JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2008, 57(3):111-114

Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures

Z. Kršková, J. Martin*, J. Péč, J. Dušek
Charles University in Prague, Faculty of Pharmacy, Department of Pharmacognosy

This work focused on the cultivation of S. baicalensis Georgii in vitro cultures and on the possibilities of increasing the production of secondary metabolites in these cultures. The aim of the study was to determine whether the baicalin transport through vacuolar membrane is dependent on the presence of Mg-ATP. Our results showed that Mg-ATP had a significant effect on the ratio of baicalin and baicalein content and on the transport speed of these flavonoids. Therefore, the transport mechanism for baicalin are probably some of the MRP proteins which are the subfamily of the ABC transporters.

Keywords: Scutellaria; baicalin; baicalein; Mg-ATP; ABC transporters

Received: February 26, 2008; Accepted: March 28, 2008; Published: March 1, 2008  Show citation

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Kršková Z, Martin J, Péč J, Dušek J. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. Čes. slov. farm. 2008;57(3):111-114.
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