Čes. slov. farm. 2012, 61(1):60-61
Study of local anaesthetics - Part 196. Formulation of the local anaesthetic heptacaine into hydrogel on the basis of chitosan
- 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University Bratislava
- 2 Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University
The study aimed to formulate the local anaesthetic heptacaine into hydrogels on the basis of chitosan. The gel-creating compounds used included natural polymers - three different types of chitosan, namely those of a medium molecular weight, from the shells of shrimp, and from the bumblebees species Bombus terrestris. The prepared hydrogels were evaluated on the basis of their rheological properties and drug liberation. From the point of drug liberation and flow properties, the optimal gel composition was as follows: 0.1% heptacaine + 2% chitosan (medium molecular weight) + 0.2% carbaethopendecinium bromide.
Keywords: hydrogel; heptacaine; chitosan; drug liberation
Received: September 29, 2011; Accepted: October 26, 2011; Published: January 1, 2012 Show citation
References
- Čižmárik J., Borovanský A., Švec P. Study of local anaesthetics. Part 52. Piperidinoethyl ester of alkoxyphenylcarbamic acids. Acta Facultatis Pharm Univ Com. 1976; 29, 53-80.
- Čižmárik J., Borovanský A., Švec P. N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidinium chloride, Heptacaine a new local Anaesthetic. Pharmazie 1978; 33, 297-298.
- Vitková Z., Gardavská K., Čižmárik J., Rak J., Šubová, M. Study of local anaesthetics. Part 130: In-vitro and in-vivo evaluation of dosage forms with heptacaine. Acta Facultatis Pharm Univ Com 2002; 49, 117-124.