JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(3):150-153

Studies of Local AnaestheticsCLIX. HPLC Separation of 1-Methyl-2-piperidinoethylesters of Alkoxyphenylcarbamic Acid

M. Renčová, J. Čižmárik, J. Lehotay, K. Hroboňová
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Katedra analytickej chémie Chemicko-technologickej fakulty STU, Bratislava

The paper employed R- and y-cyclodextrins as chiral stationary phases in HPLC, the mobile phases being polar organic solvents. Enantiomers of alkoxysubstituted esters of phenylcarbamic acids (local anaesthetics) were separated and various effects on the process of separation were examined. Primarily the effects of the composition and concentration of organic solvents and the effect of the presence of ionic modifiers in the mobile phase were investigated. The conditions of separation of the enantiomers of phenylcarbamic acid derivatives were found. Interactions influencing separation of enantiomers are also discussed.

Keywords: separation of enantiomers; chiral staionary phases; HPLC; R-cyclodextrin; y-cyclodextrin; alkoxysubstituted esters of phenylcarbamic acid

Published: March 1, 2002  Show citation

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Renčová M, Čižmárik J, Lehotay J, Hroboňová K. Studies of Local AnaestheticsCLIX. HPLC Separation of 1-Methyl-2-piperidinoethylesters of Alkoxyphenylcarbamic Acid. Čes. slov. farm. 2002;51(3):150-153.
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