JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2005, 54(4):187-191

Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Loratadin-Containing Hydrogels

Z. Capková, Z. Vitková, V. Vysokaiová
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie

The paper examines the formulation of the antihistamine loratadin into hydrogels, the polymers under evaluation being Carbopol® 980 and Vivastar® P 5000. As other pharmaceutical auxiliary substances from the group of humectants are an indispensable component of hydrogels, the paper evaluates their influence (glycerol - GL, propylene glycol - PG, and sorbitol - SO) on the structural viscosity and pH of hydrogels as well as pharmaceutical availability of loratadin. On the basis of the results of the study it can be concluded that from the viewpoint of dermal administration of loratadin the hydrogels of the following composition are optimal: 0.5% Carbopol® 980 + 5% SO and 1.5 % Vivastar® P 5000 + 5 % PG.

Keywords: hydrogels; Carbopol® 980; Vivastar®P 5000; loratadin; humectants

Received: February 24, 2005; Accepted: March 31, 2005; Published: April 1, 2005  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Capková Z, Vitková Z, Vysokaiová V. Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Loratadin-Containing Hydrogels. Čes. slov. farm. 2005;54(4):187-191.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Urbánek, R.: Remedia, 1993; 3, s. 216-221.
    2. Gazdík, F, Janek, M.: Slov. Rev., 2000; 10, 68-70
    3. Firemná literatúra: Cleveland, Ohio, Carbopol Pharma, Noveon, Inc., 2002.
    4. Kim, J. Y., Song, J. Y., Lee, E. J., Park, S. K.: Coll. Polymer Sci., 2003; 281, 614-623. Go to original source...
    5. Kristmundsdottir, T., Sigurdsson, P., Thormar, H.: Drug Devel. Ind. Pharm., 2003; 29, 121-129. Go to original source... Go to PubMed...
    6. Gungor, S., Bergisadi, N.: Pharmazie, 2004; 59, 39-41. Go to original source...
    7. Shahiwala, A., Misra, A.: J. Pharm. Pharmac. Sci., 2002; 5, 220-225.
    8. Firemná literatúra: Product Data Sheet Carboxy Methyl Starch (Sodium Starch Glycolate) based on Potato Starch, Ellwangen - Holzmühle, Nemecko, firma J. Rettenmaier & SöhneGMBH+CO, 1997.
    9. Khalil, M., Aly, A. A.: Starch-starke, 2002; 54, 132-139. Go to original source...
    10. Srokova, I., Ebringerova, A., Heinze, T.: Tensides Surfactants Detergents, 2001; 38, 277-280.
    11. Seidel, C., Kulicke, W. M., Hess, C. et al.: Starchstarke, 2001; 53, 305-310.
    12. Vitková, Z., Cirbusová, E., Škarbalová, M. et al.: Farm. Obzor, 2002; 71, 252-254.
    13. Vitková, Z., Škarbalová, M., Cirbusová, E. et al.: Čes. slov. Farm., 2003; 52, 93-96. Go to original source...
    14. Vitková, Z., Šubová, M., Cirbusová, E. et al.: Farm. Obzor, 2003; 72, 59-63. Go to original source...
    15. Vitková, Z., Gardavská, K., Čižmárik, J., Rak, J.: Acta Pol. Pharm. - Drug Res., 2000; 57, 381-384.
    16. Güngör, S., Bergisadi, N.: Pharmazie, 2000; 58, 155-157.
    17. Vitková, Z., Šubová, M., Cirbusová, E., Čižmárik, J.: Zborník abstraktov, 31. technologické dni, Súčastný stav a trendy vo výskume, vývoji a výrobe liekových foriem. Piešťany, 2003, s. 47.
    18. Cirbusová, E., Vitková, Z., Šubová, M. et al.: Zborník abstraktov, 31. technologické dni, Súčastný stav a trendy vo výskume, vývoji a výrobe liekových foriem. Piešťany, 2003, s. 58.
    19. Cirbusová, E., Vitková, Z., Šubová, M., Čižmárik, J.: Zborník abstraktov, 31. technologické dni, Súčastný stav a trendy vo výskume, vývoji a výrobe liekových foriem. Piešťany, 2003, s. 59. Go to original source...
    20. Capková, Z., Vitková, Z., Vysokaiová, V.: Čes. slov. Farm, 2005; 54, 109-113.
    21. Zathurecký, L., Chalabala, M., Janků, I., Modr, Z.: Biofarmácia a farmakokinetika, 1. vyd. Martin, Osveta, 1989, s. 349.
    22. Capková, Z., Vitková, Z., Vysokaiová, V.: Farm. Obzor, 2004; 73, 294. Go to original source...

    Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.