Čes. slov. farm. 2003, 52(2):93-96
A Study of the Rheological Properties of VIVASTAR® P 5000 Hydrogels
- Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Within the framework of pre-formulation studies, the paper evaluates the rheological properties ofhydrogels whose gel-forming substance is a polymer supplied by the firm J. Rettenmaier &SöhneGMBH+CO. It is VIVASTAR® P 5000, a modified derivate of carboxymethyl starch. The evaluationof rheological properties included hydrogels with 1.5, 2.0 and 2.5 w % of VIVASTAR® P 5000.The highest viscosity was shown by the hydrogel with 2.0% concentration of the polymer. The systemwithout and with the model drug with a local anaesthetic effect was thixotropic. From the viewpointof topical administration, VIVASTAR® P 5000 in 2.0% is optimal for hydrogel formulation.
Keywords: VIVASTAR® P 5000; hydrogels; model drug XXII B; rheological properties
Published: February 1, 2003 Show citation