JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2005, 54(5):226-230

Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Cetirizine-Containing Hydrogels

Z. Capková, Z. Vitková, S. Uhrovská
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie, SR

The paper is concerned with the formulation of the antihistamine cetirizine into hydrogels. The cellulose derivatives hydroxyethylcellulose (HEC) and methylcellulose (MC) were employed to prepare hydrogels. As auxiliary substances from the group of humectants are indispensable components of hydrogels, the paper examines their effect (glycerol - GL, propylene glycol - PG, and sorbitol - SO) on the rheological properties and pharmaceutical availability of cetirizine in its formulation into hyrogel. The obtained results show that from the viewpoint of dermal administration for cetirizine at this stage of research hydrogels of the following composition are optimal: 3 %HEC + 15% GL and 2.5% MC + 10% SO.

Keywords: hydrogels; cetirizine; hydroxyethylcellulose; methylcellulose; humectants

Received: March 8, 2005; Accepted: May 25, 2005; Published: May 1, 2005  Show citation

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Capková Z, Vitková Z, Uhrovská S. Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Cetirizine-Containing Hydrogels. Čes. slov. farm. 2005;54(5):226-230.
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    References

    1. Vávrová, H.: Remedia, 2001; 11, 47-53. Go to original source...
    2. Chalupová, Z., Masteiková, R., Savickas, A.: Čes. slov. Farm., 2005; 54, 55-59.
    3. Škarbalová, M.: Sborník 28. konference Syntéza a analýza léčiv, 1999, s. 94.
    4. Škarbalová, M., Klasovitá, J.: Zborník abstraktov 29. technologických dni, 1999, s. 33.
    5. Klasovitá, J., Škarbalová, M.: Zborník abstraktov 29. technologických dni, 1999, s. 34.
    6. Škarbalová, M., Vitková, Z., Klasovitá, J., Rak, J.: Zborník 29. konferencie Syntéza a analýza léčiv, 2000, s. 94.
    7. Škarbalová, M., Vitková, Z., Klasovitá, J., Rak, J.: Zborník 29. konferencie Syntéza a analýza léčiv, 2000, s. 95.
    8. Vitková, Z., Šubová, M., Zbudilová, J.: Sborník 32. konference Syntéza a analýza léčiv, 2003, s. 97.
    9. Cirbusová, Z., Vitková, Z., Šubová, M., Čižmárik, J.: Zborník abstraktov 31. technologických dni, 2003, s. 59.
    10. Vitková, Z., Gardavská, K., Čižmárik, J., Rak, J.: Acta Pol. Pharm. - Drug Res., 2000; 57, 381-384.
    11. Gardavská, K., Vitková, Z., Čižmárik, J.: Pharmazie, 2003; 58, 156-157.
    12. Vitková, Z., Šubová, M., Zbudilová, J. et al.: Farm. Obzor, 2003; 72, 197-200. Go to original source...
    13. Capková, Z., Vitková, Z., Uhrovská, S.: Farm. Obzor, 2004; 73, 235.
    14. Capková, Z., Vitková, Z., Bacskaiová, L.: Farm. Obzor, 2004; 73, 294. Go to original source...
    15. Jones, D. S., Brown, A. F., Woolfson, A. D.: J. Pharm. Sci., 2001; 90, 1978-1990. Go to original source... Go to PubMed...
    16. Desrieres, J., Hirrien, M., Rossmurphy, S. B.: Polymer, 2000; 41, 2451-2461. Go to original source...
    17. Chalabala, M. et al.: Technologie léků Galenika, 2. vyd. Praha, Galén, 2001, s. 143, 147, 151.
    18. Vitková, Z., Škarbalová, M., Klasovitá, J., Rak, J.: Čes. slov. Farm., 2002; 51, 37-40. Go to original source...
    19. Cirbusová, E., Šubová, M., Sušinková, J., Vitková, Z.: Farm. Obzor, 2004; 73, 295.
    20. Masteiková, R., Chalupová, Z., Šklubová, Z.: Medicina, 2003; 39, 19-24.
    21. Škarbalová, M.: Sborník 28. konference Syntéza a analýza léčiv, 1999, s. 94.
    22. Capková, Z., Vitková, Z., Vysokaiová, V.: Čes. slov. Farm, 2005; 54, 109-113.
    23. Macek, J., Ptacek, P., Klima, J.: J. Chromatography B, 1999; 736, 231-235. Go to original source... Go to PubMed...
    24. Makhija, S. N., Vavia, P. R.: J. Pharm. Biomed. Anal., 2001; 25, 663-667. Go to original source... Go to PubMed...
    25. Melwanki, M. B., Seetharamappa, J., Gowda, B. G., Sajjan, A. G.: Chemia Analityczna, 2001; 46, 883-887.
    26. Zathurecký, L., Chalabala, M., Janků, I., Modr, Z.: Biofarmácia a farmakokinetika, 1. vyd. Martin, Osveta, 1989, s. 349.
    27. Capková, Z., Vitková, Z., Uhrovská, S.: Farm. Obzor, 2004; 73, 235.
    28. Capková, Z., Vitková, Z., Gočaltovská, Z.: Farm. Obzor, 2004; 73, 295. Go to original source...

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