JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2009, 58(2):83-87

Use radionuclide x-ray fluorescence analysis for determination of heavy metals content in dextrans in solid and liquid state

V. Jánošová*, O. Štroffeková, M. Sýkorová
Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej analýzy a nukleárnej farmácie

The aim of this study was to determine heavy metals in dextrans samples and to observe the influence of sample preparation before the analysis on the detection limit by radionuclide x-ray fluorescence analysis (XRF). The content of elements Mn, Fe, Cu, Co, Zn, Pb, As, Hg and Cd was determined in dextran tablets, their ashes after the mineralization and in solutions after the preconcetration by precipitation with thioacetamide and after following filtration of created sulphides through the membrane filter. Calculated detection limits proved the advantage of preconcentration of elements from the liquid state. The results suggest the possible use of combination of XRF with this preconcentration method in quality control of drugs.

Keywords: heavy metals; dextran; preconcentration; thioacetamide; X-ray fluorescence
Grants and funding:

Táto práca je zahrnutá do výskumných projektov grantovej agentúry MŠ SR VEGA č. 1/4299/07, 1/0003/08 a grantu UK/97/2008.

Received: March 23, 2009; Accepted: April 20, 2009; Published: February 1, 2009  Show citation

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Jánošová V, Štroffeková O, Sýkorová M. Use radionuclide x-ray fluorescence analysis for determination of heavy metals content in dextrans in solid and liquid state. Čes. slov. farm. 2009;58(2):83-87.
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