Čes. slov. farm. 2008, 57(2):63-69

Semisynthetic cellulose derivatives as the base of hydrophilic gel systems

M. Bajerová^1,*, J. Gajdziok¹, K. Dvořáčková¹, R. Masteiková¹, P. Kollár²

¹ Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků

² Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav humánní farmakologie a toxikologie

The field of drug technology widely ulilizes gel systems of high-molecular substances, which have a number of advantages, such as low toxicity, availability, unique physical properties, biocompatibility, mucoadhesivity, and others. Gel systems are used in the field of local as well as general therapy, in both shape-specific and shape-non-specific dosage forms, in medicaments of the first, second, and third generations. An important group of gels employed in pharmacy are hydrophilic gels or hydrogels, most frequently composed of hydrophilic polymers of natural, semisynthetic and synthetic origin. Though cellulose derivatives as the representatives of polymers of semisynthetic origin are used in pharmaceutical technology for a long time, their research continues and their other possible uses are being searched for. Their advantages include especially safety, easy availability, and a relatively low price. The review paper describes selected cellulose derivatives, their properties and uses in pharmaceutical technology with regard to their use in the field of production of gel systems.

Keywords: hydrogel; controlled drug release; cellulose derivatives; oxycellulose

Grants and funding:

Tato práce je součástí projektu ev. Č. 2A - 1TP1/073 realizovaného za finanční podpory z prostředků státního rozpočtu prostřednictvím MPO a grantu IGA VFU Brno 21/007/FaF.

Received: January 8, 2007; Accepted: January 29, 2008; Published: February 1, 2008  Show citation