A Novel Group of Potential Antituberculotic Agents: Antimycobacterial N-Benzylsalicylamides
- 1 Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
- 2 Oddělení pro diagnostiku mykobakterií - Krajská hygienická stanice, Ostrava
Linking up with a previous study of antimycobacterial compounds, several groups of N-benzylsalicylamideswere prepared and their antimycobacterial activities against the strains Mycobacteriumtuberculosis,Mycobacterium kansasii, and Mycobacterium aviumwere evaluated.The obtained datawere analyzed by Free-Wilson method in comparison with their isosteric analogues of 3-hydroxypicolinicand 2-sulfanylbenzoic acids described in the previous communication.
Keywords: N-benzylsalicylamides; mycobacterium; tuberculostatics; QSAR
Published: June 1, 2003 Show citation