JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2007, 56(1):17-20

The influence of the extrusion die on pellet characteristics

M. Rabišková, D. Weingartová, A. Häring
Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Characteristics of pellets (pellet size distribution, their mean diameter, density, hardness, friability, repose angle, Hausner ratio, and drug dissolution profiles) prepared by axial and radial extrusion/spheronization were examined in this experimental study. The formulation consisted of binary mixtures of theophylline, a drug slightly soluble in water, and Avicel® CL 611 as an excipient. Different characteristics were found in the samples prepared using the different extrusion dies: the axially situated extrusion die produces the pellets of higher hardness and density, and slower dissolution profiles. Differences in drug dissolution profiles should be considered, nevertheless they are not significant. All pellet samples showed low friability and excellent flow properties.

Keywords: pellets; theophylline; Avicel® CL 611; extrusion, spheronization; axial extrusion; radial extrusion

Received: November 21, 2006; Accepted: December 18, 2006; Published: January 1, 2007  Show citation

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Rabišková M, Weingartová D, Häring A. The influence of the extrusion die on pellet characteristics. Čes. slov. farm. 2007;56(1):17-20.
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