JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(6):305-309

Preparation and Physico-Chemical Properties of Alkyl Esters of [(2-Hydroxy 3-diphenyl-methylpiperazinyl)propoxy] Carbanilic Acids

R. Opatřilová, P. Mokrý, J. Csöllei, M. Blešová
Ústav chemických léčiv, Farmaceutická fakulta VFU, Brno

The paper is devoted to the synthesis and study of some physico-chemical properties of a group ofsubstances - potential antagonists of beta-adrenergic receptors. The substances are derivatives ofaryloxyaminopropanol, where the basic part consists of diphenylmethylpiperazine and the aromaticpart is modified with alkyl esters (methyl to butyl) of carbamic acid in positions 2-, 3-, 4-. Therepresentation of the elements was confirmed by elemental analysis. The substances were characterizedby melting point, IR and UV spectra. Their solubility and surface acitivity were determined.The purity of prepared substances was examined by means of TLC.

Keywords: preparation; aryloxyaminopropanol; surface tension; TLC

Published: June 1, 2002  Show citation

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Opatřilová R, Mokrý P, Csöllei J, Blešová M. Preparation and Physico-Chemical Properties of Alkyl Esters of [(2-Hydroxy 3-diphenyl-methylpiperazinyl)propoxy] Carbanilic Acids. Čes. slov. farm. 2002;51(6):305-309.
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