Čes. slov. farm. 2002, 51(4):205-207

Anti-Inflammatory Activities of (o-Cresotato)copper(II) and -zinc(II)Aquacomplexes

J. Sokolík, I. Tumová, M. Bláhová, M. Bernáthová, P. Švec

Katedra chemickej teórie liečiv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava

Using rat paw dextran-induced and carrageenan-induced edemas,the antiedematous activites ofmonohydrate of the diaquatetrakis(o -cresotato)dicopper(II)complex (Cu o C)and the diaquabis(o-cresotato)zinc(II)complex (Zn o C)were assayed plethysmometrically.Dihydrate of the diaquabis(salicylato)copper(II)complex (CuS)and the diaquabis(salicylato)zinc(II)complex (ZnS)were used asthe standards of comparison.All compounds were administered i.p.in a single dose of 50 µmol/kgbody weight (calculated for the RCOO-fragment)30 min before injecting the irritants.The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction)were found:Cu o C 36/54 %-Zn o C 59/65 %-CuS 71/52 %-ZnS 63/10 %.The relationships between thecoordination-chemical properties and the biological effects of the corresponding complexes arediscussed.

Keywords: copper(II)and zinc(II)o -cresotates; rat paw dextran-induced and carrageenan-induced edemas; anti-inflammatory activity

Published: April 1, 2002  Show citation