Čes. slov. farm. 2003, 52(1):29-32
Kinetics of Release of Scopolamine Bromide from Hydrogel by a Filtering Membrane
- Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
The hydrated filtration membrane renders possible uniform hydration of hydroxypropylmethylcellulosehydrogel with subsequent uniform release of dissolved scopolamine bromide. Exponentialdependence of the diffusion coefficient on the graded medium dimension of the pores of the testingmembrane makes possible the estimation of the reactive fractal dimension DR by means of themodified exponent (3 - DR).With increasing concentration of scopolamine bromide in xerogel (14.7to 77.8 mg/cm3), DR decreases within a range of 2.814 to 2.704. A comparison with the structure ofa suitable fractal (Menger sponge) leads to a conclusion about suitability of the use of membranesfor the testing of concentrations of scopolamine bromide in xerogel, if DR > 2.727.
Keywords: scopolaminium bromide; hydrogel; filtering membrane; diffusion coefficient; reactive fractal dimension
Published: January 1, 2003 Show citation