Čes. slov. farm. 2011, 60(6):290-295
Study of local anesthetics - Part 195. Study of micellization of pentacainium chloride in methanol and ethanol solutions
- Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej chémie
The critical micellar concentrations of pentacainium chloride in methanol and ethanol solutions with different concentrations were determined by the spectrophotometric method in the UV region of the spectrum at the temperature range of T = 278.15-308.15 K and pH ≈ 4.5-5.0. The dependence of cmc on temperature T turned out to be U-shaped. The influence of the n-alkanols, methanol and ethanol, on the critical micellar concentration was studied. The cmc values show that micelle formation occurred more easily in methanol than in ethanol solutions. Simultaneously the influence of various concentrations of alcohols was studied. The critical micellar concentration rises with an increasing concentration of alcohol up to some value, then cmc decreases.
Keywords: local anaesthetics; pentacainium chloride; ethanol; methanol; critical micellar concentration; micellization; spectrophotometry
Received: June 20, 2011; Accepted: August 15, 2011; Published: June 1, 2011 Show citation
References
- Akhter, M. S.: Effect of solubilization of alcohols on critical micelle concentration of non-aqueous micellar solutions. Colloids and Surfaces 1999; 157, 203-210.
Go to original source... - Akhter, M. S., Al-Alawi, S. M.: Influence of alcohols on the critical micelle concentration of non-aqueous micellar solutions. Colloids and Surfaces 2000; 164, 247-255. Go to original source...
- Akhter, M. S., Al-Alawi, S. M.: Micellar behaviour of cetyltrimethylammonium bromide in N-methyl acetamide - alkanol and N,N-dimethyl acetamide - alkanol mixtures. Colloids and Surfaces 2002; 196, 163-174. Go to original source...
- Chalabala, M. a kol.: Technologie léků. Praha: Galén 1997; 66-261.
- Beneš, L., Borovanský, A., Kopáčová, L.: Alkoxycarbanilic Acid Esters with High Local Anaesthetic Activity. Arzneim. Forsch. 1969; 19, 1902-1903.
- Chen, L. J., Lin, S. Y., Huang, C. C.: Effect of Hydrophobic Chain Length of Surfactants on Enthalpy - Entropy Compensation of Micellization. J. Phys. Chem. 1998; 102, 4350-4356. Go to original source...
- Vlachy, N. a kol.: Influence of additives and cation chain length on the kinetic stability of supersaturated catanionic systems. Colloids and Surfaces 2009; 338, 135-141. Go to original source...
- Andriamainty, F., Čižmárik, J., Zúdorová, Z., Malík, I., Sedlárová, E.: Influence of alcohols on the critical micelle concentration of heptacainium chloride. Pharmazie 2007; 62, 77-78.
- Čižmárik, J., Andriamainty, F., Malík, I., Sedlárová, E.: Štúdium micelizácie a termodynamických parametrov heptakaíniumchloridu vo vodnom a alkoholickom prostredí. Farm. Obzor 2007; 56, 133-138.