; 71, 2152-2156. Go to original source... Go to PubMed...
    79. Caro E., Marce R. M., Cormack P. A. G., Sherrington D. C., Borrull F.: Molecularly imprinted solid-phase extraction of naphthalene sulfonates from water. J. Chromatogr. A 2004; 1047, 175-180. Go to original source...
    80. Caro E., Marce R. M., Cormack P. A. G., Sherrington D. C., Borrull F.: On-line solid-phase extraction with molecularly imprinted polymers to selectively extract substituted 4-chlorophenols and 4-nitrophenol from water. Short communication. J. Chromatogr. A 2003; 995, 233-238. Go to original source... Go to PubMed...
    81. Le Moullec S., Begos A., Pichon V., Bellier B.: Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction. J. Chromatogr. A 2006; 1108, 7-13. Go to original source... Go to PubMed...
    82. Zhu X., Yang J., Su Q., Cai J., Gao Y.: Selective solid-phase extraction using molecularly imprinted polymer for the analysis of polar organophosphorus pesticides in water and soil samples. J. Chromatogr. A 2005; 1092, 161-169. Go to original source... Go to PubMed...
    83. Yang L., Zhao X., Zhou J.: Selective enrichment and determination of nicosulfuron in water and soil by a stir bar based on molecularly imprinted polymer coatings. Anal. Chim. Acta 2010; 670, 72-77. Go to original source... Go to PubMed...
    84. Kootstra P. R., Kuijpers C. J. P. F., Wubs K. L., van Doorn D., Sterk S. S., van Ginkel L. A., Stephany R. W.: The analysis of β-agonists in bovine muscle using molecular imprinted polymers with ion trap LCMS screening. Anal. Chim. Acta 2005; 529, 75-81. Go to original source...
    85. Crescenzi C., Bayoudh S., Cormack P. A. G., Klein T., Ensing K.: Determination of clenbuterol in bovine liver by combining matrix solid phase dispersion and molecularly imprinted solid phase extraction followed by liquid chromatography/electrospray ion trap multiple stage mass spectrometry. Anal. Chem. 2001; 73, 2171-2177. Go to original source... Go to PubMed...
    86. Widstrand Ch., Larsson F., Fiori M., Civitareale C., Mirante S., Brambilla G.: Evaluation of MISPE for the multi-residue extraction of β-agonists from calves urine. J. Chromatogr. B 2004; 804, 85-91. Go to original source... Go to PubMed...
    87. Hu Y., Li Y., Liu R., Tan W., Li G.: Magnetic molecularly imprinted polymer beads prepared by microwave heating for selective enrichment of β-agonists in pork and pig liver samples. Talanta 2011; 84, 462-470. Go to original source... Go to PubMed...
    88. Martin P. D., Jones G. R., Stringer F., Wilson I. D.: Comparison of extraction of a β-blocker from plasma onto a molecularly imprinted polymer with liquid-liquid extraction and solid phase extraction methods. J. Pharm. Biomed. Anal. 2004, 35, 1231-1239. Go to original source... Go to PubMed...
    89. Huanga H. Ch., Lin Ch. I., Joseph A. K., Lee Y. D.: Photo-lithographically impregnated and molecularly imprinted polymer thin film for biosensor applications, J. Chromatogr. A 2004; 1027, 263-268. Go to original source... Go to PubMed...
    90. Zaidi S. A., Lee S. M., Cheong W. J.: Open tubular capillary columns with basic templates made by the generalized preparation protocol in capillary electrochromatography chiral separation and template structural effects on chiral separation capability. J. Chromatogr. A 2011; 1218, 1291-1299. Go to original source... Go to PubMed...
    91. Andac M., Say R., Denizli A.: Molecular recognition based cadmium removal from human plasma. J. Chromatogr. B 2004; 811, 119-126. Go to original source...
    92. Yavuz H., Say R., Denizli A; Iron removal from human plasma based on molecular recognition using imprinted beads. Mater. Sci. Eng., C 2005; 25, 521-528. Go to original source...
    93. Hu S. G., Li L., He X. W.: Comparison of trimethoprim molecularly imprinted polymers in bulk and in sphere as the sorbent for solid-phase extraction and extraction of trimethoprim from human urine and pharmaceutical tablet and their determination by high-performance liquid chromatography. Anal. Chim. Acta 2005; 537, 215-222. Go to original source...
    94. Bereczki A., Tolokan A., Horvai G., Horvath V., Lanza F., Hall A. J.: Determination of phenytoin in plasma by molecularly imprinted solid-phase extraction. J. Chromatogr. A 2001; 930, 31-38. Go to original source... Go to PubMed...
    95. Andersson L. I., Hardenborg E., Sandberg-Ställ M., Möller K., Henriksson J., Bramsby-Sjöström I., Olsson L., Abdel-Rehim M.: Development of a molecularly imprinted polymer based solid-phase extraction of local anaesthetics from human plasma. Anal. Chim. Acta 2004; 526, 147-154. Go to original source...
    96. Lachová M., Lehotay J., Skačáni I., Čižmárik J.: Isolation of some derivatives of phenylcarbamic acid from human plasma using molecularly imprinted polymers. J. Liq. Chromatogr. Related Technol. 2009; 32, 167-181. Go to original source...
    97. Liu X., Liu J., Huang Y., Zhao R., Liu G., Chen Y.: Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly imprinted polymer. J. Chromatogr. A 2009; 1216, 7533-7538. Go to original source... Go to PubMed...
    98. Blomgrena A., Berggrena Ch., Holmberga A., Larssona F., Sellergren B., Ensing K.: Extraction of clenbuterol from calf urine using a olecularly imprinted polymer followed by quantitation by high-performance liquid chromatography with UV detection. J. Chromatogr. A 2002; 975, 157-164. Go to original source... Go to PubMed...
    99. Khorrami A.R., Rashidpur A.: Design of a new cartridge for selective solid phase extraction using molecularly imprinted polymers: Selective extraction of theophylline from human serum samples. Biosens. Bioelectron. 2009; 25, 647-651. Go to original source... Go to PubMed...
    100. Javanbakht M., Attaranb A. M., Namjumanesh M. H., Esfandyari-Manesha M., Akbari-Adergani B.: Solid-phase extraction of tramadol from plasma and urine samples using a ovel water-compatible molecularly imprinted polymer. J. Chromatogr. B 2010; 878, 1700-1706. Go to original source... Go to PubMed...
    101. Boos K. S., Fleischer C. T.: Multidimensional on-line solid-phase extraction (SPE) using restricted access materials (RAM) in combination with molecular imprinted polymers (MIP), Fresenius J. Anal. Chem. 2001; 371, 16-20. Go to original source... Go to PubMed...
    102. Yang J., Hu Y., Cai J., Zhu X. L., Su Q. D.: A new molecularly imprinted polymer for selective extraction of cotinine from urine samples by solid-phase extraction. Anal. Bioanal.Chem. 2006; 384, 761-768. Go to original source... Go to PubMed...
    103. Caro E., Marce R. M., Cormack P. A. G., Sherrington D. C., Borrull F.: A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction. J. Chromatogr. B 2004; 813, 137-143. Go to original source... Go to PubMed...
    104. Kriz D., Mosbach K.: Competitive amperometric morphine sensor based on an agarose immobilised molecularly imprinted polymer. Anal. Chim. Acta 1995; 300, 71-75. Go to original source...
    105. Xie J., Chen L., Li Ch., Xu X.: Selective extraction of functional components derived from herb in plasma by using a molecularly imprinted polymer based on 2,2-bis (hydroxymethyl)butanol trimethacrylate. J. Chromatogr. B 2003; 788, 233-242. Go to original source... Go to PubMed...
    106. Mullett W. M., Walles M., Levsen K., Borlak J., Pawliszyn J.: Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography-mass spectrometry. J. Chromatogr. B 2004; 801, 297-306. Go to original source... Go to PubMed...
    107. B. Sellergren: Direct drug determination by selective sample enrichment on an imprinted polymer. Anal. Chem. 1994; 66, 1678-1582. Go to original source...
    108. Lachová M., Lehotay J., Karasová G., Skačáni I., Armstrong D. W.: Isolation of L-theanine from plant material using a molecularly imprinted polymer. J. Liq. Chromatogr. Related Technol. 2007; 30, 2045-2058. Go to original source...
    109. De Smeta D., Kodeckb V., Dubruelb P., Van Peteghema C. E. Schachtb, De Saeger S.: Design of an imprinted clean-up method for mycophenolic acid in maize. J. Chromatogr. A 2011; 1218, 1122-1130. Go to original source... Go to PubMed...
    110. Lachová M., Lehotay J., Skačáni I., Čižmárik J.: Selective solid-phase extraction of phenylcarbamic acid derivatives from rat serum by molecularly imprinted polymer. Acta Chim. Slovakia 2008; 1, 175-179.
    111. Lachová M., Lehotay J., Skačáni I., Čižmárik J.: Molecularly imprinted solid-phase extraction of 1-methyl-2-piperidinoethylesters of alkoxyphenylcarbamic acid from human plasma, comparison with classical solid-phase extraction. J. Liq. Chromatogr. Related Technol. 2009; 32, 2293-2306. Go to original source...
    112. Möller K., Nilsson U., Crescenzi C.: Investigation of matrix effects of urine on a molecularly imprinted solid-phase extraction. J. Chromatogr. B 2004; 811, 171-176. Go to original source... Go to PubMed...
    113. Claude B., Morin P., Bayoudh S., de Ceaurriz J.: Interest of molecularly imprinted polymers in the fight against doping Extraction of tamoxifen and its main metabolite from urine followed by high-performance liquid chromatography with UV detection. J. Chromatogr. A 2008; 1196-1197, 81-88. Go to original source... Go to PubMed...
    114. Theodoridis G., Kantifes A., Manesiotis P., Raikos N., Tsoukali-Papadopoulou H.: Preparation of a molecularly imprinted polymer for the solid-phase extraction of scopolamine with hyoscyamine as a ummy template molecule. J. Chromatogr. A 2003; 987, 103-109. Go to original source... Go to PubMed...
    115. Nakamura M., Ono M., Nakajima T., Ito Y., Aketo T., Haginaka J.: Uniformly sized molecularly imprinted polymer for atropine and its application to the determination of atropine and scopolamine in pharmaceutical preparations containing scopolia extract. J. Pharm. Biomed. Anal. 2005; 37, 231-237. Go to original source... Go to PubMed...
    116. Hu Y., Wang Y., Chen X., Hu Y., Li G.: A novel molecularly imprinted solid-phase microextraction fiber coupled with high performance liquid chromatography for analysis of trace estrogens in fishery samples. Talanta 80 2010; 2099-2105. Go to original source... Go to PubMed...
    117. Hu S. G., Wang S. W., He X. W.: An amobarbital molecularly imprinted microsphere for selective solid-phase extraction of phenobarbital from human urine and medicines and their determination by high-performance liquid chromatography. Analyst 2003; 128, 1485-1489. Go to original source... Go to PubMed...
    118. Yin J., Yang G., Chen Y.: Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers. J. Chromatogr. A 2005; 1090, 68-75. Go to original source... Go to PubMed...
    119. Caro E., Marce R.M., Cormack P.A.G., Sherrington D.C., Borrull F.: Novel enrofloxacin imprinted polymer applied to the solid-phase extraction of fluorinated quinolones from urine and tissue samples. Anal. Chim. Acta 2006; 562, 145-151. Go to original source...
    120. Caro E., Marce R. M., Cormack P. A. G., Sherrington D. C., Borrull F.: Synthesis and application of an oxytetracycline imprinted polymer for the solid-phase extraction of tetracycline antibiotics. Anal. Chim. Acta 2005; 552, 81-86. Go to original source...
    121. Zhang M. L., Xie J. P., Zhou Q., Chen G. Q., Liu Z.: On-line solid-phase extraction of ceramides from yeast with ceramide III imprinted monolith. J. Chromatogr. A 2003; 984, 173-183. Go to original source... Go to PubMed...
    122. Dong X. C., Wei W. A., Ma S. J., Sun H., Li Y., Guo J. Q.: Molecularly imprinted solid-phase extraction of (-)-ephedrine from chinese ephedra. J. Chromatogr. A 2005; 1070, 125-130. Go to original source... Go to PubMed...
    123. Zhu L. L., Xu X. J.: Selective separation of active inhibitors of epidermal growth factor receptor from Caragana jubata by molecularly imprinted solid-phase extraction. J. Chromatogr. A 2003; 991, 151-158. Go to original source... Go to PubMed...
    124. Mena M. L., Agui L., Martinez-Ruiz P., Yanez-Sedeno P., Reviejo A. J., Pingarron J. M.: Molecularly imprinted polymers for on-line clean up and preconcentration of chloramphenicol prior to its voltammetric determination. Anal. Bioanal.Chem. 2003; 376, 18-25. Go to original source... Go to PubMed...
    125. Sambe H., Hoshina K., Moaddel R., Wainer I. W., Haginaka J.: Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization. J. Chromatogr. A 2006; 1134, 88-94. Go to original source... Go to PubMed...

    Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.