Čes. slov. farm. 2004, 53(6):304-309
Adsorption of Substances on Active Charcoal Part 1: Basic Esters of Phenylcarbamic Acid with Local Anaesthetic Effect
- Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Active charcoal is one of important adsorbents capable of binding on their surface other substancesin a relatively large amount. This property is often used in pharmacy as well as in the studies of thestructure - biological activity relationships, where active charcoal serves as a model substance forthe study of hyrophobic interactions. The present paper investigates the adsorptivity of eightpotential local anaesthetics from the group of 1-methyl-2-piperidinoethylesters of 2-, 3- and 4-alkoxyphenylcarbamicacids to adjusted active charcoal, which complies with the requirements of SlovakPharmacopoeia 1. Adsorptivity of substances is evaluated according to Freundlich model andaccording to theamount of the bound substance β in per cents in dependence on time.The dependenceof adsorptivity of substances β on local anaesthetic activity in topical local anaesthesia, whichincreases with increasing lipophilicity, is evaluated.
Keywords: adsorption; active charcoal; esters of phenylcarbamic acid; local anaestheticagents
Published: June 1, 2004 Show citation