Čes. slov. farm. 2011, 60(4):182-188
Prosolv® Easytab as a new multifunctional co-processed dry binder: a study of the properties of tablets and energy evaluation of the compaction process
- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Czech Republic
The paper studies the tensile strength and disintegration time of tablets made from the new co-processed dry binder Prosolv® Easytab. The results are compared with Prosolv® SMCC 90 and the physical mixtures of Prosolv SMCC 90 with Explotab (1% or 1.5%) and Pruv (0.5% or 1%). It also evaluates the mixtures with the active ingredients ascorbic acid and acetylsalicylic acid. The process of compaction of the new excipient is studied also from the energetic aspect. The tablets made from the substance Prosolv Easytab possessed a lower strength than those from Prosolv SMCC 90 and the physical mixtures of Prosolv SMCC 90 with Explotab and Pruv. The disintegration time of tablets was markedly shorter in the case of the substance Prosolv Easytab than in Prosolv SMCC 90, the shortest being in the tablets made from the physical mixtures of substances. From the energetic aspect, Prosolv Easytab was the best compressible one, because under the given compression force the value of the maximal energy was the lowest one of the all tableting compositions under study, primarily due to a lower energy for friction and the energy accumulated by the tablet.
Keywords: Prosolv Easytab; Prosolv SMCC 90; tensile strength of tablets; disintegration time; force-displacement profile
Grants and funding:
The study was supported by the grant MSM 0021620822 and by the firm JRS PHARMA, which supplied the samples of the dry binders tested.
Received: May 26, 2011; Accepted: June 9, 2011; Published: April 1, 2011 Show citation
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