Čes. slov. farm. 2010, 59(6):272-276
Study of local anesthetics. Part 193. Study of temperature and salt-induced micellization of hepatacainium perchlorate in aqueous solution
- Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej chémie
The critical micellar concentration of heptacainium perchlorate in aqueous NaCl solutions with different concentrations was determined by the spectrophotometric method in the UV region of the spectrum at the temperature range of t = 5-35 °C and pH ≈ 4.5-5.0. The dependence of cmc on temperature T turned out to be of U-shaped. The cmc decreases to a certain minimum and then increases with the temperature. The influence of sodium chloride on the critical micellar concentration was studied. A gentle increase in cmc is seen for increasing concentration of aqueous NaCl solution (up to 0.3 mol/l), but vice versa a rapid decrease in cmc is observed from 0.4 mol/l concentration of NaCl solution. The influence of perchlorate against the chloride ion on the critical micellar concentration was also studied.
Keywords: local anaesthetics; heptacainium perchlorate; sodium chloride; critical micellar concentration; micellization; spectrophotometry
Received: October 21, 2010; Accepted: November 20, 2010; Published: June 1, 2010 Show citation
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