JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2011, 60(5):211-218

Clinical significance of cytochrome P450 genetic polymorphism - part III. cytochrome P450 2C19

Jana Ďuricová*, Milan Grundmann
Ústav klinické farmakologie Lékařské fakulty OU a FN Ostrava

Cytochrome P450 2C19 is the important cause for great differences in the pharmacokinetics of a number of clinically used drugs. Several studies have demonstrated that the CYP2C19 polymorphism is important for several drugs and may be associated with the occurrence of clinically relevant side effects. The third part of this paper focuses on the influence of genetic polymorphism of cytochrome P450 2C19 on drug effect.

Keywords: cytochrome P450; genetic polymorphism; CYP2C19

Received: January 31, 2011; Accepted: April 11, 2011; Published: May 1, 2011  Show citation

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Ďuricová J, Grundmann M. Clinical significance of cytochrome P450 genetic polymorphism - part III. cytochrome P450 2C19. Čes. slov. farm. 2011;60(5):211-218.
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