JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2005, 54(5):235-239

A Study of Physicochemical Properties of 2-, 3-, 4-Alkoxyphenylcarbamic Acid Derivatives with a Substituted N-Phenylpiperazine Moiety in the Basic Part

I. Malík1, E. Sedlárová1, J. Čižmárik1, F. Andriamainty1, J. Csöllei2
1 Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej chémie, SR
2 Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav chemických léčiv

The paper presents the study of some physicochemical properties of 2-, 3-, 4-alkoxyphenylcarbamic acid derivatives with various substituted N-phenylpiperazin-1-yl moiety in the basic part of the molecule. Elemental analysis, melting point, solubility, surface activity, dissociation constant and some lipophilicity parameters i.e. - partition coefficient, capacity factor obtained from HPLC, and RM values from reversed-phase thin-layer chromatography were determined.

Keywords: substituted N-phenylpiperazine moiety; physicochemical properties; phenylcarbamates

Received: March 4, 2005; Accepted: April 27, 2005; Published: May 1, 2005  Show citation

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Malík I, Sedlárová E, Čižmárik J, Andriamainty F, Csöllei J. A Study of Physicochemical Properties of 2-, 3-, 4-Alkoxyphenylcarbamic Acid Derivatives with a Substituted N-Phenylpiperazine Moiety in the Basic Part. Čes. slov. farm. 2005;54(5):235-239.
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