JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2010, 59(4):155-159

Antimicrobial substances produced by lactic acid bacteria

H. Kiňová Sepová*, A. Bílková, F. Bilka, L. Bezáková
Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra bunkovej a molekulárnej biológie liečiv, Slovenská republika

Lactic acid bacteria comprise several genera of Gram-positive bacteria that are known for the production of different antimicrobial substances. Lactic acid and related organic acids, usual metabolites of saccharide metabolism, inhibit the growth of other microbes mainly by lowering pH. Bacteriocins, proteinaceous antimicrobial substances, are produced ribosomally and those of lactic acid bacteria are well examined. Some species, for example Lactobacillus reuteri, are able to produce specific substances with miscellaneous structures. One of them, reutericyclin, a derivate of tetramic acid, is the first discovered antibiotic produced by a lactic acid bacterium. Reuterin, a complex of 3-hydroxypropionaldehyde and its related forms, is a strong antimicrobial substance produced by several species of the genus Lactobacillus. Because of a non-pathogenic character of lactic acid bacteria, they can be used as food preservatives or as promising antimicrobials in human and/or animal therapy.

Keywords: lactic fermentation bacteria; probiotics; antimicrobially active substances

Received: June 21, 2010; Accepted: August 2, 2010; Published: April 1, 2010  Show citation

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Kiňová Sepová H, Bílková A, Bilka F, Bezáková L. Antimicrobial substances produced by lactic acid bacteria. Čes. slov. farm. 2010;59(4):155-159.
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