Čes. slov. farm. 2004, 53(5):256-260

Analytical Evaluation of 1-(Dipropalamino-3-piperidine-propane-1-yl)-3-pentyloxyphenylcarbamate(CK-3635)

I. Malík¹, E. Sedlárová¹, J. Csöllei²

¹ Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

² Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno

The paper presents the results of analytical and pharmacological evaluation and study of somephysicochemical properties of a potential drug marked as CK-3635 with high local anaestheticactivity. The structure of the substance has been confirmed by IR and UV spectroscopy. The meltingpoint, solubility, partition coefficient, capacity factor, surface activity, and dissociation constant weredetermined. The chromatographic behaviour of the drug on a thin layer was also investigated. Forthe content determination, spectrophotometry in the ultraviolet region of the spectrum at thewavelenght of the second absorption maximum of the substance, the titration in the two-phasesambient, and high-performance liquid chromatography were used.

Keywords: CK-3635; analytical evaluation; physicochemical properties; content determination

Published: May 1, 2004  Show citation