JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2009, 58(5):191-199

Methods of preparation of microparticles in pharmaceutical technology

M. Bajerová*, K. Dvořáčková, J. Gajdziok, R. Masteiková, M. Rabišková
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků

The review paper particularly focuses on the methods of preparation and characterization of microparticles as well as the characterization and examples of their possible use in pharmacotherapy. Microparticles as a multiple dosage form usually rank among the medicaments of the second generation, i.e. the medicaments in which controlled release is possible. In comparison with the classic dosage forms they exert lower undesirable effects and higher stability. Administration of medicaments in this dosage form produces higher efficiency of therapy and simultaneously improved compliance of the patient. The most widely used methods of preparation of microparticles include phase separation (simple or complex), evaporation of the solvent, spray drying, and cross-linking methods based on the formation of covalent or ionic bonds. Marginally, it is possible to use the extrusion-spheronization methods, formation and coating of microparticles in the fluid layer, and in situ polymerization.

Keywords: microparticles; preparation of microparticles; polymers; controlled release

Received: November 2, 2009; Accepted: November 11, 2009; Published: May 1, 2009  Show citation

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Bajerová M, Dvořáčková K, Gajdziok J, Masteiková R, Rabišková M. Methods of preparation of microparticles in pharmaceutical technology. Čes. slov. farm. 2009;58(5-6):191-199.
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