Čes. slov. farm. 2011, 60(2):54-60

Pelletization of melts and liquids

Miloslava Rabišková

Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků

During the second half of the last century, pelletization methods based on wetting were developed, e.g. agglomeration in coating pans, pelletization plates or fluid-bed equipment, layering of the drug in solution or suspension on inactive spherical cores, extrusion/spheronization and later on also rotoagglomeration in rotogranulators or rotoprocessors. These technologies have become a requisite part of industrial production of solid dosage forms. At present, numerous experimental papers deal with pellet preparation from melts and liquids. These new pelletization methods are the topic of the present article. Pellet preparation from melts is represented by three methods, i.e. fluid hot melt agglomeration, hot melt extrusion, and freeze pelletization. Jet cutting and cryopelletization are the techniques dealing with pellet preparation from liquids.

Keywords: fluid hot melt agglomeration; hot melt extrusion; freeze pelletization; jet cutting; cryopelletization

Received: January 27, 2011; Accepted: February 2, 2011; Published: February 1, 2011  Show citation